Instruction for use Ingredients: the tablet covered with a kishechnorastvorimy cover contains Active agent: ademetionin (in the form of an ademetionin of the 1.4-butandisulfonat) 400 mg. Excipients: microcrystalline cellulose, sodium krakhmalglikolit, silicon dioxide colloidal anhydrous, magnesium stearate. Structure of a cover: ferrous oxide yellow (E1 72), ferrous oxide red (E1 72), eudragit L-100-55, a macrogoal 6000, polysorbate 80, simetikon, sodium hydroxide, talc. The description the Oval dvoyakovypukpy tablets covered with a kishechnorastvorimy cover, salmoncolored color. Ademta treats group of gepatoprotektor, has to a tayuka antidepressive activity. Has holeretichesky and holekinetichesky effect, has the detoksikatsionny, regenerating, antioxidant, antifibroziruyushchy and neuroprotective properties. Fills shortage S-adenozil-Lmetionina (ademetionina) and stimulates its development in an organism, will restrain in all environments of an organism. The highest concentration of an ademetionin is noted in a liver and a brain. Ademetionin carries out a key role in metabolic processes of an organism, takes part in important biochemical reactions: transmethylation, transsulphonating, transamination. In transmethylation reactions ademetionin tints methyl group for synthesis of phospholipids of cellular membranes, neurotransmitters, nucleic acids, proteins, hormones, etc. In transsulphonating reactions ademetionin is a predecessor of cysteine, taurine, glutathione (providing the oxidation-reduction mechanism of a cellular detoxication), coenzyme A (joins in biochemical reactions of a cycle of tricarboxylic acids and fills energy potential of a cell). Ademta increases the maintenance of a glutamine in a liver, cysteine and taurine in plasma, reduces methionine content in serum, normalizing metabolic reactions in a liver. After decarboxylation participates in aminopro-milling reactions as the predecessor of polyamines – a putrestsin (stimulator of cell regeneration and proliferation of hepatocytes), the spermidine and spermine entering into structure of ribosomes that reduces risk of fibrosing. Has holeretichesky effect. Ademetionin normalizes synthesis of endogenous phosphatidylsincaline in hepatocytes that increases the fluidity and polarization of membranes. It improves function of the hepatocytes of the transport systems of bile acids associated with membranes and promotes a passage of bile acids in biliary tract. It is effective at intra lobular option of a cholestasia (disturbance of synthesis and current of bile). Ademetionin reduces toxicity of bile acids in a hepatocyte, carrying out their konjyugirovaniye and sulphation. Conjugation with taurine increases solubility of bile acids and their removal from a hepatocyte. Process of sulphation of bile acids promotes a possibility of their elimination by kidneys, facilitates passing through a membrane of a hepatocyte and removal with bile. Except this, the sulphated bile acids in addition protect liver cell membranes from toxic effect of not sulphated bile acids (in high concentrations of attendees in hepatocytes at an intra hepatic cholestasia). At patients with diffusion diseases of a liver (cirrhosis, hepatitis) with a syndrome of an intra hepatic cholestasia ademetionin reduces severity of a skin itching and changes of biochemical indicators, including level of direct bilirubin, activity of alkaline phosphatase, aminotransferases, etc. the Holeretichesky and gepatoprotektivny effect remains up to 3 months after the treatment termination. The efficiency at the gepatolatiya caused by various hepatotoxic drugs is proved. Appointment to patients with the opioid drug addiction which is followed by damage of a liver leads to regression of clinical manifestations of abstinency, improvement of a functional condition of a liver and processes of microsomal oxidation. The antidepressive activity is shown gradually, since the end of the first week of treatment and is stabilized within 2 weeks of treatment. It is effective in the recurrent endogenous and neurotic depressions resistant to amitriptyline. Has ability to interrupt a depression recurrence. Appointment in osteoarthrites reduces expressiveness of a pain syndrome, increases synthesis of proteoglycans and leads to partial regeneration of cartilaginous tissue. Tablets are covered with the film cover which is dissolved only in intestines thanks to what ademetionin it is released in a duodenum. The bioavailability at intake is 5%, increases at reception on an empty stomach. The maximum concentration (Cmax) of an ademetionin in plasma are dose-dependent and leave 0.5-1 ml/l in 3-5 hours after Single dose inside in doses from 400 mg to 1000 mg. Cmax of an ademetionin in plasma decrease to initial level within 24 hours. Communication with proteins of blood plasma insignificant, makes 5%. Gets through a blood-brain barrier. Significant increase in concentration of an ademetionin in cerebrospinal fluid is noted. It is metabolized in a liver. Process of education, expenditure and repeated formation of an ademetionin is called a cycle of an ademetionin. At the first stage of this cycle the ademetioninzavisimy methylelements use ademetionin as substrate for products of S-adenozilgomotsisteina which then is hydrolyzed to a gomotsistein and adenosine by means of S-adenozilgomotsisteingidralazy. Gomotsistein, in turn, is exposed to the return transformation to methionine by transfer of methyl group from 5 methyltetrahydrofolates. As a result methionine can be transformed in ademetionin, finishing a cycle. Elimination half-life (T1/2) – the 1, 5 hour. It is removed by kidneys. Indications – fat dystrophy of a liver, – chronic hepatitis, – toxic damages of a liver of various etiology, including alcoholic, virus, medicinal (antibiotics, antineoplastic, lrotivotuberkulezny and antiviral drugs, tricyclic antidepressants, oral contraceptives), – chronic acalculous cholecystitis, – a cholangitis, – tsirrozpechen, – the encephalopathy of secondary genesis including associated with a liver failure (alcoholic, etc.). An intra hepatic cholestasia at pregnant women. Depression. As a part of complex therapy of osteoarthrites. The Tablet route of administration, covered with a kishechnorastvorimy cover, accept inside, entirely, without chewing, it is desirable in the first half of day between meals. Tablets should be taken out from the blister just before intake. In case tablets have color, other than described in the instruction. drug is not recommended to be used. The recommended daily dose makes 2-4 tablets (from 800 mg to 1600 mg a day). Duration of therapy is defined by the doctor. Elderly patients (65 years are more senior) Clinical experience of use did not reveal any differences in its efficiency at elderly patients and patients of younger age. However, considering a high probability of the available abnormal liver functions, kidneys or heart, other accompanying pathology or simultaneous therapy with other medicines. elderly patients should select a drug dose with care. beginning use of drug with the lower limit of range of doses (1 – 2 tablet a day). Patients with a renal failure of Researches at patients with a renal failure it was not carried out. in this regard it is recommended to be careful at use for such patients. Patients with a hepatic nedostapyuchnost Parameters of pharmacokinetics of an ademetionin are similar at healthy volunteers and at patients to chronic diseases of a liver. A form of release of the Tablet, covered with a kishechnorastvorimy cover. 10 tablets in the blister. 2 blisters together with the instruction for use in a cardboard box. To Store storage conditions at a temperature not above 25 °C. To store out of children’s reach! Expiration date 3 years. Not to apply after an expiration date. Implementation conditions Through pharmacy chain and specialized shops. departments of retail chain stores. Dietary supplement to food. Is not medicine. The owner of a trademark and the certificate of registration is the DR SERTUS ILACH SANAYI BE TIDZHARET LIMITED of SHIRKETI company, TURKEY Is made Ward of Medicine Ilach Sang ve by Tidzh A.Sh. Turkey, Istanbul
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