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Timogen 25 ug / dose 10 ml nasal spray metered


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The instruction for medical use

of medicine Thymogen the Trade name

of Thymogen Mezhdunarodnoye the unlicensed name

Is not present

the Dosage form

the Spray nasal dosed 25 mkg / a dose, 10 ml


One dose (0.1 ml) contains

active agent – alpha glutamil – tryptophane (timogen sodium in terms of timogen) 25.000 mkg,

excipients: sodium chloride, a benzalkoniya chloride, water

the Colourless transparent liquid purified the Description. Existence of a characteristic smell a chloride benzalkoniya

Pharmacotherapeutic group

Immunomodulators is allowed. Immunostimulators. Colony stimulating factors

the ATX L03AA Code

the Pharmacological

Pharmacokinetics At properties intranasal dispersion timogen is quickly and fully soaked up in blood, distributed on bodies and fabrics, being found (in decreasing order) in regional lymph nodes, a liver, kidneys, adrenal glands, a spleen, a thymus gland, in blood serum. Elimination half-life of dipeptide does not exceed 60 min. In elimination of a timogen the leading role is played by its biotransformation, to a lesser extent renal excretion. Thymogen is practically not brought with bile. Products of biotransformation of Thymogen are glutaminic acid and tryptophane of amino acid which residues form Thymogen molecule, other metabolites is not formed.

The pharmacodynamics

is the cornerstone of effect of dipeptide activization of a regulatory peptide cascade. Interacting with epimembranny cellular receptors, timogen gets into a cell and activates the systems of secondary messengers which in turn promote transition of nuclear superspiral DNA to a transcriptionally active state.

Activation of a differentiation of T lymphocytes, restoration of a ratio of immunoregulatory cells and functional activity of a system of nonspecific protection is a consequence of the processes stated above.

Drug has the normalizing impact on reactions of cell-mediated, antibody-mediated immunity and nonspecific protection of an organism, stimulates regeneration processes, restores biochemical, hematologic and coagulative indicators of blood in immunodeficiency, activates synthesis of endogenous interferon.


to Adults and children are more senior than 1 year as complex therapy and prevention:

– as a part of complex therapy of the acute and chronic infectious and inflammatory diseases which are followed by decrease in indicators of cell-mediated immunity

– for prevention of oppression of immunity, a hemopoiesis, processes of regeneration in the posttraumatic and postoperative periods in the course of performing radiation therapy or chemotherapy, when using massive doses of antibiotics

– for prevention and as a part of complex therapy of viral and bacterial, acute and chronic diseases of upper airways.

Route of administration and doses

Locally. To hold a bottle with a thumb for the basis, and a nozzle of the portioning device, between average and index fingers. To insert a nozzle of the portioning device into the nasal course in situation vertically up. To press once a nozzle.

Adult: on 1 dose in each nasal course 2 times a day within 10 days with the medical purpose or within 3-5 days with the preventive purpose.

To children: from 1 year to 6 years 1 dose in one nasal course of 1 times a day, from 7 to 14 years on 1 dose in each nasal course of 1 times a day. Drug is used within 10 days with the medical purpose or within 3-5 days with the preventive purpose.

A repeated course is conducted not earlier than in 1 month.

Take the drug only according to that route of administration and in those doses which are specified in the instruction. In case of need, please, consult with the doctor before administration of drug.

Side effects


– allergic reactions

Consult with the doctor if you showed the mentioned side effect or other side effects which are not specified in the instruction.


– hypersensitivity to a timogen

– pregnancy and the period of a lactation

– children till 1 year

Medicinal interactions

Increases efficiency of chemotherapeutic means (cytostatics, antibiotics, radiation therapy), it is not recommended to use along with high doses glucocorticosteroid drugs because the immunosuppressive effect caused by high doses of glucocorticosteroid medicines levels immunopromoting effect of drug.

Special indications

of Feature of influence of medicine on ability to run the vehicle or other potentially dangerous mechanisms

Drug does not affect ability to run vehicles and to be engaged in other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions.


Symptoms: at 10-fold exceeding a single dose the grippopodobny syndrome is possible.

Treatment: symptomatic therapy is shown.

A form of release and packing

On 10 ml in bottles of dark glass or polymeric bottles import. In a bottle install the aerosol valve with a raspylitelny head and a cap or the import pump doser with the plastic body, a nozzle and a protective cap. Quantity of doses in a bottle not less than 80.

On one bottle together with the instruction for medical use in the state and Russian languages place in a box of cardboard.

To Store storage conditions at

a temperature not higher than 25 S. Hranit out of children’s reach!

2.5 years

not to use a period of storage after an expiration date.

Prescription status

Without prescription

CJSC Mediko-biologichesky Producer the Cytohoney scientific-industrial complex, Russia, 191023, St. Petersburg, Muchnoy Lane, 2,
ph./fax (812) 315-88-34,

the Owner of the registration certificate

of CJSC Mediko-biologichesky the Cytohoney scientific-industrial complex, Russia.

The address of the organization accepting claims from the consumer on quality of drug in the territory of the Republic of Kazakhstan:

Pharmaline LLP,
Republic of Kazakhstan, 050050, Almaty, Shamiyeva St., 11, ph.: (727) 338-48-14 (15), e-mail:


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