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Cyclodol 2 mg (50 tablets)




The instruction for use
of medicine for consumers
(summary insert)


Before use of medicine it is necessary to consult surely with the doctor and to attentively read the instruction!

A trade name

Grindex Mezhdunarodnoye Cyclodolum the unlicensed

name Trihexifenidil Lekarstvennaya a form
of the Tablet of 2 mg

One tablet contains
active agent – trihexifenidit a hydrochloride of 2 mg.
excipients: sucrose, potato starch, microcrystalline cellulose, calcium stearate.

The description
Round ploskotsilindrichesky tablets of white color with a facet.

Oral administration trihexifenidit the pharmacological Pharmacokinetics At properties quickly and it is completely soaked up from a digestive tract. The effect is reached within an hour. Elimination half-life of 5-10 hours. Trihexifenidil possesses a high lipotropnost, he well passes through hematoencephalic and placentary barriers. Trihexifenidil is hydrolyzed in fabrics under the influence of nonspecific esterases on alcohol and organic acids, a small part of a trihexifenidil is allocated in not changed look through kidneys.
The pharmacodynamics
Grindex Cyclodolum is a synthetic holinoblokator which reduces a tremor, characteristic of parkinsonism, muscle tension and a bradykinesia. Grindex Cyclodolum possesses strong m-holinoblokiruyushchim and weak N-holinoblokiruyushchim action. The mechanism of action is based on its ability to compete with acetylcholine on a postsynaptic membrane.

– parkinsonism
– the extrapyramidal disturbances caused

by the drugs Route of administration and doses
the Dosage is selected individually. The drug should be taken to food.
Begin reception with a dosage – 1 mg a day. The dose is increased gradually by 2 mg every 3-5 days. A usual maintenance dose – 6-10 mg a day, divided into 3-4 receptions. In hard cases there can be a need to increase a dose to 12-16 mg divided into 3-4 receptions. The maximum daily dose – 16 mg of a trihexifenidil. Duration of a course of treatment is appointed individually.
Upon termination of treatment or in case of the beginning of alternative treatment of a dose of a trihexifenidil it is necessary to reduce gradually.
Elderly patients are more sensitive to this drug therefore they should use smaller doses.
In children’s practice it is not used.

Side effects
– a mydriasis, accommodation disturbances, photophobia
– dryness in a mouth, sweating reduction, a constipation
– stomach aches, nausea.
– an urination delay
– tachycardia (it is very rare – bradycardia)
– hypersensitivity
– closed-angle glaucoma that is connected with increase in intraocular pressure therefore it is necessary to control intraocular pressure regularly.
– fatigue, drowsiness, dizziness, nervousness, insomnia,
a memory impairment
it is Very rare
– bradycardia

At use of high doses or at treatment of patients with the contributing factors (atherosclerosis, old age or patients with an idiosyncrasy on any medicine) can arise:
– turbidity of consciousness and other disturbances of mentality
– unnatural increase in mood, excitement, irritation
– vomiting or nausea
In this case it is necessary to stop treatment. At reduction of a dosage or the termination of treatment the side effects disappear.

– hypersensitivity to a trihexifenidil and/or excipients
– not treated delay of urination
– a benign prostatauxe with
an urination delay
– closed-angle glaucoma
– obstruction of a digestive tract
– a tachyarrhythmia
– acute intoxication alcohol, psychotropic medicines or opiates
– an acute delirium and a mania
– late dyskinesia (tardive dyskinesia) – pathological movements – side effect of prolonged use of antipsychotic medicines.

Medicinal interactions
Action of a trihexifenidil can amplify at use together with other holinoblokiruyushchy medicines with similar properties (for example, amantadin, some gistaminoblokator, derivatives of a fenotiazin, tricyclic antidepressants, etc.) and together with MAO inhibitors (they inhibit the enzymes metabolizing medicines). At use together with the called medicines there can be following side effects: dryness in a mouth, turbidity of sight, a delay of urination and zaporoshok
Trihexifenidil and parasympathomimetics work antagonistic.
At simultaneous use of a trihexifenidil the effect of the nitrates applied sublingual decreases (owing to dryness in a mouth).
Braking trihexifenidily motility of intestines can interfere with absorption of other medicines.
Trihexifenidil weakens impact of Metoclopramidum and a domperidon on a digestive tract.
Depressive effect of alcohol and other medicines can amplify at use with trihexifenidily.
At use together with a levodopa the dosage of both drugs needs to be reduced. Usually in this case 3-6 mg of a trihexifenidil a day divided into two receptions there are enough.

Special instructions
Very carefully should be applied trihexifenidit at elderly patients and at patients with cardiovascular diseases, with disturbances of functions of a liver and kidneys.
The care is necessary in the following cases: diseases which can lead to life-threatening tachycardia, a syndrome of dementia, myasthenia gravis, a prostatauxe with full bladder emptying.
Abuse cases trihexifenidily, especially at psychiatric patients are known (in connection with gallyutsioniziruyushchy and eyforiziruyushchy action).
It is necessary to consider that development of medicinal dependence is possible.
Treatment cannot be stopped suddenly.
Pregnancy and the period of a lactation
passes Drug through a placental barrier, is allocated with breast milk owing to what it is undesirable to use drug during pregnancy and feeding by a breast.
The feature of influence of medicine on ability to run vehicles or potentsialnoopasny mechanisms
Should be careful since drug influences speed of response.

High doses of a trihexifenidil cause blockade of the postganglionic terminations of parasympathetic nervous system, the picture of poisoning corresponds, in principle, to poisoning with atropine (mydriasis, dry mucous membranes, tachycardia, an atony of intestines and bilious ways, the increased body temperature, etc.). Trihexifenidil causes also disturbances from the central nervous system (irritability, consciousness disturbances, a derealization and other disturbances of mentality). In more serious poisoning there can be a coma or paralysis of a respiratory center.
Specific antidote is absent. It is necessary to carry out gastric lavage and to use other possible methods for medicine absorption reduction. Symptomatic treatment: cold compresses, plentiful drink. It is possible to apply cholinesterase inhibitors (for example, physostigmine), for treatment of warm complications were successfully used sodium bicarbonate or sodium a lactate, in spasms – diazepam, at deliriums – physostigmine.

A form of release and packing
of the Tablet on 2 mg, 25 tablets in the blister, on 2 blisters in a pack from cardboard together with the instruction for use.

To Store storage conditions in the place protected from light at a temperature not above 25 °C.
To store out of children’s reach!

Expiration date
of 5 years.
Not to apply after the expiration date specified on packing.

Prescription status
According to the prescription

Krustpils St., 53, Riga, LV-1057, Latvia.

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