Lioton 1000 100g gel (topical application)
- $38.70
The instruction for medical use
of Lioton medicine 1000 gel
the Trade name
Lioton gel
the International unlicensed
name Heparin Sodium Dosage Form Gel Structure
of 100 g of gel contains 1000
active agent - ME heparin sodium 100,000,
excipients: ethanol, carbomer 940, trolamin, methylparahydroxybenzoate, propilparagidroksibenzoat, oil of wild orange flowers (neroli oil), oil lavender, the water purified.
The description
Almost transparent gel, colourless or slightly yellowish color, viscous consistence, with a fragrant smell
the Pharmacotherapeutic
Treatment of a Syndrome of a Varicosity group. Geparinsoderzhashchy drugs for topical administration
the Code of automatic telephone exchange C05B A03
the Pharmacological
Pharmacokinetics In properties pharmacokinetics researches on animals it is established that heparin sodium is soaked up in blood at topical administration, its content in blood reaches the maximum level 8 hours later after use and in 12-24 hours returns to norm then heparin sodium is removed, mainly, with urine.
At external use Lioton gel did not cause 1000 changes of indicators of a coagulant system of blood of the person.
The pharmacodynamics
Lioton gel is 1000 anticoagulant of direct action. Besides well-known anti-coagulative properties, heparin and heparinoids can have anti-inflammatory effect, suppress development of the hyperpermeability of walls of vessels caused by a histamine, bradykinin and E1 prostaglandin, to reduce pains, to interfere with education and further growth of blood clots and also to promote their resorption. Thus, Lioton the gel entered in the transdermal way renders 1000 antiedematous, antigranulomatozny, anti-exudative, anti-inflammatory and antitrombotichesky action.
Indications
- treatment of diseases of superficial veins: a varicosity, a lymphangitis, a phlebothrombosis, phlebitis, thrombophlebitis, a superficial periphlebitis, post-injection phlebitis
- injuries and bruises (an injury and stretching of musculotendinous and capsular and copular structures), infiltrates and the localized hypostases, hypodermic hematomas
the Route of administration and doses
the Adult outwardly: from one to three times a day. 3 - 10 cm (0.5-1g) of a column of gel apply on an affected area of skin and carefully rub.
Side effects
Shipping - as local, and the general - very good.
Seldom
- allergic reactions to heparin in the form of erubescence and an itching which quickly disappear after
Contraindication drug phase-out
- sensitivity to heparin or to any other component of drug including on parabens
- children's and teenage age up to 18 years
Medicinal interactions
Use of heparin can promote lengthening of a prothrombin time at the patients accepting oral anticoagulants.
Do not appoint locally along with non-steroidal anti-inflammatory drugs, tetracyclines and antihistaminic drugs. Nevertheless, interaction with other medicines at topical administration was not observed what, however it is impossible to exclude in case of prolonged use.
Special instructions
in the presence of hemorrhages it is necessary to weigh carefully a question of use of drug Lioton 1000 gel.
Lioton gel it is not necessary to apply 1000 in bleedings, to apply on open wound surfaces or on mucous membranes and also on the infected sites in the presence of purulent processes.
Liotona of 1000 gel contains in quality of excipients methyl-p-hydroxybenzoate and propyl-p-hydroxybenzoate therefore it cannot be applied at patients with an allergy to parabens.
Use in pediatrics
Because of limited experience of use of drug for children and for the reason that there is an insufficient number of these researches, it is not necessary to use this drug at treatment of children.
Pregnancy and the period of a lactation
of Specific data on use of drug during pregnancy and during feeding by a breast is not available.
Heparin does not break a placental barrier and is not removed with maternal milk. Unambiguous data that at topical administration heparin contributes to the development of congenital defects are not available. During breastfeeding Lioton gel should not be applied on area of a breast. During pregnancy and feeding by a breast heparin has to be applied only in emergency cases, after careful assessment of a ratio of advantage to mother and risk to a fruit.
Features of influence of medicine on ability to run the vehicle and potentially dangerous mekhnaizm
Lioton gel does not affect 1000 reactionary ability therefore the negative impact on ability to driving of the vehicle and to service of cars is not rendered
by Overdose
Still cases of overdose are not described. At topical administration the overdose is improbable. At accidental ingestion of gel, systemic side effects which expressiveness depends on amount of the drug taken inside can develop. The heparin accepted inside is not soaked up. Nevertheless, in case of overdose the treatment has to have the symptomatic, supporting character.
The form of release and packing
On 30, 50 and 100 g of drug place in an aluminum tuba.
On 1 tuba together with the instruction for use in the state and Russian languages place in a cardboard pack.
To Store storage conditions at a temperature not over 25 of C
to Store out of children's reach!
The period of storage
of 5 years
After expiry date medicine cannot be used.
Prescription status
Without prescription
the Producer A. Menarini Manyufekchering Logistics and Services of Neuter of l., Italy
the Owner of the registration certificate
A. Menarini Industrie Pharmacheutike Riunite of Neuter of l., Italy
the Authorized representative
BERLIN-HEMI AG (MENARINI GROUP) Glinniker Weg 125 12489 of Berlin, Germany
the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods):
Representative office of joint-stock company Berlin-Hemi AG in RK
Phone number: +77272446183, 2446184, 2446185
fax number: +7 727 2446180
the e-mail address: Kazakhstan@berlin-chemie.com
of Lioton medicine 1000 gel
the Trade name
Lioton gel
the International unlicensed
name Heparin Sodium Dosage Form Gel Structure
of 100 g of gel contains 1000
active agent - ME heparin sodium 100,000,
excipients: ethanol, carbomer 940, trolamin, methylparahydroxybenzoate, propilparagidroksibenzoat, oil of wild orange flowers (neroli oil), oil lavender, the water purified.
The description
Almost transparent gel, colourless or slightly yellowish color, viscous consistence, with a fragrant smell
the Pharmacotherapeutic
Treatment of a Syndrome of a Varicosity group. Geparinsoderzhashchy drugs for topical administration
the Code of automatic telephone exchange C05B A03
the Pharmacological
Pharmacokinetics In properties pharmacokinetics researches on animals it is established that heparin sodium is soaked up in blood at topical administration, its content in blood reaches the maximum level 8 hours later after use and in 12-24 hours returns to norm then heparin sodium is removed, mainly, with urine.
At external use Lioton gel did not cause 1000 changes of indicators of a coagulant system of blood of the person.
The pharmacodynamics
Lioton gel is 1000 anticoagulant of direct action. Besides well-known anti-coagulative properties, heparin and heparinoids can have anti-inflammatory effect, suppress development of the hyperpermeability of walls of vessels caused by a histamine, bradykinin and E1 prostaglandin, to reduce pains, to interfere with education and further growth of blood clots and also to promote their resorption. Thus, Lioton the gel entered in the transdermal way renders 1000 antiedematous, antigranulomatozny, anti-exudative, anti-inflammatory and antitrombotichesky action.
Indications
- treatment of diseases of superficial veins: a varicosity, a lymphangitis, a phlebothrombosis, phlebitis, thrombophlebitis, a superficial periphlebitis, post-injection phlebitis
- injuries and bruises (an injury and stretching of musculotendinous and capsular and copular structures), infiltrates and the localized hypostases, hypodermic hematomas
the Route of administration and doses
the Adult outwardly: from one to three times a day. 3 - 10 cm (0.5-1g) of a column of gel apply on an affected area of skin and carefully rub.
Side effects
Shipping - as local, and the general - very good.
Seldom
- allergic reactions to heparin in the form of erubescence and an itching which quickly disappear after
Contraindication drug phase-out
- sensitivity to heparin or to any other component of drug including on parabens
- children's and teenage age up to 18 years
Medicinal interactions
Use of heparin can promote lengthening of a prothrombin time at the patients accepting oral anticoagulants.
Do not appoint locally along with non-steroidal anti-inflammatory drugs, tetracyclines and antihistaminic drugs. Nevertheless, interaction with other medicines at topical administration was not observed what, however it is impossible to exclude in case of prolonged use.
Special instructions
in the presence of hemorrhages it is necessary to weigh carefully a question of use of drug Lioton 1000 gel.
Lioton gel it is not necessary to apply 1000 in bleedings, to apply on open wound surfaces or on mucous membranes and also on the infected sites in the presence of purulent processes.
Liotona of 1000 gel contains in quality of excipients methyl-p-hydroxybenzoate and propyl-p-hydroxybenzoate therefore it cannot be applied at patients with an allergy to parabens.
Use in pediatrics
Because of limited experience of use of drug for children and for the reason that there is an insufficient number of these researches, it is not necessary to use this drug at treatment of children.
Pregnancy and the period of a lactation
of Specific data on use of drug during pregnancy and during feeding by a breast is not available.
Heparin does not break a placental barrier and is not removed with maternal milk. Unambiguous data that at topical administration heparin contributes to the development of congenital defects are not available. During breastfeeding Lioton gel should not be applied on area of a breast. During pregnancy and feeding by a breast heparin has to be applied only in emergency cases, after careful assessment of a ratio of advantage to mother and risk to a fruit.
Features of influence of medicine on ability to run the vehicle and potentially dangerous mekhnaizm
Lioton gel does not affect 1000 reactionary ability therefore the negative impact on ability to driving of the vehicle and to service of cars is not rendered
by Overdose
Still cases of overdose are not described. At topical administration the overdose is improbable. At accidental ingestion of gel, systemic side effects which expressiveness depends on amount of the drug taken inside can develop. The heparin accepted inside is not soaked up. Nevertheless, in case of overdose the treatment has to have the symptomatic, supporting character.
The form of release and packing
On 30, 50 and 100 g of drug place in an aluminum tuba.
On 1 tuba together with the instruction for use in the state and Russian languages place in a cardboard pack.
To Store storage conditions at a temperature not over 25 of C
to Store out of children's reach!
The period of storage
of 5 years
After expiry date medicine cannot be used.
Prescription status
Without prescription
the Producer A. Menarini Manyufekchering Logistics and Services of Neuter of l., Italy
the Owner of the registration certificate
A. Menarini Industrie Pharmacheutike Riunite of Neuter of l., Italy
the Authorized representative
BERLIN-HEMI AG (MENARINI GROUP) Glinniker Weg 125 12489 of Berlin, Germany
the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods):
Representative office of joint-stock company Berlin-Hemi AG in RK
Phone number: +77272446183, 2446184, 2446185
fax number: +7 727 2446180
the e-mail address: Kazakhstan@berlin-chemie.com
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