Meksim® 100 mg (30 tablets)
- $9.70
The instruction for medical use
of MEKSIM® medicine
Trade name
МЕКСИМ®
the International unlicensed
name Nimesulide Dosage Form
of the Tablet, 100 mg
Structure
One tablet contains
active agent - Nimesulide of 100 mg,
excipients: sodium carboxymethylcellulose, cellulose microcrystalline PH 102, lactose anhydrous, aerosil 200, explotab, magnesium stearate.
The description
Round flat tablets of light yellow color with slightly marble surface, with a bilateral facet and risky on one party.
The pharmacotherapeutic group
Other non-steroidal anti-inflammatory drugs
the Code of automatic telephone exchange M01AX17
the Pharmacological
Pharmacokinetics МЕКСИМ® properties quickly and almost is completely absorbed after reception.
After oral administration of 100-200 mg the average maximum plasma concentration (C max) are reached in 2-3 hours (t max). More than 97.5% of Nimesulide are in blood connected with proteins of plasma. After absorption, Nimesulide is distributed in extracellular liquid. Thus, concentration in synovial fluid reaches 44% in 12 hours and remains longer in synovial fluid, than in plasma.
Elimination half-life (t1/2) makes from 3.2 to 6 hours. Nimesulide is extensively metabolized in a liver to the main metabolite of 4-IT-Nimesulide which also has considerable anti-inflammatory activity. Only 1-3% of a dose are excreted in not changed view with urine. 70% of metabolites are removed with urine and 29% are removed with excrements.
Pharmacodynamics
МЕКСИМ® - non-steroidal anti-inflammatory drug (NPVS). The chemical structure of Nimesulide differs from other NPVS in what does not support carboxyl group in the structure, and contains sulfonanilidny group. Nimesulide selectively inhibits cyclooxygenase-2 (TsOG-2) which is responsible for formation of prostaglandins from arachidonic acid. Effect of drug мексим® is explained by inhibition of synthesis of prostaglandins which play a key role in inflammation, appearance of pain and temperature increase. The physiological role of prostaglandins consists in participation in protective mechanisms, such as maintenance of blood supply of fabrics, homeostasis, integrity mucous a stomach, functions of kidneys and inflammation. Nimesulide has anti-inflammatory, soothing and febrifugal activity. The activity of binding of free radicals Nimesulide promotes the anti-inflammatory action caused by suppression of prostaglandins. Education of free radicals due to activation of neutrophils is suppressed with Nimesulide without influence on their phagocytal activity or hemotoksichny activity. In addition considerably the activity of synthesis of myeloperoxidase decreases.
Indications
- arthritises of various etiology (including. rheumatoid and psoriasis)
- an osteoarthrosis
- a joint syndrome&
to Develop nbs
of MEKSIM® medicine
Trade name
МЕКСИМ®
the International unlicensed
name Nimesulide Dosage Form
of the Tablet, 100 mg
Structure
One tablet contains
active agent - Nimesulide of 100 mg,
excipients: sodium carboxymethylcellulose, cellulose microcrystalline PH 102, lactose anhydrous, aerosil 200, explotab, magnesium stearate.
The description
Round flat tablets of light yellow color with slightly marble surface, with a bilateral facet and risky on one party.
The pharmacotherapeutic group
Other non-steroidal anti-inflammatory drugs
the Code of automatic telephone exchange M01AX17
the Pharmacological
Pharmacokinetics МЕКСИМ® properties quickly and almost is completely absorbed after reception.
After oral administration of 100-200 mg the average maximum plasma concentration (C max) are reached in 2-3 hours (t max). More than 97.5% of Nimesulide are in blood connected with proteins of plasma. After absorption, Nimesulide is distributed in extracellular liquid. Thus, concentration in synovial fluid reaches 44% in 12 hours and remains longer in synovial fluid, than in plasma.
Elimination half-life (t1/2) makes from 3.2 to 6 hours. Nimesulide is extensively metabolized in a liver to the main metabolite of 4-IT-Nimesulide which also has considerable anti-inflammatory activity. Only 1-3% of a dose are excreted in not changed view with urine. 70% of metabolites are removed with urine and 29% are removed with excrements.
Pharmacodynamics
МЕКСИМ® - non-steroidal anti-inflammatory drug (NPVS). The chemical structure of Nimesulide differs from other NPVS in what does not support carboxyl group in the structure, and contains sulfonanilidny group. Nimesulide selectively inhibits cyclooxygenase-2 (TsOG-2) which is responsible for formation of prostaglandins from arachidonic acid. Effect of drug мексим® is explained by inhibition of synthesis of prostaglandins which play a key role in inflammation, appearance of pain and temperature increase. The physiological role of prostaglandins consists in participation in protective mechanisms, such as maintenance of blood supply of fabrics, homeostasis, integrity mucous a stomach, functions of kidneys and inflammation. Nimesulide has anti-inflammatory, soothing and febrifugal activity. The activity of binding of free radicals Nimesulide promotes the anti-inflammatory action caused by suppression of prostaglandins. Education of free radicals due to activation of neutrophils is suppressed with Nimesulide without influence on their phagocytal activity or hemotoksichny activity. In addition considerably the activity of synthesis of myeloperoxidase decreases.
Indications
- arthritises of various etiology (including. rheumatoid and psoriasis)
- an osteoarthrosis
- a joint syndrome&
to Develop nbs
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