Gamalate® B6 (GB6) Syrup, 80 ml

Gamalate B6 consists of:

100 ml of the preparation contains active substances:

• Magnesium Glutamate Hydrobromide - 2.0 g


• Gamma-Aminobutyric acid (GABA) - 2.0 g


• Gamma-Amino-Beta-Hydroxybutyric acid (GABOB) - 1.0 g


• Vitamin B6 (Pyridoxine Hydrochloride) - 1.0 g

auxiliary substances: citric acid, sodium saccharin, methyl parahydroxybenzoate (E218), propyl parahydroxybenzoate (E216), raspberry essence 80374, sunset yellow FCF E110 dye, sorbitol (E420) 70%, purified water.

Pharmacological properties

Pharmacokinetics

Gamalate B6 contains four components, three of which are physiological products: γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid and pyridoxine hydrochloride (GABA, GABHMA and vitamin B6. Classical pharmacokinetic studies in this case are impossible due to the difficulty of quantifying exogenous and endogenous components.

Pharmacodynamics

The effect of the drug Gamalate B6 is due to the action of its active substances: amino acids that tone up the function of the brain, γ-aminobutyric acid and γ-amino-β-hydroxybutyric acid, a weak sedative substance - magnesium glutamate hydrobromide (MGH) and coenzyme vitamin B6.

The drug causes an increase in the energetic and neuroregulatory activity of the brain. The drug has a neuroregulatory effect on the brain. Amino acids and vitamin B6 are involved in brain metabolism and increase the energy potential of nerve cells.

Indications for use

It is prescribed as an aid for functional asthenia with manifestations:

In adults:

• Personality changes, aggressiveness, sleep disorders, agitation or anxiety, whatever the cause: school, family, work-related


• Concentration difficulties


• Emotional instability


• Nervous depression

In children:

• Poor performance at school


• Difficulties with concentration and learning


• Maladjustment to social, family and school environment

 

Mode of application

Adults: inside 10 ml 2 - 3 times a day
The duration of the course of treatment is determined by the attending physician
The minimum single dose is 10 ml
The maximum single dose is 20 ml
These doses can be changed as directed by your doctor

 

Side effects

Possible dyspeptic disorders

 

Contraindications

- hypersensitivity to drug components
- peptic ulcer of the stomach and duodenum
- severe liver damage
- coronary artery disease
- children and adolescents up to 18 years old
- pregnancy and lactation

Special instructions

Contains excipients prohibited dye yellow "sunset" E110 in children under 18 years old, sorbitol (E420) has a moderate laxative effect, methyl parahydroxybenzoate (E218) and propyl parahydroxybenzoate (E216) causes delayed-type allergic reactions.

Features of the effect of the drug on the ability to drive vehicles or other potentially dangerous mechanisms

Care should be taken when driving vehicles or other potentially dangerous machinery.

Overdose

Taking into account the low toxicity of the drug, the likelihood of poisoning is low, even if the therapeutic dose is accidentally exceeded.

Symptoms - Increased Side Effects
Treatment: Symptomatic

Storage conditions

Store at a temperature not exceeding 30C
Keep out of the reach of children!

Shelf life: 5 years
Do not use after the expiration date

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Scientific Studies

• https://pubmed.ncbi.nlm.nih.gov/32158489/


• https://juniperpublishers.com/oajnn/pdf/OAJNN.MS.ID.555696.pdf