CHARACTERISTIC ACTING VESHCHESTVTSELEBNY properties of a thistle spotty are used since antique times. The advantage of this plant, especially in hepatic disorders, confirmed with hundreds of scientific research, is connected with presence of Silymarinum at it (4-6% in ripe fruits) - active agent from group of flavonoids (more precisely, three close connections with the proved action protecting a liver). It is well studied, and the thistle can be put safely in one row with classical medicines. Main advantage. Silymarinum protects liver cells (hepatocytes), promoting process of a detoxication. This substance works as a barrier, regulating amount of the toxins arriving in unit of time on neutralization and thus not only exhaustion of reserves of glutathione warns (necessary for a detoxication), but can even increase (by 35%) its level. The thistle promotes also removal from an organism of any toxins, including environmental pollutants and medicines, protects a liver of the people abusing alcohol and having an abstinence syndrome. Besides, a thistle – the powerful antioxidant comparable on ability to neutralize free radicals with vitamins C and E. It also promotes updating of hepatocytes - replacement of the perishing cells young and healthy. Clinical trials of patients with hepatitis B and C showed that extract of a thistle slows down a nekrotization of a liver and its fibrous regeneration, lowers transaminases in blood. Additional advantage. The thistle protects a liver from side effect of gepatotoksichny medicines, slows down development of redness of peeling of skin in psoriasis as has anti-inflammatory properties. A thistle use in endometriosis (main cause of female infertility) as it reduces its symptoms, especially pain, recommend for prevention and treatment of cholelithiasis: it helps exile of the bile produced by a liver from a gall bladder in intestines where this secret participates in digestion of fats. Vitamins C and E are antioxidants, they neutralize in an organism free radicals - unstable atoms and connections which are formed during a metabolism and are present at the environment, but, collecting excessively, become dangerous. Free radicals are extremely aggressive: they attack surrounding molecules, starting reactions of uncontrolled oxidation, damaging an organism from within that is fraught with grave consequences. If free radicals oxidize DNA (genes), there are mutations breaking work of cells and threatening to them with cancer regeneration or death.
Lecithin (phosphatidylsincaline) - essential phospholipids. From the biological point of view lecithin belongs to group of the nutrients famous as fats. It is the most important structural component of cells of a brain (about 30%), a liver (60%), nerves (17%), a myelin. Essential phospholipids improve a functional condition of a liver. At disturbance of metabolism of a liver they provide intake of vysokoenergetichny phospholipids, ready to assimilation, which on chemical structure are ideally combined with endogenous phospholipids. Under the influence of essential phospholipids the kliniko-biochemical indicators characteristic of fat dystrophy of a liver, chronic hepatitis of various etiology, cirrhosis improve. In these diseases the detoksikatsionny function of a liver is broken and also the resistance of hepatocytes to toxic influences and function of an antioxidant system of an organism decreases. Use of essential phospholipids contributes to normalization of structurally functional integrity of cellular membranes of hepatocytes and allows to restore normal metabolism of a cell. Treatment by essential phospholipids leads to considerable improvement of biochemical indicators (serumal ALT, nuclear heating plant) and also to reduction of necrosis and inflammation. Positive dynamics of indicators (reduction of intra lobular necrosis, portal inflammation, the general improvement of health) in comparison with initial level was observed at the patients taking the drugs of essential phospholipids within a year. The activity of essential phospholipids in chronic degenerative diseases of a liver causes: • restoration and maintaining integrity of membranes of hepatocytes, • activization of membrane fosfolipidzavisimy enzymes, • improvement of metabolism of lipids during synthesis of lipoproteins in a liver, • RNA synthesis activation, normalization of metabolism of proteins, • increase in maintenance of a glycogen in a liver, • increase in detoksikatsionny excretory potential (detoksikatsionny function of a liver), • transformation of neutral fats and cholesterol to easily metabolized forms, • decrease in level of a metabolic cost of a liver, • reduction and disappearance of fat infiltration of hepatocytes, • antifibrotichesky effects (reduction of risk of developing fibrosis and cirrhosis), • stabilization of physical and chemical properties of bile. Biopotential of essential phospholipids is implemented not only in digestive system. There are many bases to believe that essential phospholipids: modify a course of metabolic processes, reduce atherosclerotic defeats of vessels (normalize the maintenance of lipoproteins, reduce the increased level of lipids in blood, provide mobilization of cholesterol and its removal from walls of arteries in atherosclerosis), positively influence indicators of peroxide oxidation of lipids at patients with coronary heart disease, reduce expressiveness of clinical manifestations in diabetes, improve rheological properties of blood. Oxidation of cholesterol stimulates its sticking to walls of arteries in blood and growth of atherosclerotic plaques that threatens with coronary heart disease and a stroke. The surplus of free radicals contributes to a cataract, an immunodeficiency, arthritis and the accelerated aging of an organism in general.
Glutathione - the protein playing an important role in a cellular detoxication. One of the major antioxidants which are present at an organism he acts as the virus killer in each cell. At various failures in an organism the producing glutathione is broken, its deficit leads to disturbances of brain activity (one of the fundamental causes of autism) and also (owing to mutagen processes at the cellular level) to oncological diseases. Most of all glutathione in a liver (some of its quantity is released directly in a blood stream) and also in lungs and digestive tract. It is necessary for carbohydrate metabolism, slows down aging - due to influence on lipidic exchange and prevention of developing of atherosclerosis. The deficiency of glutathione first of all affects nervous system, causing lacks of coordination, thought processes, a tremor. The amount of glutathione in an organism decreases with age therefore elderly people have to receive it in addition.
PHARMACOLOGICAL SVOYSTVAGEPA Forte has the significant gepatozashchitny effect: suppresses increase of indicator enzymes, slows down processes of a cytolysis, interferes with development of a cholestasia. At patients with diffusion damages of a liver, including alcoholic genesis, normalizes functional and morphological indicators of a gepatobiliarny system, clinical indicators. Shows antioxidant and radio tire-tread properties, strengthens detoksitsiruyushchy and vneshnesekretorny functions of a liver, has spasmolytic and anti-inflammatory effect. The MECHANISM of ACTION
Gepa Forte slows down penetration of toxins into liver cells and also causes physical and chemical stabilization of a cellular membrane of hepatocytes, preventing thereby an exit from a cell of enzymes and other substances. One of the general pathogenetic links of negative impact of various etiological factors (toxic substances, alcohol, drugs, viruses) causing chronic pathology of a liver is strengthening of processes of peroxide oxidation of lipids. At the same time a large number of free radicals who react with unsaturated fatty acids, proteins, enzymes, the involving initial molecular changes in cells is formed. Damage of membranes of hepatocytes, infiltration of portal paths, hypostasis of sinusoid results that leads to disturbance of intra hepatic circulation and a circulator hypoxia. The antioxidant effect of a gepabiol is caused by interaction of Silymarinum, vitamins C, E and glutathione with free radicals in a liver and their transformation to less toxic connections. Thanks to it process of peroxide oxidation of lipids is interrupted and there is no further destruction of cellular structures. Gepa Forte accelerates regeneration of cells of a liver due to activation of a RNA polymerase.
Use: on 1 capsule 2 times a day, before food. The latest news Perhaps, the thistle protects from a carcinoma cutaneum. In experiments on mice the American scientists from the Clevelend university in Ohio showed that the risk of formation of malignant epidermal tumors as a result of radiation by cancerogenic doses of ultraviolet when greasing animals Silymarinum decreases by 75%. Silymarinum is so effective that its injections sometimes apply in the resuscitation purposes to protection of a liver in acute poisonings with poisonous mushrooms.
To develop
Lecithin (phosphatidylsincaline) - essential phospholipids. From the biological point of view lecithin belongs to group of the nutrients famous as fats. It is the most important structural component of cells of a brain (about 30%), a liver (60%), nerves (17%), a myelin. Essential phospholipids improve a functional condition of a liver. At disturbance of metabolism of a liver they provide intake of vysokoenergetichny phospholipids, ready to assimilation, which on chemical structure are ideally combined with endogenous phospholipids. Under the influence of essential phospholipids the kliniko-biochemical indicators characteristic of fat dystrophy of a liver, chronic hepatitis of various etiology, cirrhosis improve. In these diseases the detoksikatsionny function of a liver is broken and also the resistance of hepatocytes to toxic influences and function of an antioxidant system of an organism decreases. Use of essential phospholipids contributes to normalization of structurally functional integrity of cellular membranes of hepatocytes and allows to restore normal metabolism of a cell. Treatment by essential phospholipids leads to considerable improvement of biochemical indicators (serumal ALT, nuclear heating plant) and also to reduction of necrosis and inflammation. Positive dynamics of indicators (reduction of intra lobular necrosis, portal inflammation, the general improvement of health) in comparison with initial level was observed at the patients taking the drugs of essential phospholipids within a year. The activity of essential phospholipids in chronic degenerative diseases of a liver causes: • restoration and maintaining integrity of membranes of hepatocytes, • activization of membrane fosfolipidzavisimy enzymes, • improvement of metabolism of lipids during synthesis of lipoproteins in a liver, • RNA synthesis activation, normalization of metabolism of proteins, • increase in maintenance of a glycogen in a liver, • increase in detoksikatsionny excretory potential (detoksikatsionny function of a liver), • transformation of neutral fats and cholesterol to easily metabolized forms, • decrease in level of a metabolic cost of a liver, • reduction and disappearance of fat infiltration of hepatocytes, • antifibrotichesky effects (reduction of risk of developing fibrosis and cirrhosis), • stabilization of physical and chemical properties of bile. Biopotential of essential phospholipids is implemented not only in digestive system. There are many bases to believe that essential phospholipids: modify a course of metabolic processes, reduce atherosclerotic defeats of vessels (normalize the maintenance of lipoproteins, reduce the increased level of lipids in blood, provide mobilization of cholesterol and its removal from walls of arteries in atherosclerosis), positively influence indicators of peroxide oxidation of lipids at patients with coronary heart disease, reduce expressiveness of clinical manifestations in diabetes, improve rheological properties of blood. Oxidation of cholesterol stimulates its sticking to walls of arteries in blood and growth of atherosclerotic plaques that threatens with coronary heart disease and a stroke. The surplus of free radicals contributes to a cataract, an immunodeficiency, arthritis and the accelerated aging of an organism in general.
Glutathione - the protein playing an important role in a cellular detoxication. One of the major antioxidants which are present at an organism he acts as the virus killer in each cell. At various failures in an organism the producing glutathione is broken, its deficit leads to disturbances of brain activity (one of the fundamental causes of autism) and also (owing to mutagen processes at the cellular level) to oncological diseases. Most of all glutathione in a liver (some of its quantity is released directly in a blood stream) and also in lungs and digestive tract. It is necessary for carbohydrate metabolism, slows down aging - due to influence on lipidic exchange and prevention of developing of atherosclerosis. The deficiency of glutathione first of all affects nervous system, causing lacks of coordination, thought processes, a tremor. The amount of glutathione in an organism decreases with age therefore elderly people have to receive it in addition.
PHARMACOLOGICAL SVOYSTVAGEPA Forte has the significant gepatozashchitny effect: suppresses increase of indicator enzymes, slows down processes of a cytolysis, interferes with development of a cholestasia. At patients with diffusion damages of a liver, including alcoholic genesis, normalizes functional and morphological indicators of a gepatobiliarny system, clinical indicators. Shows antioxidant and radio tire-tread properties, strengthens detoksitsiruyushchy and vneshnesekretorny functions of a liver, has spasmolytic and anti-inflammatory effect. The MECHANISM of ACTION
Gepa Forte slows down penetration of toxins into liver cells and also causes physical and chemical stabilization of a cellular membrane of hepatocytes, preventing thereby an exit from a cell of enzymes and other substances. One of the general pathogenetic links of negative impact of various etiological factors (toxic substances, alcohol, drugs, viruses) causing chronic pathology of a liver is strengthening of processes of peroxide oxidation of lipids. At the same time a large number of free radicals who react with unsaturated fatty acids, proteins, enzymes, the involving initial molecular changes in cells is formed. Damage of membranes of hepatocytes, infiltration of portal paths, hypostasis of sinusoid results that leads to disturbance of intra hepatic circulation and a circulator hypoxia. The antioxidant effect of a gepabiol is caused by interaction of Silymarinum, vitamins C, E and glutathione with free radicals in a liver and their transformation to less toxic connections. Thanks to it process of peroxide oxidation of lipids is interrupted and there is no further destruction of cellular structures. Gepa Forte accelerates regeneration of cells of a liver due to activation of a RNA polymerase.
Use: on 1 capsule 2 times a day, before food. The latest news Perhaps, the thistle protects from a carcinoma cutaneum. In experiments on mice the American scientists from the Clevelend university in Ohio showed that the risk of formation of malignant epidermal tumors as a result of radiation by cancerogenic doses of ultraviolet when greasing animals Silymarinum decreases by 75%. Silymarinum is so effective that its injections sometimes apply in the resuscitation purposes to protection of a liver in acute poisonings with poisonous mushrooms.
To develop
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