PROPANORM® (Propafenone)

What is Propanorm (Propafenone)?

Propanorm® is an antiarrhythmic medication used to treat certain types of irregular heartbeats, specifically supraventricular and ventricular arrhythmias.

This medication works by stabilizing the heart’s electrical activity, helping to restore a regular heartbeat.

Propanorm® tablets come in two strengths: 150 mg and 300 mg, and they are coated with a film to make them easier to swallow.

It's important to follow your healthcare provider's instructions regarding dosage and treatment duration for the best results.

What conditions does Propanorm treat?

Propanorm® is used to manage and treat the following heart rhythm disorders:

• Symptomatic supraventricular arrhythmias, such as atrioventricular nodal reentrant tachycardia and supraventricular tachycardia associated with Wolff-Parkinson-White syndrome.
• Paroxysmal atrial fibrillation (occasional episodes of rapid heartbeat).
• Severe symptomatic ventricular tachyarrhythmias when deemed life-threatening by a doctor.

How should you take Propanorm?

Always take Propanorm® exactly as prescribed by your doctor. The typical starting dose for an adult weighing about 70 kg is between 450 mg and 600 mg per day, divided into two or three doses.

Some patients may need up to 900 mg per day.

Doses should be carefully adjusted by a healthcare provider, especially in elderly patients or those with reduced heart function.

Swallow the tablets whole with water after meals, without crushing or chewing them.

What precautions should be taken before starting Propanorm?

Before taking Propanorm®, inform your healthcare provider about any medical conditions you may have. Propanorm® is not suitable for everyone, and there are certain contraindications, such as:

• Hypersensitivity to propafenone or any of its ingredients.
• Brugada syndrome or significant structural heart issues (such as recent heart attack or heart failure).
• Severe lung disease or electrolyte imbalances.
• Myasthenia gravis (a neuromuscular disorder). Additionally, avoid taking grapefruit juice while on Propanorm®, as it can increase the medication’s concentration in your bloodstream.

What are the potential side effects of Propanorm?

Like any medication, Propanorm® may cause side effects, although not everyone experiences them. The most common side effects include:

• Dizziness
• Palpitations (feeling your heartbeat)
• Nausea or gastrointestinal discomfort
• Visual disturbances

In rare cases, more severe side effects can occur, such as serious heart rhythm disturbances, worsening of existing heart failure, or allergic reactions.

If you experience symptoms like fainting, shortness of breath, or chest pain, seek immediate medical attention.

Can Propanorm interact with other medications?

Yes, Propanorm® can interact with various other medications, so it’s important to inform your doctor about all the medicines you are currently taking. Notable interactions include:

• Increased propafenone levels when taken with certain antibiotics, antifungals, or grapefruit juice.
• Increased risk of side effects when combined with lidocaine, amiodarone (another antiarrhythmic), or certain antidepressants.
• Altered effectiveness when taken with certain blood pressure medications or anticoagulants like warfarin.

Is Propanorm safe for pregnant or breastfeeding women?

The safety of Propanorm® during pregnancy or breastfeeding is not well-established.

Since the drug can cross the placenta and may be excreted in breast milk, it should only be used if the potential benefits outweigh the risks

If you are pregnant, plan to become pregnant, or are breastfeeding, consult your doctor before using this medication.

How should Propanorm be stored?

Store Propanorm® tablets at a temperature below 25°C (77°F) in their original packaging.

Keep them out of reach of children and do not use the medication beyond its expiration date.