Hydrocortisone Ointment 1%, 10 g tube
- $5.00
Compound
100 g of ointment contains
- Active ingredient: Hydrocortisone acetate - 1.0 g,
- Excipients: methyl parahydroxybenzoate (nipagin), propyl parahydroxybenzoate (nipazole), petrolatum, stearic acid, anhydrous lanolin, pentaerythrityl dioleate (pentol), purified water.
Pharmacological properties
Pharmacokinetics
After application, it accumulates in the epidermis (mainly in the granular layer). It is metabolized directly in the epidermis, and later in the liver. Metabolites and a small part of unchanged hydrocortisone are excreted in the urine or bile.
Pharmacodynamics
Hydrocortisone is a synthetic glucocorticoid drug for topical use. It has anti-inflammatory, anti-edematous, antipruritic effect. It inhibits the release of cytokines (interleukins and interferon) from lymphocytes and macrophages, inhibits the release of inflammatory mediators by eosinophils, reduces the metabolism of arachidonic acid and the synthesis of prostaglandins. By stimulating steroid receptors, it induces the formation of a special class of proteins - lipocortins, which have anti-edematous activity. Reduces inflammatory cell infiltrates, reduces the migration of leukocytes and lymphocytes to the area of inflammation. Topical application of the drug in recommended doses does not cause systemic side effects.
Indications for use
Inflammatory and allergic skin diseases of non-microbial etiology:
- eczema
- allergic and contact dermatitis
- neurodermatitis
- psoriasis
Dosage and administration
locally. The ointment is applied in a thin layer to the affected areas of the skin 2-3 times a day. The duration of the course of treatment depends on the nature of the disease and the effectiveness of therapy, usually 6-14 days; with a persistent course of the disease, it can be extended up to 20 days. On limited foci, occlusive dressings can be used to enhance the effect. When using the ointment in children aged 2 years and older, the total duration of treatment should be limited and measures leading to increased resorption of steroid absorption (warming, fixing and occlusive dressings) should be excluded.
Side effects
- hyperemia
- swelling and itching in the places where the ointment is applied
With prolonged use of the ointment or the use of an occlusive dressing:
- hypercortisolism, as a manifestation of the resorptive action of hydrocortisone acetate
- secondary infectious lesions of the skin, atrophic changes in it, hypertrichosis.
Contraindications
- hypersensitivity to the drug or its other components
- wound and ulcerative lesions, bacterial, viral and fungal skin diseases
- skin tuberculosis
- syphilitic skin lesions
- rosacea, acne vulgaris
- perioral dermatitis
- post-vaccination period
- pregnancy, lactation
- skin tumors
- children's age up to 2 years.
With caution in diabetes.
Drug Interactions
To prevent infectious skin lesions, the drug is recommended to be prescribed in combination with antibacterial and antifungal agents.
Special instructions
Application in pediatrics
In cases of using the drug in children, on the face area, the duration of the course of treatment should be reduced.
In childhood, adrenal suppression may develop more rapidly. In addition, there may be a decrease in the excretion of growth hormone. When using the drug for a long time, it is necessary to monitor body weight, height, plasma cortisol levels.
Avoid getting the ointment in the eyes. For children under 12 years of age, the drug is prescribed only under strict medical supervision. If after 7 days of use there is no improvement or worsening of the condition, as well as in the case of resumption of symptoms a few days after discontinuation of the drug, the use of the drug should be discontinued and a doctor should be consulted. For long-term treatment and/or application to large surfaces, it is recommended to prescribe a sodium-restricted diet with a high content of K +; get enough protein into your body.
To prevent infectious skin lesions, the drug is recommended to be prescribed in combination with antibacterial and antifungal agents.
It is necessary to control blood pressure, blood glucose, blood clotting, diuresis, body weight of the patient, plasma cortisol levels.
Features of the influence of the drug on the ability to drive a vehicle or potentially dangerous mechanisms
Does not affect
Overdose
Symptoms: with prolonged use of the drug in large doses, symptoms of hypercortisolism may appear.
Treatment: drug withdrawal. Symptomatic therapy.
Storage conditions
Store at a temperature not exceeding 15 ºС.
Keep out of the reach of children!
Shelf life - 3 years
Do not use after the expiration date.
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