Distreptaza® (Streptokinase + Streptodornase) 6 Rectal suppositories

What is Distreptaza®?

Distreptaza® is a rectal suppository containing a combination of streptokinase and streptodornase, both of which are enzymes used to reduce inflammation and dissolve clots.

This medication is commonly used in the treatment of pelvic inflammatory disease (PID) and other conditions related to inflammation and infection in the pelvic area.

Distreptaza® helps break down proteins and fibrin, promoting healing and reducing swelling in the affected areas.

It is also effective in managing acute and chronic hemorrhoids, perirectal abscesses, and preventing post-surgical adhesions.

Due to its specialized formulation, Distreptaza® delivers focused relief and helps accelerate recovery in individuals suffering from pelvic inflammatory conditions.

What are the indications for using Distreptaza®?

Distreptaza® is recommended for use in the following conditions:

• Pelvic Inflammatory Disease (PID): It is used in combination treatments for inflammation of the ovaries, fallopian tubes, and the uterine lining.
• Post-surgical adhesion prevention: After surgery in the pelvic area, Distreptaza® helps prevent the formation of adhesions (scar tissue).
• Hemorrhoids: It can be used for both acute and chronic hemorrhoids to relieve symptoms.
• Perirectal abscess and fistulas: It is used in combination therapies to treat abscesses and fistulas with extensive inflammation.

What precautions should be taken before using Distreptaza®?

Before using Distreptaza®, it is important to consider the following contraindications:

• Hypersensitivity to any active or inactive ingredients.
• Recent pelvic or rectal surgeries.
• Hemorrhagic diathesis (a tendency to bleed easily).
• Pregnancy and breastfeeding.
• Children and adolescents under 18 years old.
• Active inflammation of connective tissue.
• Reduced blood clotting ability.
• The medicine should not come into contact with fresh wounds or sutures, as this may cause bleeding.
• Avoid use within 10 days of any bleeding episode, as it may trigger a recurrence.
• Concurrent use with calcium salts or anticoagulants should be avoided, as it may lead to local bleeding.

What are the dosing recommendations for Distreptaza®?

The dosing regimen for Distreptaza® depends on the severity of the condition being treated:

• Severe cases: 1 suppository 3 times a day for 3 days, then 1 suppository 2 times a day for the next 3 days, and 1 suppository once daily for the following 3 days.
• Mild to moderate cases: 1 suppository 2 times a day for 3 days, followed by 1 suppository once a day for 4 days. Alternatively, 1 suppository 2 times a day for 2 days.

How should Distreptaza® be administered?

Distreptaza® is administered rectally. To use it:

1. Remove the suppository from the blister packaging.
2. Insert it deeply into the rectum.

Treatment typically lasts for 7 to 10 days, using 8 to 18 suppositories in total, depending on the condition and doctor’s instructions.

What are the possible side effects of Distreptaza®?

Though rare, some side effects may occur when using Distreptaza®:

• Local allergic reactions.
• Increased body temperature.
• Pain and swelling at the site of insertion.
• Tendency to bleed.

If any side effects are noticed, it is important to consult a healthcare provider to discuss whether to continue the treatment.

Can Distreptaza® be used during pregnancy or breastfeeding?

No, Distreptaza® should not be used during pregnancy or while breastfeeding, as it may pose risks to both the mother and child.

How should Distreptaza® be stored?

Store Distreptaza® in a cool place at a temperature between 2°C and 8°C (36°F and 46°F).

Do not freeze the product, and always keep it out of reach of children.

Ensure to check the expiration date and do not use the medication after it has expired.

What should be done in case of an overdose?

In case of an overdose, symptomatic treatment should be administered.

It is important to seek medical advice if you suspect an overdose of Distreptaza®.