Nolicin® (Norfloxacin) 400 mg, 10 coated tablets

Nolicin - norfloksatsintabletka
ftorokhinolon
Sostav1 the tablet contains 400 mg of norfloxacin.
DeystvieNolitsin - peroral uroantiseptik a hinolonovy row, having bactericidal effect. Has the significant effect concerning the majority gram-negative (E. of coli, Klebsiella, Proteus, Providentia, Enterobacter, Morganella, Citrobacter, Serratia, Pseudomonas) and some gram-positive bacteria (staphylococcus), is less active concerning atsinetobakteriya and enterococci. Does not show activity concerning anaerobic bacteria and streptococci. After oral administration, Nolicin quickly, but short is soaked up. Food (especially milk, yogurt) slows down its absorption. 15% of drug contact proteins of serum. The maximum concentration in serum is noted in 60-90 minutes after oral administration. In urine reaches concentration by 200-300 times exceeding concentration in serum. Elimination half-life makes 2.5-4.5 hours. Also about 30% are allocated with urine mainly in not changed look (up to 8% of drug it is allocated in the form of metabolites) - with a stake.
Indications

Acute and persistent infections of urinary tract.
Chronic bacterial prostatitis.
Gonorrhea.
Dysentery.
Salmonellosis.
Prevention of infections of a digestive tract and prevention of diarrhea of travelers. Contraindications

Hypersensitivity to drugs of a hinolonovy row.
Pregnancy and feeding by a breast.
It is not recommended to appoint drug to children during a growth period. Predostorozhnostisledut measures to be careful when prescribing Nolicin the patient with dysfunctions of the central nervous system. During treatment the patient should avoid immediate effect of sunshine. In a renal failure the dose of drug needs to be selected individually. It is reported about separate cases of inflammation or even a rupture of sinews during treatment of a hinolonama. Though the causal relationship using drug in this case is incontestably not proved, the patient has to stop administration of drug at appearance of pains in sinews or at the first signs of inflammation of sinews. During treatment or directly after it it is necessary to avoid excess physical activities.
VzaimodeystvieNeobhodima care at the simultaneous use of norfloxacin with theophylline (since side effects of theophylline amplify) or cyclosporine and warfarin (the therapeutic effect of the last increases). Milk, yogurt, antacids, sukralfat and the drugs containing iron or zinc reduce norfloxacin absorption. Patients have to accept Nolicin for an hour to or in two hours after intake of milk or yogurt. Antacids, sukralfat, it is necessary to accept preparations of iron or zinc 2 hours later after intake of norfloxacin.
Pregnancy and feeding a grudyyubezopasnost of use of drug during pregnancy and feeding by a breast is not proved. Use of drug is allowed if the expected advantage for mother exceeds risk for the child (D).
Special ukazaniyevrach and the druggist have to warn the patient that it is not recommended to run vehicles and to work with mechanisms before clarification of individual reaction of an organism to drug. Norfloxacin can cause dizziness therefore reduces speed of reaction, especially if the patient at the same time takes alcoholic beverages.
DozirovkaNolitsin it is necessary to accept, washing down with water. The entire period of drug treatment needs to be supported a normal diuresis.
Treatment



the Indication
the Daily dosage

1 tablet = 400 mg
treatment duration

acute urinary tract infections
2 x 400 mg
7 up to 10 days *

persistent infections of uric ways
2 x 400 mg
up to 12 weeks

chronic bacterial prostatitis
2 x 400 mg
of 4-6 weeks

gonorrhea
2 x 400 mg
of 3-7 days

1 x 800-1200 mg


once bacterial infections of a GIT
2 x 400 mg
up to 5 days
* In an acute uncomplicated infection of a bladder at women treatment continues from 3 to 5 days
Nolitsin's Dose decreases if clearance of creatinine less than 0.33 ml/sec. (20 ml/min.) or concentration of creatinine in serum higher than 400 µмоль/л (4.5 mg / 100 ml). The dose decreases half or the interval between usual doses doubles. At the patients on a hemodialysis having a normal diuresis, the dose also decreases twice. The patient on chronic peritoneal dialysis with the kept diuresis appoint the same dose, as during the normal work of kidneys.
Prevention



the Indication
the Daily dose

1 tablet =
baking duration

sepsis at patients with a neutropenia
2 x 400 mg
to 8 weeks

recurrent urinary tract infections of 4-5 times a year and is more often than 400 mg)
200 mg in the evening
1 years or 2 years

diarrhea of travelers
1 x 400 mg
up to 21 days *
* One day before departure, all the time of a travel and two more days after return however no more than 21 day.
Collateral deystviyapr the recommended doses seldom appear allergic reactions (urticaria, an itching), disturbance of work of digestive tract (nausea, anorexia, diarrhea), a headache, dizziness. During treatment by norfloxacin increase in indicators of activity of transaminases, alkaline phosphatase, a lactate of dehydrogenase, concentration of urea and creatinine in serum, decrease in a hematocrit, an eosinophilia and a leukopenia can be observed. By-effects at use of ftorkhinolon are very rare. Their emergence is usually connected with existence of other factors therefore the tendinitis or a rupture of a suhozhiliyPeredozirovkaPra to overdose of drug can develop can digestion disturbance will appear. At acute overdose the gastric lavage is recommended. The organism of the patient has to be provided with enough liquid to avoid a crystalluria.
Upakovka20 tablets on 400 mg, 10 tablets on 400 mg.