Octolipen® (Thiotic Acid) 30mg/ml (10 vials)

Structure

One ampoule contains:
active substance: thioctic acid (α-lipoic acid) in terms of 100% substance - 300 mg
excipients: ethylenediamine, disodium edetate, water for injection

Indication for use

- diabetic polyneuropathy
- alcoholic polyneuropathy

Uses

To prepare an infusion solution, 1-2 ampoules (300 - 600 mg) of the drug are diluted in 50-250 ml of 0.9% sodium chloride solution.

The finished solution is injected intravenously. Apply at 300-600 mg once a day for 2-4 weeks. In the future, they switch to oral therapy.

The drug is photosensitive, so the ampoules should be taken out of the package only immediately before use. It is advisable to protect the bottle with the solution from light during the infusion (you can use light-protective bags, aluminum foil).

The prepared solution must be stored in a dark place and used within a maximum of 6 hours after preparation.

Side effects

Often
- with a rapid intravenous injection, a feeling of rush of blood to the head and difficulty in breathing may develop, which pass on their own.
Infrequently
- nausea, vomiting, change or violation of taste.
Very rarely
- reactions at the injection site allergic reactions such as rashes, itching, eczema, and systemic hypersensitivity reactions can develop to anaphylactic shock
- convulsions
- the development of symptoms of hypoglycemia (due to improved absorption of glucose)
- diplopia
- punctate hemorrhages in the mucous membranes, skin
- thrombocytopathy, hemorrhagic rash (purpura), thrombophlebitis
- increased intracranial pressure (the appearance of a feeling of heaviness in the head)

Contraindications

- hypersensitivity to drug components
- pregnancy and breastfeeding period
- children under 18 years of age (efficacy and safety of use have not been established)

Drug interactions

Thioctic acid (in the form of a solution for infusion) reduces the effect of cisplatin.

With simultaneous use with insulin and / or oral hypoglycemic agents, an increase in the hypoglycemic effect is observed.

Thioctic acid forms difficultly soluble complex compounds with sugar molecules. The prepared solution is incompatible with glucose solution, levulose, Ringer's solution, as well as with compounds (including their solutions) that react with disulfide and SH-groups.

The drug should not be administered concurrently with iron, magnesium, potassium preparations, the time interval between taking these drugs should be at least 5 hours.

Special instructions

In patients with diabetes mellitus, especially at the beginning of treatment, frequent monitoring of blood glucose concentration is necessary. In some cases, a decrease in the dose of hypoglycemic agents is required.

During treatment, it is necessary to strictly refrain from drinking alcohol, since the therapeutic effect of thioctic acid is weakened by the influence of alcohol.

Ethanol reduces the therapeutic efficacy of thioctic acid.

Features of the impact on the ability to drive a vehicle and potentially dangerous mechanisms

Care should be taken when driving due to possible symptoms of hypoglycemia (dizziness, blurred vision)

Overdose

Symptoms: headache, nausea, vomiting.
Treatment: symptomatic. There is no specific antidote.

Storage conditions

Store in a dark place at a temperature not exceeding 25 ° C.
Keep out of the reach of children!

Shelf life - 2 years
Do not use the drug after the expiration date!