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Mikonaz 2% oral gel 20g


Brands:: MUP (Egypt)


The instruction

for medical use

of Mikonaz Torgovoye medicine a name


Mezhdunarodnoye the unlicensed

name Miconazolum Dosage Form Gel of oral, 2%


of 100 g of gel

excipients contain active agent Miconazolum of 2 g: sorbitol solution of 70%, glycerin, sodium salt of carboxymethylcellulose, Natrium benzoicum, oil orange, citric acid monohydrate, polysorbate 80, water

the Pharmacotherapeutic group cleaned the Description the White or almost white viscous gel, uniform, which is easily distributed with pleasant sweet taste

Antimicrobial drugs for topical treatment of diseases of an oral cavity. Miconazolum.

The ATX A01AB09 code

the Pharmacological

Pharmacokinetics Miconazolum properties is completely soaked up from a GIT after oral reception.

Metabolism is carried out in a liver with discharge of inactive metabolites with urine and with a stake.

Oral absorption of 20%

Plasma elimination half-life

Linking with proteins of plasma of 91-93%

Obyem distributions of 20 l/kg

About 40% of an oral dose is allocated 24.1 hour in Calais in not changed look, other 40% are allocated in the same way in the form of metabolites.

The pharmacodynamics

Miconazolum is the imidocindery antifungal agent having fungicide and bactericidal activity against dimorphous fungi, dermatophytes and fungi of the sort Candida, including Candida albicans, Dimorphons fungi, Cryptococcus neoformans, Pityrosporum sp, Torulopsis glabrata and also against some gram-positive bacilli and cocci. In compliance with it

Mikonaz oral gel is effective at treatment of infections of an oral cavity and GIT, in particular, the caused Candida albicans fungus.

At low concentration of Miconazolum nitrate interacts with fungal cytochrome P – 450 which influences suppression of a step of demethylation in ergosterol biosynthesis. Impoverishment by ergosterol and the accompanying accumulation of a lanosterol is led to changes in a number of the functions connected with a membrane. At high concentrations Miconazolum interacts with lipids of membranes, causing their direct destruction with the subsequent spreading of contents of a fungal cell. At Candida albicans Miconazolum eventually inhibits a blastospor in an invasive filamentous form.


– prevention and treatment of oral, pharyngeal, ezofagealny, intestinal candidiases

the Route of administration and doses

is recommended to take the Drug after a meal.

To children since two years and the adult: & frac12, a teaspoon (2.5 ml) 4 times a day

Drug need to be held in a mouth, as long as possible.

Course of treatment of 7-14 days.

Side effects

After oral use of Miconazolum were noted the following side reactions:

– from digestive tract: nausea, vomiting and very seldom diarrhea (usually at long-term treatment).

– from the immune system (very seldom): allergic states, including a Quincke’s disease and anaphylactic reactions, a Lyell’s disease, Stephens’s syndrome of Johnson, urticaria, rash.

– from a liver and biliary tract it is (very rare): hepatitis

(isolated cases)


– hypersensitivity to drug ingredients

– a liver or renal failure and congenital abnormal liver functions

– pregnancy and the period of a lactation

Medicinal interactions

Miconazolum is contraindicated at joint use with the following drugs: astemizol, tsizaprid, dofetilid, mizolastin, Pimozidum, quinidine, sertindol, terfenadin.

Special instructions

For exact dosing the graduated measured spoon is applied.

Features of influence of drug on ability to run motor transport and potentially dangerous mechanisms

the Overdose

Symptoms does not influence: in a type of careless overdose, vomiting and diarrhea can be observed.

Treatment: symptomatic and maintenance therapy

the Form of release and packing

On 20 g of drug in the aluminum varnished tuba.

Each tuba together with a spoon doser and the instruction for medical use in the state and Russian languages is placed in a pack from cardboard

Storage conditions

to Store at a temperature not over 30 With

To store out of children’s reach!

A period of storage

4 years

After expiry date not to use drug!

Prescription status

Without prescription

the Producer Medikal Union Pharmasyyutikals, Egypt.

36, Mohamed Hassan El-Gamal St., 6th area, Nasr of City, Cairo 11471, P.o. box 7010.

The owner of the registration certificate

Medikal Union Pharmasyyutikals, Egypt

the Address of the organization of the claim accepting in the territory of the Republic of Kazakhstan from consumers on quality of products (goods)

Representative office Medikal Union Pharmasyyutikals in RK.

Address: Almaty 050040, Shashkina of a 36-, quarter 1,

ph./fax: 8 (727) 263 56 00,


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