The instruction for use Hondrotek Forte of dietary supplement to food is not the medicine Structure 1 capsule contains: glycosamine dipotassium sulfate chloride of 500 mg essential phospholipids of 100 mg ascorbic acid of 2 mg of chondroitin sodium sulfate of 150 mg vitamin E (tocopherol alpha acetate) BF (50%) 50 ME magnesium aluminosilicate hydrate of 5 mg bottled hydroxytoluene of 1 mg talc of 12 mg solid gelatin capsules 00 size, white/white Nutrition value: proteins - 12.9 g / 100 g, fats - 0.3 g / 100 g, carbohydrates – 12.06 g / 100 g. Energy value: 103 kcal (432 kJ) of/100 g. The combined product regulating exchange in cartilaginous tissue. A glycosamine sulfate and chondroitin sulfate take part in biosynthesis of connective tissue, promote prevention of processes of destruction of a cartilage and oppression of persistent inflammation in joint tissues. Introduction of an exogenous glycosamine strengthens development of a cartilaginous matrix and provides nonspecific protection of a cartilage against chemical damage. The glycosamine in the form of sulphatic salt is for cartilage joints a predecessor a hexosemine, and sulfate-anion is necessary for synthesis of glikozaminoglikan. Other function of a glycosamine is protection of the injured cartilage against the metabolic destruction caused by NPVS and state treasury bills and also anti-inflammatory action. A glycosamine sulfate suppresses formation of superoxidic radicals, possesses the structural modifying action, suppresses catabolic processes (tsitokinzavisimy destruction of a cartilage), stimulates anabolic processes (proteoglycan synthesis). A glycosamine sulfate slows down apoptosis of chondrocytes, suppresses nitrogen oxide synthesis that explains analgetic effect. N - acetyl - D - a glycosamine reduces inflammation. Chondroitin the sulfate (received from cartilages of a shark) irrespective of whether it is soaked up in an intact form or in the form of separate components, is additional substrate for formation of a cartilaginous matrix. Chondroitin sulfate and its derivatives stimulate formation of hyaluronic acid, synthesis of proteoglycans and collagen II of type and also protect hyaluronic acid from zymolysis (by suppression of activity of hyaluronidase) and from the damaging action of free radicals. Chondroitin sulfate maintains viscosity of synovial fluid, stimulates mechanisms of a reparation of a cartilage and suppresses activity of enzymes (elastase, hyaluronidase) which split a cartilage. Being the viscous, hydrated polyanion, it interferes with compression of connective tissue and plays a role of a peculiar lubricant of articulate surfaces. Promotes improvement of physical activity of the affected joints. Sulfate chondroitin use at early stages of diseases of joints leads to delay of processes of destruction of cartilaginous tissue that in turn leads to reduction of painful process, and allows to lower a dosage of the accepted NPVS considerably. Vitamins E and With – the antioxidants preventing the inflammation and damages caused by free radicals. The essential phospholipids which are a part of drug, being structural units of all cellular membranes, restore structure, barrier and exchange functions of cells of bones and a cartilage. Besides, essential phospholipids promote synthesis of a glycosamine of sulfate in an organism. The scope of Hondrotek® of Forte is an additional source of essential phospholipids, vitamin C and vitamin E. At regular use promotes: - to improvement of a functional condition of a bone and articulate system (reduction of joint pains, improvement of mobility and flexibility of joints) - stimulations of mechanisms of a reparation of cartilaginous tissue. Patients with body weight it is less than 60 kg of recommendation about use: on 1 capsule 3 times a day in 1.5 hours prior to food. Patients with body weight it is higher than 60 kg: on 2 capsules 3 times a day in 1.5 hours prior to food. If within 2 weeks after the beginning of reception of Hondrotek® of Forte there is no significant improvement, to the above-stated dosage add 1 additional capsule on each reception. For example, for the patient weighing over 60 kg the dosage will make 3 capsules 3 times a day. Contraindications Hypersensitivity to product components. To Store storage conditions at a temperature not over 25 ºС. To store out of children's reach! 3 years not to use a period of storage after the expiry date specified on packing. A form of release and packing of the Capsule, 30 capsules with the enclosed recommendation about use in packing. Nabros Pharm Pvt. Ltd producer. Neshional Hayvey, 8 Kadzhipur, Kheda-387411, India Production license: G/1127 the Address of the organization accepting claims from consumers: TO Nizhpharm Kazakhstan LLP, Almaty, path Krasnogvardeysky, 258B Marketing and distribution of STADA CIS