ARPEFLU (Umifenovir) 100 mg, 20/30 caps

What is ARPEFLU (Umifenovir)?

ARPEFLU is an antiviral medication with Umifenovir as its active ingredient, primarily used to treat and prevent respiratory viral infections like influenza A, B, and other acute respiratory viral infections (ARVI).

It works by preventing viruses from entering and replicating within human cells by blocking the fusion of the virus with the cell membrane.

This action not only reduces the spread of infection but also stimulates the body’s immune response by enhancing interferon production and macrophage activity, which are crucial in fighting viral infections.

Other uses of Umifenovir

In addition to its role in treating influenza, Umifenovir has been investigated for its potential effectiveness against other viruses.

Some research suggests it may help combat infections like hepatitis C, West Nile virus, and other flavivirus infections.

It has also shown promise in studies for preventing entry of viruses like Ebola, hepatitis B, and poliovirus into human cells.

Furthermore, Umifenovir was explored during the COVID-19 pandemic as a possible treatment for SARS-CoV-2, though the results were mixed and did not lead to widespread adoption for this purpose​

How does ARPEFLU work?

ARPEFLU works by targeting the virus directly and preventing it from spreading within the body.

It helps the immune system recognize and attack the virus, thus reducing the symptoms of infections such as influenza A, B, and other respiratory viruses.

It also strengthens the body’s defense mechanisms, making it harder for the virus to replicate and spread.

What are the indications for using ARPEFLU?

ARPEFLU is recommended for the treatment and prevention of the following conditions:

• Influenza A and B and other acute respiratory viral infections (ARVI)
• Chronic bronchitis, pneumonia, and recurrent herpes infections as part of a combination therapy
• Prevention of viral infections during peak epidemic seasons
• Prevention of post-surgical infectious complications
• Treatment of acute intestinal infections of rotavirus origin in children over six years old

Who should avoid taking ARPEFLU?

ARPEFLU should not be used by individuals who are:

• Allergic to Umifenovir or any other ingredients in the medication
• Children under six years of age
• Pregnant or breastfeeding women (unless recommended by a healthcare professional)
• Individuals with lactose intolerance, lactase deficiency, or glucose-galactose malabsorption

What precautions should be taken while using ARPEFLU?

It is crucial to follow the prescribed dosage and treatment duration when using ARPEFLU.

If you miss a dose, take it as soon as possible and continue with your regular schedule.

If symptoms, including a high fever above 38°C (100.4°F), persist after three days of treatment, consult a healthcare professional to assess the need for further intervention.

Are there any known interactions with other medications?

ARPEFLU has not shown any negative interactions when used alongside other medications.

However, always consult with your doctor or pharmacist before combining ARPEFLU with other treatments.

Can ARPEFLU be used during pregnancy or breastfeeding?

Due to limited clinical data, ARPEFLU is not recommended for use during pregnancy or while breastfeeding unless the benefits to the mother outweigh any potential risks to the fetus or infant.

It is essential to consult a healthcare provider in such cases.

How is ARPEFLU taken?

ARPEFLU should be taken orally, either 30 minutes before or 2 hours after meals, as per the following dosage instructions:

• Children 6-12 years: 100 mg
• Adults and children over 12 years: 200 mg

For prevention:

• After exposure to an infected person: Once daily for 10-14 days
• During flu epidemics: Twice a week for three weeks

For treatment:

• Uncomplicated flu and ARVI: Four times a day for five days
• Chronic bronchitis, pneumonia, or herpes infection: Four times a day for 5-7 days, then twice a week for four weeks
• Acute intestinal rotavirus infections in children over six: Four times a day for five days

What should be done in case of overdose?

There are no reported cases of overdose with ARPEFLU.

However, if an overdose is suspected, seek medical advice immediately to ensure proper care and treatment.

What are the possible side effects of ARPEFLU?

Side effects from ARPEFLU are rare, but some individuals may experience:

• Allergic reactions such as rash or anaphylaxis
• Digestive issues, including nausea, heartburn, vomiting, or diarrhea

If any adverse reactions occur, discontinue use and consult a healthcare professional.

How should ARPEFLU be stored?

Store ARPEFLU at a temperature no higher than 25°C (77°F) and keep it out of the reach of children.

Do not use the medication after the expiration date, which is three years from the manufacturing date.