Nobetazon 0.1% 30g of the cream for external use

$13.00

Sku: 2bf8d79345bb

Brand: Nobel AFF (Kazakhstan)

Ingredient: Betamethasone

Compound

1 g of cream contains

active substance - betamethasone valerate 1.22 mg (equivalent to betamethasone 1 mg)

excipients : cetomacrogol 1000, chlorcresol, sodium dihydrogen phosphate monohydrate, sodium hydroxide, phosphoric acid, white petrolatum, liquid paraffin, cetostearyl alcohol, purified water.

Pharmacological properties

Pharmacokinetics

Data on the pharmacokinetics of the drug Nobetasone are not available.

Pharmacodynamics

Nobetasone has anti-inflammatory, antipruritic and vasoconstrictive effects. Betamethasone inhibits the release of cytokines and inflammatory mediators, reduces the metabolism of arachidonic acid, initiates the formation of lipocortins with anti-edematous activity, and reduces vascular permeability.

Indications for use

- inflammatory manifestations in dermatoses sensitive to corticosteroid therapy

- atopic dermatitis (including childhood atopic dermatitis)

- nummular dermatitis (eczema nummular)

- allergic contact dermatitis

- seborrheic dermatitis

- neurodermatitis, solar dermatitis

- exfoliative dermatitis

- stasis dermatitis

- radiation dermatitis

- intertriginous dermatitis

- otitis externa

- psoriasis

- lichen planus

- discoid lupus erythematosus

- anogenital and senile itching

- insect bite reactions

Dosage and administration

Nobetasone is applied in a thin layer to the affected areas of the skin 1-3 times a day, depending on the severity of the condition, and gently rubbed. In most cases, to achieve the effect, it is enough to apply 1-2 times a day. The frequency of application of the drug is determined according to the degree of damage. With a mild degree of damage, the drug can be applied once a day, in case of more severe lesions, the frequency of application of the drug must be increased.

The duration of the course of treatment is determined by the doctor, depending on the severity and course of the disease, until improvements are noticeable, but not more than 4 weeks.

Treatment with Nobetasone cream should be stopped gradually, as soon as the effect is achieved, then maintenance therapy is recommended by applying the cream 1 time per day and not more than 2 times a week.

With a sharp cessation of treatment with the drug, dermatosis may reappear.

The method of application in children is the same as in adults, but the course of treatment should be short and less active compared to adults (see sections "Contraindications" and "Special Instructions").

Side effects

- burning sensation

- skin irritation

- itching

-dry skin

- folliculitis

- hypertrichosis

- acne breakouts

-hypopigmentation

- perioral dermatitis

- allergic contact dermatitis

- skin maceration

- secondary infection

- skin atrophy

- striae

- myalgia

Side effects in children

- inhibition of the function of the hypothalamic-pituitary-adrenal system

- Cushing's syndrome

- growth retardation

- lag in weight gain

- increased intracranial pressure.

Contraindications

- hypersensitivity to any component of the drug

- children's age up to 6 months

- pregnancy (use of high doses, long-term treatment) and lactation

- untreated skin infections

- juvenile acne

Drug Interactions

Co-administration of drugs that can inhibit CYP3A4 (eg, ritonavir, itraconazole) generally inhibits the metabolism of corticosteroids and results in increased systemic exposure. The extent to which this interaction is clinically significant depends on the dose and routes of administration of corticosteroids, as well as the potential inhibitor of CYP3A4.

Special instructions

The drug is not intended for use in ophthalmology. When using the drug in the eyelids, make sure that the drug does not get into the eyes, as cataracts and glaucoma may develop as a result of repeated exposure.

If irritation or hypersensitivity is noted during the use of the drug, treatment should be discontinued and another therapy should be selected for the patient.

In the presence of an infection, antifungal or antibacterial agents should be prescribed, respectively. If at the same time the desired effect does not occur quickly, the use of corticosteroids should be stopped until the signs of infection have disappeared.

Any side effects that occur with systemic use of glucocorticoids, including suppression of the adrenal cortex, can also occur with their topical use, especially in infants and children.

Systemic absorption of topical corticosteroids may be increased when they are used for a long time, when treating a large body surface, or when using occlusive dressings.

Application in pediatrics

Children may be more susceptible to the action of local glucocorticosteroids, which cause depression of the hypothalamic-pituitary-adrenal system, than older patients. This is due to the higher absorption of the drug in children due to the greater ratio of surface area to body weight. In infants and children, systemic absorption of topical glucocorticosteroids may be increased with prolonged use, treatment of large areas of the body, or use of dressings.

Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms

The drug does not affect the ability to drive vehicles or complex technical devices.

Overdose

Symptoms. Excessive or prolonged use of topical glucocorticosteroids can cause depression of the pituitary-adrenal function, which can lead to the development of secondary adrenal insufficiency and the appearance of symptoms of hypercorticism, including Cushing's syndrome.

Treatment: Symptomatic treatment. If necessary, correction of electrolyte imbalance is indicated. In the case of chronic toxic effects, a gradual withdrawal of glucocorticosteroids is recommended.

Storage conditions

Store at a temperature not exceeding 25°C, in a dry, dark place.

Keep out of the reach of children!

Shelf life - 2 years

Do not use the drug after the expiration date.