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Deriva 0.1% 15g gel tube aq.




The instruction
for medical use

of Deriva medicine water gel

the Trade name
Deriva water gel

the International unlicensed

name Adapalen Lekarstvennaya a form
Gel of 0.1%

of 1 g of gel contains
active agent – adapalen 1 mg
excipients: dinatrium edetat, carbomer 940, glycol, methylparaben, phenoxyethanol, a polaksamer 407, sodium hydroxide, water purified is sawn through.

The description
Opaque gel of white color

the Pharmacotherapeutic group
Retinoids for topical treatment of acne rash
the Code of automatic telephone exchange D10AD03

the Pharmacological
Absorption Adapelen properties, gel through skin is improbable. Adapalen represents new generation of synthetic retinoids and is derivative naphthoic acid. Adapalen possesses sebostatichesky, komedonolitichesky and anti-inflammatory action. Drug influences a follicular hyperkeratosis, regulating process of keratinization and desquamation, influences the opened and closed comedones, prevents formation of microcomedones. The main mechanism of action – selection linking with nuclear RAq-receptors of cells of epidermis unlike not selective binding of retinoids of the previous generations. This mechanism regulates a final differentiation of keratinotsit that provides normalization of process of keratinization and reduction of prerequisites for forming of microcomedones. The inhibition of a lipoxygenase, arikhidonovy acid, cytokines has the significant anti-inflammatory effect. Influences inflammation factors. Adapalen does not possess the photosensitizing action.

– topical treatment of vulgar eels.

The route of administration and doses
apply Drug to previously cleaned and dry skin a thin layer, evenly, without rubbing, on affected areas of skin once a day (to protect eyes and lips). The therapeutic effect develops after 4-8 weeks of therapy. Carrying out repeated courses according to the recommendation of the doctor.

Side effects
– reactions of local character: burning sensation, reddening, peeling, xeroderma

of the Contraindication
– hypersensitivity to an adapalen or other components of drug
– a liver and renal failure
– the expressed lipidemia
– pregnancy
– the lactation period
– children’s age up to 12 years

Medicinal interaction
Deriva gel can potentially provoke irritation of skin. Joint appointment with drugs of topical administration (medical or abrasive soap or the cleaning means, cosmetics which possesses strong drying up irritant action and products with high concentration of alcohol, astringents, means with spices) should be used with care. With extra care it is necessary to apply the means for skin containing sulfur, resorcin or salicylic acid together with Deriva gel. If such drugs were applied to skin, then you should not begin the Deriva drug treatment until not to be terminated drugs completely.
Special indications
of the Precautionary measure
It is necessary to avoid contact Deriva of gel with mucous membranes of eyes, oral and nasal cavities. It is not necessary to apply on the eczematic, burned in the sun or damaged sites of skin, it is also not necessary to use it together with other keratolytic drugs of topical administration. It is necessary to avoid influence of UF and sunshine. After use it is dense to close a tube cover.
Throughout all course of treatment the drug Deriva and 1 month later after treatment, it is necessary to use reliable means of contraception. Use Deriva water gel in case of pregnancy planning is not recommended.
Pregnancy and the period of a lactation
Use of an adapalen during pregnancy and the period of a lactation is not recommended.
Influence of drug on ability to run transport or potentially dangerous mechanisms
does not influence.

Symptoms – strengthening of side effects.
Treatment – to stop drug use, to remove gel from the surface of skin with warm water.

Form of release and packing
Primary packing: an aluminum flexible tube with opaque white gel of moderate density.
Secondary packing: cardboard packing with one aluminum tube with the instruction for use.

To Store storage conditions in the dry place at a temperature not over 250C.
Not to freeze. To store out of children’s reach!

Not to apply a period of storage of 36 months after an expiration date.

Prescription status
According to the prescription

of Proizvoditel Glenmark Pharmasyyutiikals Ltd
the Address of the plant:
B/2, Makhalaksmi Chambers Ltd

22, Bkhulabkhay Disay Road Mumbai – 400,026, India
the Legal address:
Glenmark House,
HDO – the Corporate building
Winged And, B.D. Savant Marg
Sakala, office. A western the Express
Andheri’s Highway (East), Mumbai – 400099, India

Additional information



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