Loperamide hydrochloride 0.002g (20 tablets)
- $2.70
The instruction for medical use
of medicine
of Loperamide a hydrochloride of LH
the Trade name
of Loperamide a hydrochloride of LH
the International unlicensed
name Loperamide Dosage Form
of the Tablet, 0.002 g
Structure
One tablet contains
active agent - loperamide a hydrochloride of 0.002 g,
excipients: lactoses monohydrate, starch corn, magnesium stearate, stearic acid, polyvinylpirrolidone low-molecular medical.
The description
of the Tablet from color, white to white with a yellowish shade,
Pharmacotherapeutic group
Antidiarrheal drugs. The drugs reducing motility of digestive tract. Loperamide
the ATX A07DA03 Code
the Pharmacological
Pharmacokinetics Loperamide properties easily and almost is completely soaked up from intestines. The maximum concentration in blood plasma is defined in 4 hours. Badly gets through a blood-brain barrier. It is removed generally with a stake, partially with urine.
The pharmacodynamics
Loperamide has anti-diarrheal effect.
Drug has also anti-secretory action, raises a tone of an anal sphincter.
Reduces a tone and motility of smooth muscles of intestines, at the expense of inhibition of release of acetylcholine and prostaglandins owing to linking of drug with opiate receptors of an intestinal wall. Drug raises a tone of an anal sphincter. Effect of drug comes quickly and 4 – 6 hours proceed. Drug does not get through a blood-brain barrier.
Indications
- symptomatic treatment of acute and chronic diarrhea of various genesis (allergic, psychosomatic, medicinal, beam, at change of a diet and qualitative structure of food, at disturbance of metabolism and absorption, when imposing an ileostoma and also at not septic form of a syndrome of irritation of a large intestine, ulcer colitis)
- as supportive application, in diarrhea of the infectious nature
the initial dose for adults makes the Route of administration and doses In sharp cases of diarrhea: 2 tablets. For children over 6 years 1 tablet, then on 1 tablet (2 mg) after each act of defecation. In chronic diarrhea an initial dose for adults-2 of a tablet (4 mg), for children-1 tablet (2 mg) daily, then establish a maintenance dose before receiving a calla of normal consistence 1-2 times a day. The maximum daily dose in acute and chronic diarrhea - no more than 6 tablets (15 mg) for adults and three tablets (6 mg) on 20 kg of body weight - for children. After receiving normal defecation or in the absence of defecation within 12 hours the administration of drug is stopped.
Side effects
- a headache, dizziness, increased fatigue, drowsiness or insomnia, an oppression/loss of consciousness, spasms, a tremor
- spasms and gripes in a stomach, dyspepsia, nausea, vomiting, Ilheus, a meteorism, a constipation
- dryness in a mouth
it is rare
- an ischuria
- bullous rashes, including Stephens-Johnson's syndrome, a multiformny erythema, a toxic epidermal necrolysis
Very seldom
- paralytic intestinal impassability, the accelerated formation of toxic megacolon
- an acute anaphylaxis and anaphylactoid reactions
- lengthening of an interval QT, a sudden cardiac death, serious ventricular arrhythmias
of the Contraindication
- hypersensitivity to drug components
- states at which oppression of a vermicular movement because of possible risk of emergence of considerable complications is undesirable, including intestinal impassability, megacolon and toxic megacolon
- the acute ulcer colitis or pseudomembranous colitis connected with use of antibiotics of a wide range of action - the acute dysentery and other bacterial coloenterites caused by microorganisms of the Salmonella, Shigella and Campylobacter families
- pregnancy and the period of a lactation
- children's age up to 6 years
Medicinal interactions
on purpose avoidance of mutual strengthening of effect, it is not recommended to appoint Loperamide a hydrochloride along with m - cholinolytic drugs (atropine). Together with inhibitors of R-glycoproteins (quinidine, ritonavir) led hydrochloride Loperamide co-administration (in a dose of 16 mg) to increase in level of loperamide in blood plasma by 2-3 times. The clinical importance of noted pharmacokinetic interaction at use of loperamide in the recommended doses (from 2 mg to 16 mg) is unknown.
Special instructions
At treatment of diarrhea it is necessary to take measures for substitution of the lost water and electrolytes, to adhere to a diet. In abnormal liver functions it is necessary to consult with the doctor concerning drug use.
Cautions at use
Loperamide is intended only for symptomatic treatment of ponos. If the cause of illness is known, use of etiotropic means is necessary. Drug does not replace antibacterial treatment in infectious diseases of intestines. It is not applied to initial therapy of acute dysentery (the profound fever, blood kcal). In acute diarrhea if for 48 hours the improvement did not occur, it is necessary to stop administration of drug and to see behind consultation a doctor.
Features of influence of medicine on ability to run vehicles and to work with difficult mechanisms.
Loperamide does not influence speed of response at control of motor transport or work with other mechanisms. However in case of fatigue, drowsiness or dizziness it is not recommended to drive the car or to work with a difficult technique.
Overdose
Symptoms: oppression of central nervous system (stupor, lack of coordination, drowsiness, miosis, muscular hypertension, respiratory depression), intestinal impassability. Treatment: as antidote use Naloxonum. Considering that duration of effect of loperamide is more than at Naloxonum, perhaps repeated introduction of the antagonist. Right after overdose enter activated carbon and wash out a stomach, if necessary support breath function.
The form of release and packing
On 10 tablets place in blister strip packaging from a film of the polyvinylchloride and printing aluminum foil varnished.
One or two blister strip packagings together with the instruction for medical use are placed in a pack from cardboard.
To Store storage conditions in the place protected from light at a temperature not over 250C
to Store out of children's reach!
Not to apply a period of storage of 5 years after expiry date
Prescription status
According to the prescription
JSC Lekkhim-Kharkiv Producer, Ukraine, 61115. Kharkiv, 17th Partsjezda St., 36
the Owner of the registration certificate
of JSC Lekkhim-Kharkiv, Ukraine
the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods)
of Medicus Centre LLP
050000, Almaty, Mussorgsky St., 2A
ph. +007 (7272) 71-48-12, 71 48 13
e-mail: postavki@medicus.kz
of medicine
of Loperamide a hydrochloride of LH
the Trade name
of Loperamide a hydrochloride of LH
the International unlicensed
name Loperamide Dosage Form
of the Tablet, 0.002 g
Structure
One tablet contains
active agent - loperamide a hydrochloride of 0.002 g,
excipients: lactoses monohydrate, starch corn, magnesium stearate, stearic acid, polyvinylpirrolidone low-molecular medical.
The description
of the Tablet from color, white to white with a yellowish shade,
Pharmacotherapeutic group
Antidiarrheal drugs. The drugs reducing motility of digestive tract. Loperamide
the ATX A07DA03 Code
the Pharmacological
Pharmacokinetics Loperamide properties easily and almost is completely soaked up from intestines. The maximum concentration in blood plasma is defined in 4 hours. Badly gets through a blood-brain barrier. It is removed generally with a stake, partially with urine.
The pharmacodynamics
Loperamide has anti-diarrheal effect.
Drug has also anti-secretory action, raises a tone of an anal sphincter.
Reduces a tone and motility of smooth muscles of intestines, at the expense of inhibition of release of acetylcholine and prostaglandins owing to linking of drug with opiate receptors of an intestinal wall. Drug raises a tone of an anal sphincter. Effect of drug comes quickly and 4 – 6 hours proceed. Drug does not get through a blood-brain barrier.
Indications
- symptomatic treatment of acute and chronic diarrhea of various genesis (allergic, psychosomatic, medicinal, beam, at change of a diet and qualitative structure of food, at disturbance of metabolism and absorption, when imposing an ileostoma and also at not septic form of a syndrome of irritation of a large intestine, ulcer colitis)
- as supportive application, in diarrhea of the infectious nature
the initial dose for adults makes the Route of administration and doses In sharp cases of diarrhea: 2 tablets. For children over 6 years 1 tablet, then on 1 tablet (2 mg) after each act of defecation. In chronic diarrhea an initial dose for adults-2 of a tablet (4 mg), for children-1 tablet (2 mg) daily, then establish a maintenance dose before receiving a calla of normal consistence 1-2 times a day. The maximum daily dose in acute and chronic diarrhea - no more than 6 tablets (15 mg) for adults and three tablets (6 mg) on 20 kg of body weight - for children. After receiving normal defecation or in the absence of defecation within 12 hours the administration of drug is stopped.
Side effects
- a headache, dizziness, increased fatigue, drowsiness or insomnia, an oppression/loss of consciousness, spasms, a tremor
- spasms and gripes in a stomach, dyspepsia, nausea, vomiting, Ilheus, a meteorism, a constipation
- dryness in a mouth
it is rare
- an ischuria
- bullous rashes, including Stephens-Johnson's syndrome, a multiformny erythema, a toxic epidermal necrolysis
Very seldom
- paralytic intestinal impassability, the accelerated formation of toxic megacolon
- an acute anaphylaxis and anaphylactoid reactions
- lengthening of an interval QT, a sudden cardiac death, serious ventricular arrhythmias
of the Contraindication
- hypersensitivity to drug components
- states at which oppression of a vermicular movement because of possible risk of emergence of considerable complications is undesirable, including intestinal impassability, megacolon and toxic megacolon
- the acute ulcer colitis or pseudomembranous colitis connected with use of antibiotics of a wide range of action - the acute dysentery and other bacterial coloenterites caused by microorganisms of the Salmonella, Shigella and Campylobacter families
- pregnancy and the period of a lactation
- children's age up to 6 years
Medicinal interactions
on purpose avoidance of mutual strengthening of effect, it is not recommended to appoint Loperamide a hydrochloride along with m - cholinolytic drugs (atropine). Together with inhibitors of R-glycoproteins (quinidine, ritonavir) led hydrochloride Loperamide co-administration (in a dose of 16 mg) to increase in level of loperamide in blood plasma by 2-3 times. The clinical importance of noted pharmacokinetic interaction at use of loperamide in the recommended doses (from 2 mg to 16 mg) is unknown.
Special instructions
At treatment of diarrhea it is necessary to take measures for substitution of the lost water and electrolytes, to adhere to a diet. In abnormal liver functions it is necessary to consult with the doctor concerning drug use.
Cautions at use
Loperamide is intended only for symptomatic treatment of ponos. If the cause of illness is known, use of etiotropic means is necessary. Drug does not replace antibacterial treatment in infectious diseases of intestines. It is not applied to initial therapy of acute dysentery (the profound fever, blood kcal). In acute diarrhea if for 48 hours the improvement did not occur, it is necessary to stop administration of drug and to see behind consultation a doctor.
Features of influence of medicine on ability to run vehicles and to work with difficult mechanisms.
Loperamide does not influence speed of response at control of motor transport or work with other mechanisms. However in case of fatigue, drowsiness or dizziness it is not recommended to drive the car or to work with a difficult technique.
Overdose
Symptoms: oppression of central nervous system (stupor, lack of coordination, drowsiness, miosis, muscular hypertension, respiratory depression), intestinal impassability. Treatment: as antidote use Naloxonum. Considering that duration of effect of loperamide is more than at Naloxonum, perhaps repeated introduction of the antagonist. Right after overdose enter activated carbon and wash out a stomach, if necessary support breath function.
The form of release and packing
On 10 tablets place in blister strip packaging from a film of the polyvinylchloride and printing aluminum foil varnished.
One or two blister strip packagings together with the instruction for medical use are placed in a pack from cardboard.
To Store storage conditions in the place protected from light at a temperature not over 250C
to Store out of children's reach!
Not to apply a period of storage of 5 years after expiry date
Prescription status
According to the prescription
JSC Lekkhim-Kharkiv Producer, Ukraine, 61115. Kharkiv, 17th Partsjezda St., 36
the Owner of the registration certificate
of JSC Lekkhim-Kharkiv, Ukraine
the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods)
of Medicus Centre LLP
050000, Almaty, Mussorgsky St., 2A
ph. +007 (7272) 71-48-12, 71 48 13
e-mail: postavki@medicus.kz
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