The instruction for medical use of Momat Torgovoye medicine a name Momat Mezhdunarodnoye the unlicensed name Mometazon Lekarstvennaya a form Ointment, 5 g and 15 g Structure of 1 grams of ointment contains active agent - a mometazon furoate of 1 mg, excipients: paraffin white soft, wax white bee, propylene glycol monostearate. Description Ointment of white color. Pharmacotherapeutic group Glucocorticosteroids for topical treatment of diseases of skin. Glucocorticosteroids active (Group III). Mometazon. ATX D07AC13 code Pharmacological Momat Asborbtion's Pharmacokinetics properties of ointment insignificant. In 8 hours after single drawing on the uninjured skin (without occlusive bandage) in a system blood-groove about 0.7% of active agent are found. Extent of absorption increases when putting drug by the big surface area of skin and when using a hermetic bandage. Extent of absorption at children is higher as the ratio of surface area of skin to the body weight of the child is more, than at adults. Metabolism: the mometazona furoate is intensively metabolized in a liver. Removal: it is removed mainly by kidneys and in insignificant quantity with bile. Elimination half-life makes about 5.8 h. The pharmacodynamics Momat ointment - galogensoderzhashchy monoester, is a synthetic corticosteroid, possessing anti-inflammatory, antipruritic and anti-exudative action. The glucocorticosteroid induces discharge of the proteins inhibiting a phospholipase A 2 and known under the general name of a lipokortina which control biosynthesis of such mediators of inflammation as prostaglandins and leukotrienes, by slowing down of release of their common precursor, arachidonic acid. Corticosteroids suppress an accumulation and further migration of cells in the field of damage and also eliminate expansion and hyperpermeability of vessels in the field of damage that reduces access of cells to sites of damage of fabrics. In addition, corticosteroids can also prevent access of sensibilized T lymphocytes and macrophages to skin cells. Anti-proliferative action reduces a hyperplasia of cells in psoriasis. Indications - the inflammatory phenomena and an itching at a dermatosis - psoriasis, atopic dermatitis - contact dermatitis of the allergic and not allergic nature the Route of administration and doses Momat apply ointment a thin layer on an affected area once a day. Duration of a course of treatment drug depends on disease severity and is regulated by the attending physician. Side effects Seldom - irritation and xeroderma, burning sensation, an itching, a folliculitis, a hypertrichosis, acne rash - hypopigmentation, perioral dermatitis, maceration of skin, accession of consecutive infection - an atrophy of skin, a striya, a heat rash Very seldom - papulation - adrenal insufficiency and Cushing's syndrome (at ointment use for a long time and/or for treatment of big sites of skin, or with use of occlusive bandages, especially at children and teenagers) Contraindications - hypersensitivity to a mometazon to furoate and to other components of drug, or to corticosteroids - pink eels, perioral dermatitis - bacterial, virus (Herpes simplex, chicken pox, Herpes zoster) or a fungal infection of skin - tuberculosis, syphilis - vaccine-challenged reactions - disturbance of integrity of an integument - children's age up to 2 years - pregnancy and the period of a lactation Medicinal interactions of the Research of medicinal interaction Momat of ointment with other drugs were not carried out. Special instructions It is necessary to avoid hit Momat of ointment in eyes. When drawing on big sites of skin for a long time, especially at use of occlusive bandages, development of systemic action of a mometazon is possible. Considering it, patients have to be observed concerning signs of suppression of function gipotalamo - the hypophysial and adrenal system and development of a syndrome of Cushing. The propylene glycol which is a part of drug can cause irritation in the site of application, in such cases it is necessary to stop use of Momat ointment and to appoint the corresponding treatment. It is necessary to consider that a glucocorticosteroid - the containing ointments are capable to change manifestations of some diseases of skin that can complicate diagnosis and besides, be the cause of a delay of healing of wounds. At long therapy Momat ointment can lead the sudden termination of therapy ment of a syndrome of the ricochet which is shown in the form of dermatitis with intensive erubescence and burning sensation. Therefore after a long course of treatment the drug withdrawal should be made gradually, for example, passing to the intermittent scheme of treatment before completely to stop it. Use in pediatrics Only on doctor's orders. Because children have a size of a ratio of surface area and body weight it is more, than at adults, children are subject to bigger risk of suppression of function gipotalamo - the hypophysial and adrenal system and development of a syndrome of Cushing at use of any glucocorticosteroids for local action. Momat ointment at children can lead long-term treatment to disturbances of their growth and development. Duration of treatment should not exceed 5 days. Children have to receive the minimum dose of drug sufficient for achievement of effect, it is impossible to apply occlusive bandages. Features of influence of medicine on ability to run motor transport or other potentially dangerous mechanisms are not revealed Overdose Symptoms - function oppression gipotalamo - a hypophysial and adrenal system, including secondary adrenal insufficiency. Treatment is symptomatic, if necessary – correction of an electrolytic imbalance, drug withdrawal (at long therapy – gradual cancellation). The form of release and packing On 5 g or 15 g of drug place in an aluminum tuba. On 1 tuba together with the instruction for medical use in the state and Russian languages put in a pack from cardboard. To Store storage conditions in the dry, protected from light place at a temperature not over 250C. Not to freeze. To store out of children's reach! 2 years not to apply a period of storage after an expiration date. Prescription status According to the prescription of Proizvoditel Glenmark Pharmasyyutikalz Ltd, the RAFT No. E 37.39, MIDS of Area, Satpur, Nasik – 422007, Maharashtra, India. The owner of the registration certificate of Glenmark Pharmasyyutikalz Ltd, India the Address of the organization accepting in the territory of the Republic of Kazakhstan claims on quality of products from a potrebiteleypredstavitelstvo of Glenmark Pharmasyyutikalz LTD in RK, 050005, Almaty, Al-Farabi Avenue, 7, business center of Nurla Tau, block 4 A, office 7.
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