The instruction for medical use of AYKROL medicine the Trade name Aykrol Mezhdunarodnoye the unlicensed name Kromoglitsiyevaya acid the Dosage form of the Drop eye 4%, 10 ml Structure of 1 ml of drug contains active agent – sodium kromoglikat 40 mg, excipients: a benzalkoniya chloride of 50% (100% a benzalkoniya are equivalent to chloride), dinatrium edetat, polysorbate 80, acid chlorohydrogen or sodium hydroxide, water for injections. The description Transparent liquid from colourless till weak-yellow color. Pharmacotherapeutic group Drugs for treatment of diseases of eyes. Decongestants and antiallergic drugs. Antiallergic drugs others. Kromoglitsiyevy acid. The ATX S01GX01 code the Pharmacological VsasyvaniePri’s Pharmacokinetics properties use of eye drops absorption of drug through a mucous membrane of an eye is insignificant. The system bioavailability is less than 0.1%. VyvedenieT1/2 makes 5-10 min. A pharmacodynamics Aykrol – antiallergic means which part disodium salt of kromoglitsiyevy acid is. The therapeutic effect consists in membrane stabilizing effect of kromoglitsiyevy acid which interferes with degranulation of mast cells and discharge from them of a histamine, bradykinin, leukotrienes (including, slowly reacting anaphylaxis substance), prostaglandins and other biologically active agents. The drug Aykrol is most effective at preventive use as it prevents development of allergic and inflammatory reactions. The full clinical effect in allergic diseases of eyes occurs within several days or weeks. Indications – prevention and treatment of acute, seasonal and year-round allergic conjunctivitis. The route of administration and doses to Adults and children are more senior than 8 years dig in on 1-2 drop 4% of solution in both eyes 3-4 times a day through equal intervals of time (at achievement of clinical effect the intervals between use gradually extend). Only on doctor’s orders. The course of treatment is defined by the attending physician. Side effects At topical administration Aykrol is usually well had and symptoms of irritation of eyes meet seldom. Often (& gt, 1/100) – the short-term burning sensation, local irritation of eyes and disturbance of clearness of visual perception is Very rare (& lt, 1/10000) – a chemosis, feeling of a foreign body, xerophthalmus, Contraindication dacryagogue – hypersensitivity to drug components – the children’s age up to 8 years Medicinal interactions Reduces the need for use of the ophthalmologic drugs containing glucocorticosteroids. Special instructions Aykrol is intended only for topical administration. If after use of eye drops the long time proceeds or conjunctival hyperaemia accrues, then it is necessary to stop use of drug and to see a doctor. As excipient to be a part of drug the benzalkoniya chloride. Chloride the benzalkoniya can form a deposit in soft contact lenses. Therefore, Aykrol it is not necessary to use when carrying contact lenses. When using contact lenses it is necessary to remove them before burying and again to dress in 15-20 min. after drug instillation. It is necessary to avoid touch of a tip of a dropper to any surfaces to avoid microbic pollution of contents of packing. The bottle needs to be closed after each use. It is not necessary to touch with a pipette tip an eye. Use in pediatrics the Efficiency and safety of use of Aykrol for children aged up to 8 years is not studied. Pregnancy and the period of a lactation At pregnancy use of eye drops Aykrol perhaps in case the advantage of its use exceeds risk for a condition of a fruit. In case of use of drug in the period of a lactation the breastfeeding should be stopped. Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms Right after instillation the illegibility of visual perception is possible that it can entail difficulties in driving and during the work with mechanisms. The overdose Overdose is improbable as local and system absorption – are insignificant. Symptoms: strengthening of side effect Treatment: symptomatic. The form of release and packing On 10 ml of drug place in a plastic bottle with a stopper dropper and the screwing-up protective cap supplied with a safety ring. On 1 bottle together with the instruction for use in the state and Russian languages in a cardboard box. To Store storage conditions in the place protected from light at a temperature not above 25 °C. To store out of children’s reach. The use period after the first opening of a bottle within 4 weeks. 3 years not to apply a period of storage after an expiration date. Prescription status Without prescription Producer E.I.P.I. To., Tens ov City Ramadan, the First B1 Industrial Zone, p.o. box 149 Tens, Egypt (E.I.P.I.CO. Tenth of Ramadan City, First Industrial Area B1, P.O. box: 149 Tenth, Egypt) the Owner of the registration certificate UORLD of OFTALMIKS MEDICINE, Great Britain the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products of RK, WM Pharma Alliance LLP, Almaty, Suyunbaya Ave., 222 B Ph. / fax: 8 (7272) 529090 Address of the organization responsible for post-registration observation of safety of medicine: TROKA-S PHARMA LLP, RK, Almaty, Suyunbaya Ave., 222 B
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