Polyoxidonium 10s 12 mg suppositories

The instruction for medical use of Polioksidoniy® medicine the Trade name of Polioksidoniy® the International unlicensed name Azoksimera bromide the Dosage form Suppositories vaginal and rectal, 6 mg and 12 mg Structure One suppository contains active agent - an azoxymeasure bromide of 6 mg and 12 mg excipients: Mannitolum, povidone, cocoa butter the Description Suppositories of a torpedo-shaped form, light yellow color with a slight specific smell of cocoa butter. Suppositories have to be uniform. On a cut the existence of an air core or funneled deepening is allowed. Pharmacotherapeutic group Anti-neoplastic and immunomodulatory drugs. Immunostimulators. The ATX L03 code the Pharmacological Azoksimer's Pharmacokinetics properties bromide in suppositories at rectal administration has high bioavailability (not less than 70%), reaching the maximum concentration in blood in 1 hour after introduction. Semi-distribution period about 0.5 hours, semi-elimination period 36.2 hours. In an organism it is hydrolyzed to oligomers which are removed mainly by kidneys. The cumulative effect is absent. Azoksimer's pharmacodynamics bromide possesses complex action: immunomodulatory, detoksitsiruyushchy, antioxidant, moderate anti-inflammatory. A basis of the mechanism of immunomodulatory action of Azoksimer of bromide is direct impact on englobing cells and natural killers and also stimulation of antibodyformation and synthesis of interferon alpha and interferon - gamma. Detoksikatsionny and antioxidant Azoksimera properties of bromide in many respects are defined by structure and the high-molecular nature of drug. Azoksimera bromide increases resistance of an organism concerning local and generalized infections of a bacterial, fungal and virus etiology. Restores immunity in the secondary immunodeficiency caused by various infections, injuries, complications after surgeries, burns, autoimmune diseases, malignant new growths, use of chemotherapeutic means, tsitostatik, steroid hormones. Azoksimera bromide blocks soluble toxic substances and microparticles, has ability to bring toxins, salts of heavy metals out of an organism, inhibits peroxide oxidation of lipids both due to interception of free radicals, and by means of elimination catalystically of active ions of Fe2+. Azoksimera bromide reduces inflammatory reaction by means of normalization of synthesis about - and anti-inflammatory cytokines. Azoksimera bromide is well had, has no mitogenetic, polyclonal activity, antigenic properties, does not render allergenic, mutagen, embriotoksichesky, teratogenic and cancerogenic action. Indications it Is applied at adults and children 6 years for treatment and prevention of infectious and inflammatory diseases (virus, bacterial and fungal etiology), in a stage of aggravation and remission are more senior. For treatment (in complex therapy): - sharp and exacerbations of chronic recurrent infectious and inflammatory diseases of various localization, a bacterial, virus and fungal etiology, - inflammatory diseases of an urogenital path (urethritis, cystitis, pyelonephritis, prostatitis, a salpingo-oophoritis, an endomyometritis, a colpitis, a cervicitis, a tservikoz, bacterial vaginoses), - various forms of a pulmonary tuberculosis, - the allergic diseases (including a pollinosis, bronchial asthma, atopic dermatitis) complicated by a recurrent bacterial, fungal and viral infection - the pseudorheumatism complicated by a recurrent bacterial, fungal and viral infection against the background of long reception of immunodepressants, - for activation of regenerator processes (fractures, burns, trophic ulcers), - in complex therapy of oncological diseases when carrying out khimio- and radiation therapy, for decrease nefro- and hepatotoxic action of medicines. For prevention (monotherapy): - a recurrent herpes infection of an urogenital path - aggravations of the chronic centers of infections - flu and other acute respiratory infections during the preepidemic and epidemic period at immunokomprometirovanny persons - the secondary immunodeficiences arising owing to aging or influence of adverse factors. A route of administration and doses Use drug only according to those indications, that route of administration and in those doses which are specified in the instruction. If after treatment of improvement does not come or symptoms are aggravated, or there are new symptoms, it is necessary to consult with the doctor. Rektalno and vaginalno 1 time a day daily, every other day or 2 times a week. If necessary carrying out repeated courses of therapy in 3-4 months is possible. At repeated prescribing of drug its efficiency does not decrease. The recommended schemes of use of drug For treatment by the adult: – rektalno on 1 suppository of 1 times a day after purgation, – vaginalno in gynecologic diseases on 1 suppository of 1 times a day (for the night) it is entered into a vagina in a prone position. - in chronic infectious and inflammatory diseases in an aggravation stage suppositories of 12 mg of 1 times a day daily within 3 days, then every other day. A course of treatment of 10 suppositories, - at acute infectious processes and for activation of regenerator processes (fractures, burns, trophic ulcers) suppositories of 12 mg of 1 times a day daily. A course of treatment of 10 suppositories, - in gynecologic diseases suppositories of 12 mg of 1 times a day daily within 3 days, then every other day. A course of treatment of 10 suppositories, - at exacerbation of urological diseases (urethritis, pyelonephritis, cystitis, prostatitis) suppositories of 12 mg of 1 times a day daily. A course of treatment of 10 suppositories, - at a pulmonary form of tuberculosis suppositories of 12 mg of 1 times a day daily within 3 days, then every other day. Course of treatment of 20 suppositories. Further use of maintenance therapy by suppositories of 6 mg 2 times a week, a course up to 2-3 months is possible, - in complex therapy of oncological diseases when carrying out khimio- and radiation therapy suppositories of 12 mg daily in 2-3 days prior to the beginning of a course khimio- or radiation therapy. Further on 12 mg 2 times a week, a course up to 20 suppositories, - in the allergic diseases complicated by an infectious syndrome suppositories of 12 mg of 1 times a day daily. A course of treatment of 10 suppositories, - in a pseudorheumatism suppositories of 12 mg every other day. Course of treatment of 10 suppositories. For prevention (monotherapy): - aggravations of the chronic centers of infections, recurrent herpes infection of an urogenital path suppositories of 12 mg every other day. A course of 10 suppositories, - flu and a SARS suppositories of 12 mg of 1 times a day. A course of 10 suppositories, - the secondary immunodeficiences arising owing to aging suppositories of 12 mg 2 times a week. A course 10 suppositories, 2-3 times a year. For treatment children and teenagers are from 6 to 18 years old: To children and teenagers from 6 to 18 years suppositories are entered only rektalno, on 1 suppository of 6 mg of 1 times a day after purgation. - in chronic infectious and inflammatory diseases in an aggravation stage suppositories of 6 mg of 1 times a day daily within 3 days, then every other day. A course of treatment of 10 suppositories, - at acute infectious processes and for activation of regenerator processes (fractures, burns, trophic ulcers) suppositories of 6 mg of 1 times a day daily. A course of treatment of 10 suppositories, - at exacerbation of urological diseases (urethritis, pyelonephritis, cystitis, prostatitis) suppositories of 6 mg of 1 times a day daily. A course of treatment of 10 suppositories, - at a pulmonary form of tuberculosis suppositories of 6 mg of 1 times a day daily within 3 days, then every other day. Course of treatment of 20 suppositories. Further use of maintenance therapy suppositories of 6 mg 2 times a week, a course up to 2-3 months is possible, - in complex therapy of oncological diseases when carrying out khimio- and radiation therapy suppositories of 6 mg daily in 2-3 days prior to the beginning of a course khimio- or radiation therapy. Further on 6 mg 2 times a week, a course up to 20 suppositories, - in the allergic diseases complicated by an infectious syndrome suppositories of 6 mg of 1 times a day daily. A course of treatment of 10 suppositories, - in a pseudorheumatism suppositories of 6 mg every other day. Course of treatment of 10 suppositories. For prevention (monotherapy): - aggravations of the chronic centers of infections, recurrent herpes infection of an urogenital path suppositories of 6 mg every other day. A course of treatment of 10 suppositories, - flu and a SARS suppositories of 6 mg of 1 times a day. Course of treatment of 10 suppositories. For patients, it is long receiving immunosuppressive therapy, oncological, undergone radiation, having the acquired defect of the immune system of HIV, maintenance therapy by Polioksidony is shown long from 2-3 months to 1 year (the adult on 12 mg, children 6 years on 6 mg 1-2 times a week are more senior). Side effects Very seldom (& lt, 1/10,000) – perhaps allergic reactions, local reactions in the form of reddening, hypostasis, an itching of a perianal zone, a vaginal itching in connection with individual sensitivity to drug components. At emergence of side reactions and also at emergence of the side reaction which is not mentioned in the instruction of medical use it is necessary to see the attending physician. Contraindications - individual hypersensitivity to drug components, - pregnancy and the period of a lactation (clinical experience of use is absent), - use for children: in a dose of 12 mg do not apply at children, in a dose of 6 mg do not apply at children up to 6 years, - an acute renal failure. Report medicinal interactions Before an initiation of treatment to the doctor about all medicines taken by you. Azoksimera bromide does not inhibit isoenzymes of CYP1A2, CYP2S9, CYP2S19, CYP2D6, R-450 cytochrome and is combined with many medicines, including is compatible to antibiotics, antiviral, antifungal and antihistaminic drugs, glucocorticosteroids and cytostatics. Special instructions It is medicine it is released without prescription. For achievement of optimum results it should be used, strictly implementing all recommendations stated in the instruction. Medicine by which you are treated is intended personally to you, and he should not be transferred to other persons as it can do them harm even in the presence of the same symptoms, as at you. If you had questions, see a doctor. At development of allergic reaction it is necessary to stop use of the drug Polioksidoniy® and to see a doctor. In need of the therapy termination by drug, cancellation can be carried out at once. In case of the admission of a single dose of drug it is necessary to accept it as soon as possible, but if there came time of reception of the following dose, not to increase a dose by reception. It is not necessary to exceed the specified doses and duration of a course of treatment without consultation with the attending physician. Do not use drug with visual signs of its unfitness (defect of packing, discoloration of suppositories). In a dose of 6 mg to children from 6 to 18 years suppositories are entered only rektalno. Pregnancy and a lactation use at pregnancy and during breastfeeding is contraindicated (clinical experience of use is absent). Before drug Polioksidoniy® use if you are pregnant, or you assume that you could be a pregnant woman, or you plan pregnancy, it is necessary to consult with the doctor. During breastfeeding before use of the drug Polioksidoniy® it is necessary to consult with the doctor. Features of influence of drug on ability to run the vehicle or potentially dangerous mechanisms. Use of the drug Polioksidoniy® does not affect ability of control of vehicles, service of mechanisms and other types of the works demanding the increased concentration of attention and speed of psychomotor reactions. Overdose Cases of overdose are not registered. The form of release and packing On 5 suppositories place in blister strip packaging from a film polyvinylchloride. Two blister strip packagings together with the instruction for medical use in the state and Russian languages put in a pack from cardboard. To Store storage conditions at a temperature from 2 °C to 15 °C. To store out of children's reach! Period of storage 2 years. Not to apply after an expiration date. Prescription status Without prescription. LLC NPO Petrovax Pharm producer, Russian Federation Legal address: 142143, Moscow region, city of Podolsk, village Cover, Sosnovaya St., 1, ph./fax: +7 (495) 926-21-07, e-mail: info@petrovax.ru. Made: 115598, Moscow, Zagoryevskaya St., 10, building 4, ph./fax: +7 (495) 329-17-18. Packed: 142143, Moscow region, city of Podolsk, village Cover, Sosnovaya St., 1, ph./fax: +7 (495) 926-21-07. The holder of the registration certificate of LLC NPO Petrovax Pharm, the Russian Federation the Name, the address and a contact information (phone, the fax, e-mail) of the organization in the territory of the Republic of Kazakhstan, the accepting claim (offer) on quality of medicines from consumers and responsible for post-registration observation of safety of medicine: Address: LLC NPO Petrovax Pharm Russian Federation, 142143, Moscow region, city of Podolsk, village Cover, Sosnovaya St., 1 Phone number: +7 (495) 926-21-07, +7 (495) 730-75-45 Fax: +7 (495) 926-21-07 E-mail address: adr@petrovax.ru the Authorized representative in the Republic of Kazakhstan the Address: KFK Medservice Plus LLP Republic of Kazakhstan, Almaty, Mametova St., 54 Phone number: +7 (727) 279 86 02 Fax: +7 (727) 279 98 21
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