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Nosid 20s chewing tablets

  • $7.90
Sku: e86059ccc447
Brand: AGIO (India)
NOSID

the Trade name
Nosid

Mezhdunarodnoye the unlicensed name
Is not present

the Dosage form
chewable tablets

Structure
One tablet contains
active agents: aluminum hydroxide dry gel of 400.0 mg
magnesium hydroxide of 400.0 mg,
excipients: Mannitolum, povidone (PVP K-30), liquid sorbitol (70% uncrystallized), sodium saccharinate, sucrose, 2 propyl alcohol, the sucralose, water purified, silicon dioxide colloidal anhydrous, flavoring additive mint / flavoring additive mint encapsulated (KAL-5541), magnesium stearate.

The description
of the Tablet of round shape, with a flat surface, white color, with impregnations with mown by edges with pleasant taste.

Pharmacotherapeutic group
Drugs for treatment of the diseases connected with disturbance of acidity. Combination of drugs of aluminum, calcium and magnesium.
The ATX A02AD01 code

the Pharmacological

Pharmacokinetics Hydroxides properties of magnesium and aluminum – locally acting, non-systemic antiacid means which absorption is insignificant under normal conditions uses. Nosid chewable tablets are badly soaked up from digestive tract. In the course of neutralization the ions of magnesium and aluminum are released in insignificant degree. Generally they turn into almost insoluble phosphates during passing through intestines and are removed in such view with excrements. A number of ions of magnesium and aluminum are soaked up that leads to temporary increase in concentration of aluminum in blood plasma and to increase in its renal excretion. Aluminum levels in blood plasma remain lower than the range of toxicity and return to normal values within 3-5 days after the treatment termination. The small fraction of magnesium is soaked up. Concentration of magnesium in blood plasma, as a rule, remain constants owing to removal by kidneys. In cases of a renal failure and long reception of high doses can take place a gipermagniyemiya and even intoxication magnesium, besides, aluminum deposits, especially in a nervous and bone tissue can gradually be formed.
The pharmacodynamics
Nosid protects a mucous membrane of a gullet, a stomach and a duodenum, neutralizing hydrochloric acid of gastric juice. Nosid has the adsorbing and enveloping effect, reducing impact of disturbing factors on a mucous membrane.
The combination of aluminum hydroxide and magnesium hydroxide uses various reactions of active agents against acid. Magnesium hydroxide leads to fast and short-term increase intragastric rn within not physiological values (rn 7-8) while aluminum hydroxide is too weak to use only it. The combination of both hydroxides leads to long binding of protons which total amount is equal to total number of ions of aluminum and magnesium. Hydroxides of magnesium and aluminum affect sokratitelny ability of intestines in various ways. Magnesium hydroxide possesses laxative action whereas aluminum hydroxide leads to a constipation.
Nosid is passable for X-rays. The general antiacid ability of one dose (titration at rn 1) 14.71 mmol of H+ (by the Vatier method).

Indications
- heartburn and an acid eructation at adults and children from 15-summer age.

A route of administration and doses
Children from 15-year age and adults:
On 1-2 tablets to rassasyvat or chew in heartburn and an acid eructation.
The maximum quantity of doses in day: 6 doses (1 dose may contain 1-2 tablets, therefore, 6 doses x 1-2 tablets = 6 - 12 tablets a day).
It is not necessary to take more than 12 pill a day.

Side effects
Seldom:
- constipations, change of consistence of a chair, nausea, vomiting, change of flavoring feelings
- allergic reactions
Other:
- compensatory hypersecretion of gastric juice at frequent reception of high doses
- a gipermagniyemiya and a hypercalcemia at patients with a renal failure at prolonged use of drug
- a hypophosphatemia after long use or after high doses of drug because of aluminum content in this drug.

Contraindications
- hypersensitivity to drug components
- the profound renal failures

the Medicinal interactions
of the Combination demanding observance of precautionary measures at use
decrease in gastrointestinal absorption of at the same time taken medicines Is noted. As a precautionary measure, it is desirable to observe an interval between reception of antacids and other medicines. As far as possible it is necessary to observe an interval more than 2 hours between intake of this drug and the following medicines: H2 - antihistamines, antitubercular drugs: Ethambutolum, an isoniazid (peroral), atenolol, metoprolol, propranolol, chloroquine, tsiklina, diflunizat, digoxin, diphosphonates, feksofenadin, iron (salts), ftorkhinolona, fluoric sodium, glucocorticoid drugs (it is described in connection with Prednisolonum and dexamethasone), indometacin, keyiksalat, ketokonazol, lanzoprazol, linkozamida, fenotiazinovy neuroleptics, Penicillaminum, phosphorus (additives), thyroxine.
Combinations which it is necessary to consider
salicylates (the strengthened removal of salicylates kidneys as a result of urine alkalization).

Special instructions
Patients have to see a doctor behind council in a case:
- weight reduction of a body
- difficulties when swallowing and persistent feeling of discomfort in a stomach
- disturbances of the digestion which appeared for the first time or changes in the available digestion disturbances
- a renal failure.
In view of the content of sorbitol and sucrose in this medicine, it is not recommended to patients with intolerance of fructose, a syndrome of malabsorption of glucose galactose or deficiency of invertase-isomaltase, patients with diabetes are recommended to take with caution.
Precautionary measures at use
in case of patients with a renal failure or being on chronic dialysis, it is necessary to consider aluminum content in drug (danger of development of encephalopathy).
If during treatment the symptoms remain more than 10 days or if deterioration follows, it is necessary to check an etiology of a disease and to reconsider treatment.
Use in pediatrics
the Published clinical data on experience of use of magnesium of a hydrochloride and aluminum of hydroxide up to 15 years are limited.
Pregnancy and the period of a lactation
to Use drug during pregnancy only in case of need. During treatment it is possible to continue feeding by a breast.
Influence on ability to drive the car and the equipment
does not influence

Overdose
Symptoms: administration of drug and in high doses can lead for a long time to a hypercalcemia which disappears after the termination of administration of drug.
Treatment: symptomatic therapy (at overdose, magnesium carries out rehydration, an artificial diuresis, in case of a renal failure the hemodialysis or peritoneal dialysis is necessary).

A form of release and packing
On 10 tablets in blister strip packaging from a film of polyvinylchloride and aluminum foil. On 2 planimetric packs together with the instruction for medical use in the state and Russian languages place in a cardboard box.


To Store storage conditions in the dry, protected from light place at a temperature not higher than 25 wasps. Not to freeze!
To store out of children's reach!



Not to use a period of storage of 5 years after the expiration date specified on packing.

Prescription status
Without prescription


Agio Pharmaceuticals Ltd Producer, India
T-82, M.I.D.S., Bhosari, Pune – 411,026, India
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