Nimulid® (Nimesulide) 100 mg, 30 tablets
- $11.00
Nimulid® (Nimesulide) is a nonsteroidal anti-inflammatory drugs, also called as NSAID, effective in the treatment of a range of inflammatory and painful conditions, including acute pain and primary dysmenorrhea. This medicine works by blocking the enzyme activity (cyclooxygenase 1 and cyclooxygenase 2) which generates pain signals in the body. This medicine helps by exerting pain killing actions.
Other brand names: Sulide, Nimalox, Nilsid, Mesulid, Drexel, Donulide, Aulin, Ainex, Heugan, Mesulid, Minapon, NeRelid, Edrigyl, Enetra, Eskaflam, Nexen, Nidolon, Nilden, Nise
One tablet contains the active ingredient - nimesulide 100 mg,
excipients: lactose monohydrate, croscarmellose sodium, colloidal silicon dioxide, corn starch, polyvidone K-30, sodium dokuzat, polysorbate-80, magnesium stearate.
- acute pain
- painful symptoms of osteoarthritis (including rheumatoid arthritis), osteoarthritis, bursitis, tendinitis
- pain syndrome in the postoperative period, with injuries, diseases of the ear, throat, nose, in dentistry, gynecology
Always take NIMULID as directed by your doctor. The usual dose is 1 tablet (100mg) 2 times a day by mouth after meals.
It is recommended to take the drug for a short period of time.
Often
- diarrhea
- increase in liver function tests
Rarely
- headache, dizziness, drowsiness
- anemia and eosinophilia
- hyperkalemia
- fear, nervousness, nightmares
- blurry vision
- tachycardia
- hypersensitivity
- erythema, dermatitis, exanthema, petechiae, purpura
- dysuria (pain or difficulty urinating), hematuria (presence of blood in the urine), urinary retention, oliguria
- constipation, flatulence, gastritis, nausea, vomiting, heartburn, stomach pain, tarry stools, melena
Very rarely
- increased blood pressure, fluctuation in blood pressure, hemorrhage
- itching, skin rash
- increased sweating, edema
shortness of breath
- malaise, asthenia
- liver failure
- thrombocytopenia
- hypersensitivity (allergy) to Nimulid and others
components of Nimulid
- allergic reactions (wheezing, runny or stuffy nose, hives or rash) to aspirin or other nonsteroidal anti-inflammatory drugs
- "aspirin" asthma
- severe liver dysfunction or increased levels of liver enzymes
- combined use with other drugs that affect liver function
- alcohol abuse
- peptic ulcers (peptic ulcer of the stomach and duodenum) in the acute phase, bleeding of the stomach or intestines
- cerebral hemorrhage (stroke)
- any problems associated with bleeding or blood clotting
- severe renal dysfunction (with Cl creatinine less than 30 ml / min)
- heart failure, arterial hypertension
- visual impairment
- non-insulin dependent diabetes mellitus
- pregnancy
- lactation / lactation period
- children under the age of 18
Nimulide can enhance the efficacy and toxicity of many drugs, as a result of displacement from the binding sites with plasma proteins and, thus, an increase in their free fraction in the blood. It is prescribed with caution with anticoagulants, hypoglycemic agents, digoxin, phenytoin, lithium preparations, diuretics, antihypertensive drugs, other non-steroidal anti-inflammatory drugs, cyclosporine, methotrexate. There is no clinically significant interaction of Nimulide with furosemide, warfarin, digoxin, theophylline, cimetidine, antacids.
Nimulide has a high similarity to blood plasma proteins, therefore, it can prevent the binding of other drugs taken simultaneously with Nimesulide with plasma proteins and change their pharmacokinetic profile. Nimulide increases the concentration of drugs competing for protein binding.
During treatment with Nimulid, symptoms may develop (loss of appetite, nausea, vomiting, abdominal pain, fatigue or dark urine), which indicate impaired liver function, and you should stop taking Nimulid and immediately inform your doctor. If the patient has ever suffered from peptic ulcers, bleeding of the stomach or intestines, ulcerative colitis, they should inform the doctor about this before taking Nimulid. It is prescribed with caution to elderly patients, with cardiovascular diseases, including arterial hypertension, a tendency to bleeding, pathology of the upper gastrointestinal tract, impaired renal function (dose reduction is recommended), against the background of treatment with anticoagulants and antiplatelet agents. If the patient suffers from heart or renal failure, the doctor should be informed before using Nimulide, as renal function may deteriorate. If the patient is elderly, the doctor should monitor while taking the drug to make sure that Nimulide does not cause stomach, kidney, heart or liver disorders.
If visual impairment occurs, you should immediately stop taking the drug and consult an ophthalmologist.
If there is an intolerance to some sugars, the patient should inform the doctor before using the drug. Patients on a low-calorie diet should take into account that the drug contains lactose.
Avoid alcohol abuse during treatment with Nimulide, as alcohol can increase the risk of developing liver disorders
If the patient plans to become pregnant, he must inform the doctor as Nimulide may reduce fertility.
Abrupt withdrawal of the drug may cause ischemia of the heart with exacerbation of angina pectoris or arterial hypertension or provoke myocardial infarction. With this in mind, drug withdrawal should be carried out strictly under the supervision of the attending physician and gradually.
Impact on the ability to drive and use vehicles
Nimulide can cause dizziness, therefore, when using it, you should refrain from driving a car and working with mechanisms that require precise coordination of movements.
Symptoms: increased severity of side effects.
Treatment: gastric lavage, the appointment of activated carbon.
Store in a dry, dark place at a temperature not exceeding + 25 ° C.
Keep the drug out of the reach of children!
Shelf life - 60 months
Do not use after the expiration date printed on the package.
Other brand names: Sulide, Nimalox, Nilsid, Mesulid, Drexel, Donulide, Aulin, Ainex, Heugan, Mesulid, Minapon, NeRelid, Edrigyl, Enetra, Eskaflam, Nexen, Nidolon, Nilden, Nise
Composition
One tablet contains the active ingredient - nimesulide 100 mg,
excipients: lactose monohydrate, croscarmellose sodium, colloidal silicon dioxide, corn starch, polyvidone K-30, sodium dokuzat, polysorbate-80, magnesium stearate.
Indications
- acute pain
- painful symptoms of osteoarthritis (including rheumatoid arthritis), osteoarthritis, bursitis, tendinitis
- pain syndrome in the postoperative period, with injuries, diseases of the ear, throat, nose, in dentistry, gynecology
Method of administration and dosage
Always take NIMULID as directed by your doctor. The usual dose is 1 tablet (100mg) 2 times a day by mouth after meals.
It is recommended to take the drug for a short period of time.
Side effects
Often
- diarrhea
- increase in liver function tests
Rarely
- headache, dizziness, drowsiness
- anemia and eosinophilia
- hyperkalemia
- fear, nervousness, nightmares
- blurry vision
- tachycardia
- hypersensitivity
- erythema, dermatitis, exanthema, petechiae, purpura
- dysuria (pain or difficulty urinating), hematuria (presence of blood in the urine), urinary retention, oliguria
- constipation, flatulence, gastritis, nausea, vomiting, heartburn, stomach pain, tarry stools, melena
Very rarely
- increased blood pressure, fluctuation in blood pressure, hemorrhage
- itching, skin rash
- increased sweating, edema
shortness of breath
- malaise, asthenia
- liver failure
- thrombocytopenia
Contraindications
- hypersensitivity (allergy) to Nimulid and others
components of Nimulid
- allergic reactions (wheezing, runny or stuffy nose, hives or rash) to aspirin or other nonsteroidal anti-inflammatory drugs
- "aspirin" asthma
- severe liver dysfunction or increased levels of liver enzymes
- combined use with other drugs that affect liver function
- alcohol abuse
- peptic ulcers (peptic ulcer of the stomach and duodenum) in the acute phase, bleeding of the stomach or intestines
- cerebral hemorrhage (stroke)
- any problems associated with bleeding or blood clotting
- severe renal dysfunction (with Cl creatinine less than 30 ml / min)
- heart failure, arterial hypertension
- visual impairment
- non-insulin dependent diabetes mellitus
- pregnancy
- lactation / lactation period
- children under the age of 18
Drug interactions
Nimulide can enhance the efficacy and toxicity of many drugs, as a result of displacement from the binding sites with plasma proteins and, thus, an increase in their free fraction in the blood. It is prescribed with caution with anticoagulants, hypoglycemic agents, digoxin, phenytoin, lithium preparations, diuretics, antihypertensive drugs, other non-steroidal anti-inflammatory drugs, cyclosporine, methotrexate. There is no clinically significant interaction of Nimulide with furosemide, warfarin, digoxin, theophylline, cimetidine, antacids.
Nimulide has a high similarity to blood plasma proteins, therefore, it can prevent the binding of other drugs taken simultaneously with Nimesulide with plasma proteins and change their pharmacokinetic profile. Nimulide increases the concentration of drugs competing for protein binding.
Special instructions
During treatment with Nimulid, symptoms may develop (loss of appetite, nausea, vomiting, abdominal pain, fatigue or dark urine), which indicate impaired liver function, and you should stop taking Nimulid and immediately inform your doctor. If the patient has ever suffered from peptic ulcers, bleeding of the stomach or intestines, ulcerative colitis, they should inform the doctor about this before taking Nimulid. It is prescribed with caution to elderly patients, with cardiovascular diseases, including arterial hypertension, a tendency to bleeding, pathology of the upper gastrointestinal tract, impaired renal function (dose reduction is recommended), against the background of treatment with anticoagulants and antiplatelet agents. If the patient suffers from heart or renal failure, the doctor should be informed before using Nimulide, as renal function may deteriorate. If the patient is elderly, the doctor should monitor while taking the drug to make sure that Nimulide does not cause stomach, kidney, heart or liver disorders.
If visual impairment occurs, you should immediately stop taking the drug and consult an ophthalmologist.
If there is an intolerance to some sugars, the patient should inform the doctor before using the drug. Patients on a low-calorie diet should take into account that the drug contains lactose.
Avoid alcohol abuse during treatment with Nimulide, as alcohol can increase the risk of developing liver disorders
If the patient plans to become pregnant, he must inform the doctor as Nimulide may reduce fertility.
Abrupt withdrawal of the drug may cause ischemia of the heart with exacerbation of angina pectoris or arterial hypertension or provoke myocardial infarction. With this in mind, drug withdrawal should be carried out strictly under the supervision of the attending physician and gradually.
Impact on the ability to drive and use vehicles
Nimulide can cause dizziness, therefore, when using it, you should refrain from driving a car and working with mechanisms that require precise coordination of movements.
Overdose
Symptoms: increased severity of side effects.
Treatment: gastric lavage, the appointment of activated carbon.
Storage conditions
Store in a dry, dark place at a temperature not exceeding + 25 ° C.
Keep the drug out of the reach of children!
Shelf life - 60 months
Do not use after the expiration date printed on the package.
Scientific Studies
- https://en.wikipedia.org/wiki/Nimesulide
- https://go.drugbank.com/drugs/DB04743
- https://pubmed.ncbi.nlm.nih.gov/16846549/
- https://pubmed.ncbi.nlm.nih.gov/30677025/
- https://pubmed.ncbi.nlm.nih.gov/7506151/
- https://pubmed.ncbi.nlm.nih.gov/21030939/
- https://pubmed.ncbi.nlm.nih.gov/9255005/
- https://pubmed.ncbi.nlm.nih.gov/7506198/
- https://pubmed.ncbi.nlm.nih.gov/7506147/
- https://pubmed.ncbi.nlm.nih.gov/11573855/
- https://pubmed.ncbi.nlm.nih.gov/14655069/
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