Longidaza® (Bovhyaluronidase Azoximer) 3000 IU, 10 suppositories

What Is Longidaza® (Bovhyaluronidase Azoximer) 3000 IU Suppositories?

Longidaza® is a medical product designed to treat various conditions associated with inflammation and excessive connective tissue growth, such as fibrosis and adhesions.

Its active ingredient, bovhyaluronidase azoximer, provides prolonged anti-fibrotic and anti-inflammatory effects, making it effective in both treating and preventing these issues. The formula works by breaking down excess connective tissue, reducing the risk of fibrosis, and easing inflammation, which contributes to improved tissue flexibility and function.

Longidaza®’s innovative multi-component composition is what sets it apart. By combining the enzyme hyaluronidase with a high-molecular carrier, the medication achieves increased stability and a more extended duration of action compared to traditional enzyme therapies.

This combination allows Longidaza® to:

• Prevent the formation of new adhesions
• Soften and make existing adhesions more elastic
• Enhance the effectiveness of other treatments, such as antibiotics, by improving tissue permeability and bioavailability

In addition, Longidaza® is known for its gentle action on healthy connective tissue, targeting only the affected areas without causing damage. This feature, along with its high safety profile, makes Longidaza® suitable for both acute and chronic phases of conditions involving tissue overgrowth and inflammation.

What Are the Key Benefits of Longidaza®?

Longidaza® offers a wide range of therapeutic benefits, including:

• Reduction in Adhesion Formation: Longidaza® effectively helps prevent new adhesions and alters the structure of existing ones, making them more elastic and reducing the risks associated with connective tissue fibrosis.
• Enhanced Drug Penetration: The formula increases tissue permeability, improving the effectiveness of antibacterial therapies by enabling deeper delivery to inflammation sites.
• Anti-inflammatory and Edema-reducing Effects: Longidaza® supports improved microcirculation within tissues, which helps decrease swelling and ease inflammation, even in the acute phase of disease.

What Makes Longidaza® Unique?

The innovative composition of Longidaza® comprises two main components:

1. Hyaluronidase Enzyme: This component works directly on fibrous tissue, helping to break down fibrosis and reduce excessive connective tissue.
2. High-Molecular Carrier: This carrier has anti-inflammatory properties, allowing the safe use of the medication during acute phases of inflammation.

This unique combination significantly improves the stability of the enzyme, prolonging its therapeutic action for better results.

What Are the Applications of Longidaza®?

Longidaza® has diverse applications across several medical specialties, such as:

• Gynecology: Used for the prevention and treatment of pelvic adhesions, management of chronic inflammatory diseases of the reproductive organs, tubal-peritoneal infertility, and aiding post-surgical recovery.
• Urology: Treats chronic prostatitis, Peyronie’s disease, early-stage benign prostatic hyperplasia, and prevents the formation of scars following procedures on the urinary tract.
• Dermatology and Venereology: Suitable for conditions like limited scleroderma and in preventing fibrotic complications from sexually transmitted infections.
• Pulmonology and Phthisiology: Manages pulmonary fibrosis, certain types of tuberculosis, and other chronic lung conditions.
• Surgical Applications: Supports post-operative recovery by preventing adhesions and promoting the healing of long-lasting wounds.

How Should Longidaza® Be Used?

Recommended Dosage and Administration:

Longidaza® is administered rectally or vaginally, typically in the evening:

• Rectal Use: Insert one suppository once daily after bowel evacuation.
• Vaginal Use: Insert one suppository at bedtime in a lying-down position.

The specific dosage and treatment duration may vary by condition:

• Urology: Generally, one suppository is used every other day, totaling 20 doses.
• Gynecology: A regimen of one suppository every two days for 10 doses is common, with optional maintenance therapy as needed.
• Pulmonology: Doses may be administered every 2-4 days, with total courses ranging from 10 to 20 doses based on the severity.

What Are the Contraindications and Precautions?

Before beginning Longidaza® therapy, certain contraindications should be noted:

• Allergy Concerns: Avoid use if there is a known hypersensitivity to hyaluronidase or other ingredients in the formulation.
• Acute Medical Conditions: Conditions such as lung bleeding, recent eye hemorrhages, and acute renal failure are contraindications for use.
• Specific Populations: Longidaza® is not recommended for children under 18, pregnant women, or patients with certain kidney conditions. For those with chronic kidney disease, the frequency should be reduced and monitored closely.

Can Longidaza® Be Combined with Other Medications?

Longidaza® can be safely used alongside antibiotics, antifungal treatments, bronchodilators, and similar medications.

However, it is advised not to use it with certain medications like furosemide, benzodiazepines, phenytoin, or adrenaline to avoid reducing enzyme effectiveness.

Are There Any Side Effects?

Side effects are rare but may include local reactions such as redness, swelling, or itching at the application site.

If any of these symptoms occur, it’s recommended to discontinue use and seek medical advice.

How Should Longidaza® Be Stored?

• Shelf Life: 2 years from the manufacturing date.
• Storage Conditions: Keep below 15 °C (59 °F) and do not freeze. Ensure it is out of children’s reach.