Alcoson® (Disulfiram) 500 mg, 14 tablets

What is Alcoson® (Disulfiram) 500 mg?

Alcoson® is a medication containing Disulfiram, which is commonly used to support the treatment of chronic alcoholism by discouraging the consumption of alcohol.

The primary action of Disulfiram is to induce unpleasant effects when even small amounts of alcohol are consumed, thereby deterring further drinking.

It is generally prescribed as part of a comprehensive treatment program that includes counseling and support.

How does Alcoson® work?

Alcoson® works by interfering with the normal breakdown of alcohol in the body.

When alcohol is consumed, it is converted into acetaldehyde, a toxic substance that is usually broken down further into harmless acetic acid.

Disulfiram inhibits the enzyme responsible for this conversion, leading to a buildup of acetaldehyde in the blood.

This accumulation causes a range of unpleasant symptoms, such as nausea, vomiting, headaches, and palpitations, shortly after alcohol intake.

These effects can be severe, reinforcing the patient's decision to abstain from alcohol.

What are the indications for using Alcoson®?

Alcoson® is indicated for the prevention of relapse in individuals with chronic alcoholism.

It is used as an additional therapy to help maintain abstinence from alcohol.

What precautions should be taken before using Alcoson®?

Before starting treatment with Alcoson®, it is essential to undergo a thorough medical examination.

This includes liver function tests, as Disulfiram can cause serious liver damage.

Regular monitoring of liver function is required throughout the treatment, especially during the first three months.

Patients should also be made aware of the potential for a disulfiram-alcohol reaction, which can occur even with small amounts of alcohol, including alcohol found in some medications, foods, and personal care products like aftershaves.

Who should not use Alcoson®?

Alcoson® should not be used by individuals with hypersensitivity to Disulfiram or any of its components, those with severe liver, kidney, or respiratory diseases, epilepsy, diabetes, or cardiovascular conditions. It is also contraindicated for use during pregnancy, breastfeeding, and in children under 18 years of age.

Additionally, it should not be administered to individuals who have consumed alcohol within the previous 24 hours.

What are the potential side effects of Alcoson®?

Common side effects of Alcoson® include headaches, fatigue, and drowsiness. In rare cases, it may cause polyneuropathy, confusion, memory loss, optic neuritis, and other neurological disturbances.

It can also cause gastrointestinal issues such as nausea, vomiting, and abdominal pain.

Severe liver reactions, including hepatitis, have been reported, sometimes requiring liver transplantation or leading to death.

How should Alcoson® be used?

Alcoson® is typically taken once daily with water, preferably in the morning during breakfast.

It is crucial that patients abstain from alcohol for at least 24 hours before starting treatment.

The duration of therapy is determined by a healthcare provider based on the patient’s condition.

What should be done in case of an overdose?

In the event of an overdose, Alcoson® can cause severe neurological symptoms, including confusion, coma, and encephalopathy.

Immediate medical attention is required, and treatment is symptomatic.

If an overdose occurs in combination with alcohol consumption, it can lead to serious complications such as cardiovascular collapse and neurological damage.

What storage conditions are required for Alcoson®?

Alcoson® should be stored in a dry place, protected from light, at a temperature not exceeding 25°C (77°F).

It should be kept out of reach of children.

Common brand names for Disulfiram: Esperal, Antabuse, Teturam