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Askofen-P (10 tablets)

$2.80

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Description

The instruction for use of medicine for experts Askofen P

Trade name

Askofen P

International unlicensed name

Is not present

the Dosage form

of the Tablet Structure In to one tablet contains:

Acetylsalicylic acid of 0.20 g

of Paracetamol of 0.20 g

of Caffeine of 0.04 g.

Excipients: potato starch of 0.0456 g, polyvinylpirrolidone of low-molecular 0.0024 g, stearic acid of 0.0025 g, calcium stearate of 0.0011 g, talc of 0.0064 g, emulsion of silicone 0.00125 g, liquid paraffin of 0.00075 g.

Description

of the Tablet of color, white or white with cream shade. On a surface of tablets the marbling is allowed.

Pharmacotherapeutic group

Analgetic, non-narcotic means.

Code of automatic telephone exchange NO2BA51

Pharmacological

Pharmacodynamics properties: Askofen P has anesthetic, febrifugal and psychogogic effect.

Acetylsalicylic acid possesses anesthetic, febrifugal and anti-inflammatory action, slows down aggregation of thrombocytes. Paracetamol has the febrifugal, anesthetizing effect. Caffeine reduces drowsiness and feeling of fatigue, increases intellectual and physical effeciency, increases heart rate, increases arterial blood pressure in hypotonia.

Pharmacokinetics: at intake about 90% of drug are soaked up, the level of the maximum concentration of paracetamol in serum is reached in 1 h, acetylsalicylic acid from 1 to 2 h, caffeine – 2.5 h. Period of semi-elimination of T1/2: for paracetamol – (1.68+0.13) h, for caffeine – (7.78 + 1.92) h. The maximum concentration of components of drug in blood: paracetamol – (8.18 + 0.39) mkg/ml, caffeine (8.16 + 0.25) mkg/ml. Time of achievement of the maximum concentration (Tmakh): paracetamol (0.86 + 0.12) h, caffeine – (2.42 + 0.18) h. Out of an organism of 80% of acetylsalicylic acid and paracetamol it is brought through kidneys.

Indications

Askofen P apply a route of administration and doses inside after a meal on 1-2 tablets 2-3 times a day. Maximum daily dose of 6 tablets. The break between receptions has to be not less than 6 hours.

In renal failures or a liver a break between receptions not less than 6 hours.

It is not necessary to take the drug more than 5-7 days when assigning as anesthetic and more than 3 days as febrifugal. Other dosages and schemes of use are established by the doctor.

Contraindications

the Increased individual sensitivity to drug components, a peptic ulcer of a stomach and duodenum, gastrointestinal bleedings, aspirinovy asthma, hemophilia, hemorrhagic diathesis, a prothrombinopenia, portal hypertensia, the profound abnormal liver functions or kidneys, genetic absence glyukozo-6-fosfatdegidrogenazy, blood diseases with tendency to hemorrhages, glaucoma, bronchial asthma, deficiency of vitamin K, pregnancy and the period of breastfeeding, children’s age (up to 12 years), the profound arterial hypertension, a heavy course of coronary heart disease, hyperexcitability, a sleep disorder, the surgical interventions which are followed by bleeding, simultaneous use of other non-steroidal anti-inflammatory drugs.

Drug is not appointed to children up to 15 years with the acute respiratory diseases caused by viral infections (a SARS, flu) because of danger of development of a syndrome Reja.

With care to apply in gout, liver diseases.

Side effects

Anorexia, nausea, gastralgia, diarrhea, digestive tract erosive cankers, gastrointestinal bleedings, liver and/or renal failure, increase in arterial blood pressure, tachycardia,

Allergic reactions: skin rash, Quincke’s edema, bronchospasm.

At long reception dizziness, a headache, disorders of vision, sonitus, decrease in aggregation of thrombocytes, hypocoagulation, a hemorrhagic syndrome (nasal bleeding, bleeding of gums, purple, etc.), damage of kidneys with papillary necrosis, deafness, Stephens-Johnson’s syndrome, a toxic epidermal necrolysis (Lyell’s disease), a syndrome Reja at children (a hyper pyrexia, a metabolic acidosis, disturbances from nervous system and mentality, vomiting, abnormal liver functions).

Overdose

Symptoms in slight poisonings: nausea, vomiting, stomach aches, perspiration, pallor of integuments, tachycardia. At suspicion of poisoning it is necessary to ask for medical assistance immediately.

At in a serious poisoning confusion of consciousness, the incoherent speech, drowsiness, collapse, spasms, a bronchospasm, the complicated breath, an anury, bleedings. Originally central hyperventilation of lungs leads to a respiratory alkalosis (short wind, suffocation, cyanosis, a perspiration). In process of strengthening of intoxication – the progressing paralysis of breath and dissociation of oxidizing phosphorylation causes respiratory atsidozirovanny

Treatment: to stop administration of drug. The victim should cause vomiting or to make gastric lavage and to appoint adsorbents (activated carbon) and laxatives, restoration of volume of the circulating blood forcing of a diuresis (intensive infusion it is dangerous by a fluid lungs, especially at elderly). In a fluid lungs to carry out IVL with oxygen mix. In hard cases the hemodialysis is shown. Treatment should be carried out only in the conditions of a specialized hospital.

Medicinal

Pharmakodinamicheskoye’s vzaimodeystviiya. Strengthens effect of heparin, oral anticoagulants, reserpine, steroid hormones and hypoglycemic means. Reduces efficiency of Spironolactonum, furosemide, hypotensive drugs, the antigouty means promoting removal of uric acid.

Strengthens side effects of glucocorticosteroids (GKS), derivative sulphonylurea, a methotrexate, non-narcotic analgesics and NPVP.

It is necessary to avoid a drug combination with barbiturates, antiepileptic means, a zidovudine, rifampicin and etanolsoderzhashchy drinks (the risk of hepatotoxic effect increases).

Pharmacokinetic. Under the influence of paracetamol time of removal of chloramphenicol increases by 5 times. Caffeine accelerates ergotamine absorption.

Special instructions

Askofen P are a part the components capable to cause teratogenic effect on a fruit therefore use of drug during pregnancy and a lactation is forbidden.

Askofen P can be allowed for clinical use, but with use restriction to his children to 12 years and also during pregnancy and breastfeeding owing to presence of genotoksichesky effects of components of drug.

drug significantly does not affect ability to run transport and works with other dangerous mechanisms.

At long use of drug the control of peripheral blood and a functional condition of a liver is necessary. As acetylsalicylic acid has anti-aggregation effect, the patient if surgical intervention is necessary to it, has to warn the doctor about administration of drug in advance. Patients with hypersensitivity or with astmoidny reactions to salicylates or their derivatives, acetylsalicylic acid can appoint only with observance of special precautionary measures. Acetylsalicylic acid in low doses reduces removal of uric acid. At patients with the corresponding predisposition – it can provoke a gout attack in some cases.

Drug has teratogenic influence, at use in the I trimester of pregnancy leads ment splitting of the upper sky at a fruit, in the III trimester causes slowing down of patrimonial activity (inhibition of synthesis of prostaglandins), premature closing of an arterial channel in a fruit, a hyperplasia in a small circle of blood circulation. Consequences for a fruit at consumption of aspirin at pregnancy neonatal bleeding, intracranial bleeding at premature, persistent hypertensia of a pulmonary artery. Drug is not recommended to inclusion in the pregnancy period.

During treatment it is necessary to refuse consumption of alkogolsoderzhashchy drinks (increase in risk of gastrointestinal bleeding).

Drug significantly does not affect ability to run transport and works with other dangerous mechanisms.

A form of release

of the Tablet combined. On 10 tablets in planimetric bezjyacheykovy or strip packaging. 1 or 2 blister strip packagings in a cardboard pack.

To Store storage conditions at a temperature not higher than not higher than 25C in the dry, protected from light place inaccessible for children.

Expiration date

2 years. Not to use after the expiration date specified on packing.

Prescription status

Without prescription of the doctor.

Producer

of JSC Pharmstandard-Leksredstva, 305909, Russia, Kursk, 2nd Agregatnaya St., 1a/18.

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