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Clotrimazole 1% cream 15g in tube




The instruction for medical use

of CLOTRIMAZOLUM medicine cream of 1%

the Trade name


the International unlicensed

name Clotrimazolum Dosage Form Cream of 1% 15 G Structure of 1 G of Cream contains

active agent Clotrimazolum of 10 mg,

excipients: cetostearyl alcohol, octyllauryl alcohol, polysorbate 60, sorbitan monostearate, cetyl palmitate, benzyl alcohol, water purified.

The description

Uniform cream of white or almost white color

Pharmacotherapeutic group

Antifungal drugs for treatment of diseases of skin. Antifungal drugs for topical administration. Imidazole derivatives. Clotrimazolum

ATX D01AC01 Code.

The pharmacological

Pharmacodynamics Antifungal Drug properties of a broad spectrum of activity for external use from group of derivatives of an imidazole. The mechanism of effect of Clotrimazolum is connected with disturbance of synthesis of ergosterol, is a part of a cellular membrane of mushrooms that changes permeability of a membrane and causes the subsequent lysis of a fungal cell.

It is active concerning dermatophytes, yeast-like and mold mushrooms and also the activator multi-colored depriving (pityriasis versicolor) and the activator of an erythrasma. Has antimicrobic effect concerning gram-positive (streptococcus spp., staphylococcus spp.) and gram-negative bacteria (bacteroides spp., gardnerella vaginalis) and also concerning trichomonas vaginalis, corynebacterium minutissimum.

The pharmacokinetics

At external use active agent is practically not soaked up in a system blood stream and has no systemic action.


– the fungal infections of skin caused by the dermatophytes, mold and yeast-like mushrooms and other activators sensitive to Clotrimazolum

– a chromophytosis

– an erythrasma

– the mycoses complicated by a secondary pyoderma.

The route of administration and doses

Clotrimazolum recommend to apply cream 2-3 times a day with a thin layer on previously cleaned and dried up affected areas of skin. Duration of therapy is established individually depending on weight and localization of a disease. For achievement of an absolute recovery it is not necessary to stop treatment by cream at once after disappearance of acute symptoms of inflammation or subjective complaints.

Duration of therapy has to average 4 weeks, in a chromophytosis – 1-3 weeks, at an erythrasma – 2-4 weeks, in fungus diseases of skin of legs recommend to continue therapy within 2 weeks after stopping of symptoms of a disease.

Side effects

Seldom – reddening, pricking and pain in the site of application of cream, burning, an itching, allergic reactions, contact dermatitis, papules, hypostasis, a small tortoiseshell, skin cracks.


– hypersensitivity to drug components.

Medicinal interactions

decrease in antifungal effect of Clotrimazolum at simultaneous use with half-yen antibiotics (Amphotericinum B, nystatin) is possible. The dexamethasone applied in high doses slows down antifungal effect of Clotrimazolum. Anti-mycotic effect of Clotrimazolum is strengthened by high local concentrations of propyl ether of p-hydroxybenzoic acid.

Special instructions

It is necessary to avoid hit of cream on a mucous membrane of eyes.

In the absence of clinical improvement within 4 weeks of therapy, it is necessary to conduct a microbiological research for confirmation of the diagnosis and an exception of other cause of illness.

At emergence of hypersensitivity reactions or irritations use of drug it is necessary to stop and pick up other therapy.

Pregnancy and the period of a lactation

In clinical and pilot studies it is not established negative influence on health of the woman or a fruit (child) at cream Clotrimazolum use during pregnancy or breastfeeding.

The issue of expediency of prescribing of Clotrimazolum of cream has to be resolved individually after consultation of the doctor.

Putting Clotrimazolum of cream directly on skin of a mammary gland when breastfeeding is contraindicated.

Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms

Use of drug does not affect ability to driving of motor transport and control of potentially dangerous mechanisms.


So far about overdose cases by the drug Clotrimazolum cream it was not reported.

A form of release and packing

On 15 g of cream in an aluminum tuba. On 1 tuba together with the instruction for use in the state and Russian languages in a cardboard pack.

To Store storage conditions at a temperature not above 25C. Not to freeze.

To store out of children’s reach!

3 years

not to use a period of storage after an expiration date.

Prescription status

Without prescription.


Krinilor St., 5, the village Porumben, the area Kriulen,

the Republic of Moldova,

the Owner of the registration certificate


The address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods)

Representative office of LLC PHARMAPRIM in Republic of Kazakhstan, Almaty, Gogol St., 86, office 528, ph. 8-727-2796518,

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