The instruction for medical use
of Linex medicine forte
the Trade name
of Linex forte
the International unlicensed name
Is not present
the Dosage form
of the Structure One Capsule Capsule
mix 64 - 60.0 mg which contains contains Probio-tec AB active agent:
Lactobacillus acidophilus - 13.8 mg,
Bifidobacterium animalis subsp. lactis - 4.2 mg,
excipients: Probio-tec AB contains mix 64:
glucose anhydrous, cellulose microcrystalline, potato starch, magnesium stearate, Beneo Synergy 1 *, magnesium stearate,
body composition of the capsule: titan dioxide (E 171), hydroksipropilmetiltsellyuloza.
structure of a cover of the capsule: titan dioxide (E 171), ferrous oxide yellow (E 172), hydroksipropilmetiltsellyuloza.
The description
Solid capsules No. 2, a body of the capsule of white color, a cover of the capsule of yellow color, contents light-beige powder with yellow specks.
Pharmacotherapeutic group
Antidiarrheal drugs. Anti-diarrheal microorganisms. A combination of the microorganisms producing lactic acid with other
drugs ATX A07FA51 Code Pharmacological Pharmacokinetics Components Properties, being a part of drug, do not come to a system blood stream therefore carrying out a kinetic research in this case is not applicable. Gastric acid and bile resistance of strains of LA-5 and VV-12 allows to survive when passing through a stomach and a duodenum to bigger number of bacteria. Both strains adgezirutsya on mucous intestines. As well as all other microorganisms which are present at digestive tract they are gradually removed at the expense of a vermicular movement and during defecation.
The capsuly Linex pharmacodynamics forte contain 2 various species of the viable lyophilized lactobacilli which are a part of normal intestinal microflora and participate in creation and maintenance of balance and function of intestinal microflora.
Linex which are a part forte bifido- and lactobacilli support and regulate physiological balance of intestinal microflora (microbiocenosis) and provide its physiological functions (antimicrobic, vitamin, digestive) in all departments of intestines - from a small intestine to a straight line.
Lactobacilli meet in thin more often, and bifidobacteria - in a large intestine. Getting into intestines, components of Linex forte perform all functions of own normal intestinal microflora:
- create unfavorable conditions for reproduction and activity of pathogenic microorganisms, by development of the metabolites and bakterin toxic for pathogenic bacteriums and also by the competition to pathogenic bacteriums for nutrients and blockings of adhesive receptors that interferes with colonization of potentially pathogenic microorganisms
- participate in synthesis of B1, B2, B3, PP vitamins, folic acid, vitamins K and E, ascorbic acid (normal microflora completely provides needs of the person for B6 and H vitamins (biotin), B12 vitamin in the nature is synthesized only by microorganisms)
- producing lactic acid and reducing rn intestinal contents, create favorable conditions for absorption of iron, calcium, vitamin D
- the lactic microorganisms inhabiting a small intestine carry out zymolysis of proteins, fats and complex carbohydrates (including in a lactose intolerance at children), the proteins and carbohydrates which are not soaked up in a small intestine are exposed to deeper splitting in a large intestine anaerobe bacterias (including bifidobacteria)
- emit enzymes, facilitating proteopepsis at babies (phosphoprotein-phosphatase of bifidobacteria participates in milk casein metabolism)
- participate in metabolism of bile acids (formation of stercobilin, coprosterol, deoxycholic and lithocholic acids, promote a reabsorption of bile acids)
Indications
- for prevention and as supportive application at a disbioz (dysbacteriosis), diarrhea, an abdominal distension and other gastrointestinal disturbances which are caused by viral and bacterial infections of digestive tract in newborns, children and adults (for example, a rotavirus infection, diarrhea), antimicrobial means (antibiotics and other synthetic antimicrobial means), radiation therapy of an abdominal cavity and bodies of a basin.
Babies and children up to 2 years are recommended to accept a route of administration and doses on 1 capsule during meal once a day, washing down with a small amount of liquid.
If the child cannot swallow the capsule, it is possible to open and mix it contents with a small amount of liquid - tea, juice, the sugared water. It does not affect viability of the bacteria which are a part of drug.
It is recommended to children from 2 to 12 years 1 - 2 time a day on 1 capsule during meal, washing down with a small amount of liquid.
If the child cannot swallow the whole capsule, contents with a small amount of liquid are allowed to open and mix it.
To adults and children 12 years are more senior it is recommended 1 - 3 time a day on 1 capsule during meal, washing down with a small amount of liquid.
Duration of treatment depends on the reason of development of dysbacteriosis and specific features of an organism.
If the condition of the patient after two days of treatment of Linex forte does not improve, it is necessary to see a doctor.
Side effects
Very seldom:
- allergic reactions
of the Contraindication
- hypersensitivity (intolerance) to any of components of drug or dairy products
- hereditary intolerance of fructose, deficiency of Lapp-lactoses enzyme, glucose galactose malabsorption
Medicinal interactions
of the Research of medicinal interaction were not carried out.
As well as other bacteria, lactobacilli are susceptible to antibiotics. For this reason it is recommended to accept capsules of Linex forte not earlier than in 3 hours after reception of antibiotics.
Special instructions
should not be washed down drug with hot drinks and to accept along with alcohol.
Treatment of diarrhea at children is younger than 6 years carry out under observation of the doctor.
During treatment of diarrhea it is very important to compensate loss of liquid and electrolytes.
Linex forte contains anhydrous glucose and oligofructose, in this regard patients with rare hereditary problems of intolerance of fructose, deficiency of sucrose - isomaltoses, glucose absorption disturbances - galactoses should not take the drug.
Drug contains residues of milk proteins which can provoke allergic reaction.
Before therapy the patient should consult with the doctor in the following cases:
- if body temperature exceeds 38 C
- if at a chair there is blood or slime
- if diarrhea proceeds more than two days
- if diarrhea has plentiful character and is followed by dehydration and loss of body weight
- if diarrhea is followed by severe pains in a stomach
- to the patients having such chronic diseases as: diabetes, cardiovascular diseases, immunodeficiency (for example, HIV infection).
Pregnancy and a lactation
Use in diarrhea during pregnancy and a lactation has to be carried out under the supervision of the doctor.
As data on safety of use of the drug Linex forte during pregnancy and a lactation are not enough, its use during the specified periods is not recommended.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
of the Research about influence of drug on ability to run the vehicle or potentially dangerous mechanisms were not carried out.
The overdose
is not revealed
the Form of release and packing
On 7 capsules place in blister strip packaging from aluminum foil.
On 2 or 4 blister strip packagings together with the instruction for medical use in the state and Russian languages place in a pack from cardboard.
To Store storage conditions at a temperature not higher than 25 wasps.
To store out of children's reach!
2 years
not to apply a period of storage after the expiry date specified on packing.
Prescription status
Without prescription
the Producer/packer Lek of of, Kolodvorsk of tsest 27, Menges, Slovenia
the Owner of the registration certificate
Lek Pharmasyyutikals of of of Verovshkov 57, Ljubljana, Slovenia
the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods)
Representative office of JSC Sandoz Pharmasyyutikals of of in Republic of Kazakhstan, Almaty, Luganskogo St. 96
ph. +7 (727) 2581048 Fax: +7 (727) 2581047
e-mail:
To Develop kzsdz.drugsafety@sandoz.com
of Linex medicine forte
the Trade name
of Linex forte
the International unlicensed name
Is not present
the Dosage form
of the Structure One Capsule Capsule
mix 64 - 60.0 mg which contains contains Probio-tec AB active agent:
Lactobacillus acidophilus - 13.8 mg,
Bifidobacterium animalis subsp. lactis - 4.2 mg,
excipients: Probio-tec AB contains mix 64:
glucose anhydrous, cellulose microcrystalline, potato starch, magnesium stearate, Beneo Synergy 1 *, magnesium stearate,
body composition of the capsule: titan dioxide (E 171), hydroksipropilmetiltsellyuloza.
structure of a cover of the capsule: titan dioxide (E 171), ferrous oxide yellow (E 172), hydroksipropilmetiltsellyuloza.
The description
Solid capsules No. 2, a body of the capsule of white color, a cover of the capsule of yellow color, contents light-beige powder with yellow specks.
Pharmacotherapeutic group
Antidiarrheal drugs. Anti-diarrheal microorganisms. A combination of the microorganisms producing lactic acid with other
drugs ATX A07FA51 Code Pharmacological Pharmacokinetics Components Properties, being a part of drug, do not come to a system blood stream therefore carrying out a kinetic research in this case is not applicable. Gastric acid and bile resistance of strains of LA-5 and VV-12 allows to survive when passing through a stomach and a duodenum to bigger number of bacteria. Both strains adgezirutsya on mucous intestines. As well as all other microorganisms which are present at digestive tract they are gradually removed at the expense of a vermicular movement and during defecation.
The capsuly Linex pharmacodynamics forte contain 2 various species of the viable lyophilized lactobacilli which are a part of normal intestinal microflora and participate in creation and maintenance of balance and function of intestinal microflora.
Linex which are a part forte bifido- and lactobacilli support and regulate physiological balance of intestinal microflora (microbiocenosis) and provide its physiological functions (antimicrobic, vitamin, digestive) in all departments of intestines - from a small intestine to a straight line.
Lactobacilli meet in thin more often, and bifidobacteria - in a large intestine. Getting into intestines, components of Linex forte perform all functions of own normal intestinal microflora:
- create unfavorable conditions for reproduction and activity of pathogenic microorganisms, by development of the metabolites and bakterin toxic for pathogenic bacteriums and also by the competition to pathogenic bacteriums for nutrients and blockings of adhesive receptors that interferes with colonization of potentially pathogenic microorganisms
- participate in synthesis of B1, B2, B3, PP vitamins, folic acid, vitamins K and E, ascorbic acid (normal microflora completely provides needs of the person for B6 and H vitamins (biotin), B12 vitamin in the nature is synthesized only by microorganisms)
- producing lactic acid and reducing rn intestinal contents, create favorable conditions for absorption of iron, calcium, vitamin D
- the lactic microorganisms inhabiting a small intestine carry out zymolysis of proteins, fats and complex carbohydrates (including in a lactose intolerance at children), the proteins and carbohydrates which are not soaked up in a small intestine are exposed to deeper splitting in a large intestine anaerobe bacterias (including bifidobacteria)
- emit enzymes, facilitating proteopepsis at babies (phosphoprotein-phosphatase of bifidobacteria participates in milk casein metabolism)
- participate in metabolism of bile acids (formation of stercobilin, coprosterol, deoxycholic and lithocholic acids, promote a reabsorption of bile acids)
Indications
- for prevention and as supportive application at a disbioz (dysbacteriosis), diarrhea, an abdominal distension and other gastrointestinal disturbances which are caused by viral and bacterial infections of digestive tract in newborns, children and adults (for example, a rotavirus infection, diarrhea), antimicrobial means (antibiotics and other synthetic antimicrobial means), radiation therapy of an abdominal cavity and bodies of a basin.
Babies and children up to 2 years are recommended to accept a route of administration and doses on 1 capsule during meal once a day, washing down with a small amount of liquid.
If the child cannot swallow the capsule, it is possible to open and mix it contents with a small amount of liquid - tea, juice, the sugared water. It does not affect viability of the bacteria which are a part of drug.
It is recommended to children from 2 to 12 years 1 - 2 time a day on 1 capsule during meal, washing down with a small amount of liquid.
If the child cannot swallow the whole capsule, contents with a small amount of liquid are allowed to open and mix it.
To adults and children 12 years are more senior it is recommended 1 - 3 time a day on 1 capsule during meal, washing down with a small amount of liquid.
Duration of treatment depends on the reason of development of dysbacteriosis and specific features of an organism.
If the condition of the patient after two days of treatment of Linex forte does not improve, it is necessary to see a doctor.
Side effects
Very seldom:
- allergic reactions
of the Contraindication
- hypersensitivity (intolerance) to any of components of drug or dairy products
- hereditary intolerance of fructose, deficiency of Lapp-lactoses enzyme, glucose galactose malabsorption
Medicinal interactions
of the Research of medicinal interaction were not carried out.
As well as other bacteria, lactobacilli are susceptible to antibiotics. For this reason it is recommended to accept capsules of Linex forte not earlier than in 3 hours after reception of antibiotics.
Special instructions
should not be washed down drug with hot drinks and to accept along with alcohol.
Treatment of diarrhea at children is younger than 6 years carry out under observation of the doctor.
During treatment of diarrhea it is very important to compensate loss of liquid and electrolytes.
Linex forte contains anhydrous glucose and oligofructose, in this regard patients with rare hereditary problems of intolerance of fructose, deficiency of sucrose - isomaltoses, glucose absorption disturbances - galactoses should not take the drug.
Drug contains residues of milk proteins which can provoke allergic reaction.
Before therapy the patient should consult with the doctor in the following cases:
- if body temperature exceeds 38 C
- if at a chair there is blood or slime
- if diarrhea proceeds more than two days
- if diarrhea has plentiful character and is followed by dehydration and loss of body weight
- if diarrhea is followed by severe pains in a stomach
- to the patients having such chronic diseases as: diabetes, cardiovascular diseases, immunodeficiency (for example, HIV infection).
Pregnancy and a lactation
Use in diarrhea during pregnancy and a lactation has to be carried out under the supervision of the doctor.
As data on safety of use of the drug Linex forte during pregnancy and a lactation are not enough, its use during the specified periods is not recommended.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
of the Research about influence of drug on ability to run the vehicle or potentially dangerous mechanisms were not carried out.
The overdose
is not revealed
the Form of release and packing
On 7 capsules place in blister strip packaging from aluminum foil.
On 2 or 4 blister strip packagings together with the instruction for medical use in the state and Russian languages place in a pack from cardboard.
To Store storage conditions at a temperature not higher than 25 wasps.
To store out of children's reach!
2 years
not to apply a period of storage after the expiry date specified on packing.
Prescription status
Without prescription
the Producer/packer Lek of of, Kolodvorsk of tsest 27, Menges, Slovenia
the Owner of the registration certificate
Lek Pharmasyyutikals of of of Verovshkov 57, Ljubljana, Slovenia
the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods)
Representative office of JSC Sandoz Pharmasyyutikals of of in Republic of Kazakhstan, Almaty, Luganskogo St. 96
ph. +7 (727) 2581048 Fax: +7 (727) 2581047
e-mail:
To Develop kzsdz.drugsafety@sandoz.com
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