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Vermoxum 100 mg (6 tablets)




The instruction for medical use of VERMOXUM medicine the Trade name Vermoxum the International unlicensed name Mebendazolum Dosage Form of the Tablet, 100 mg Structure One tablet contains active agent – Mebendazolum of 100 mg excipients: sodium lauryl sulfate, silicon dioxide colloidal anhydrous, magnesium stearate, sodium saccharin, talc, starch corn, lactoses monohydrate. The description of the Tablet of a ploskotsilindrichesky form with a facet, white or almost white color, with the inscription Vermox on one party and risky on another, with a light characteristic smell, with a diameter about 10.0 mm. Pharmacotherapeutic group Anthelminthic means. Drugs for treatment of nematodoses. Benzimidazole derivatives. Mebendazolum. The ATX P02CA 01 code the Pharmacological Pharmacokinetics Mebendazolum properties is a little absorbed at oral administration. In the recommended (sredneterapevtichesky) dose drug has low bioavailability owing to the significant presistemny metabolism and very low solubility of medicinal substance. 90% of drug contact proteins of plasma. The bioavailability increases at a concomitant use of drug with greasy food. It is removed mainly in not changed view with a stake. The pharmacodynamics Vermoxum represents synthetic anthelminthic drug of a broad spectrum of activity. Means influences formation of a tubulin in cells of helminths that leads to disturbance of capture of glucose and normal digestive function at helminth in such degree that autolytic processes are started. The indications of the Disease caused by invasions: – an enterobiosis (Enterobius vermicularis) – an ascaridosis (Ascaris lumbricoides) – a trichinosis (Trichuris trichiura) – ankilostomidoz (Ancylostoma duodenale) – a necatoriasis (Necator americanus) – a strongyloidosis (Strongyloides stercoralis) – a teniosis (Taenia spp) – the mixed gastrointestinal invasions. A route of administration and doses In an enterobiosis: To children 2 years and the adult irrespective of body weight – 100 mg of drug (1 tablet) once are more senior. Treatment should be repeated in 2 – 4 weeks, in view of a frequent recurrence of an infection. Simultaneous treatment of all family members is recommended. In an ascaridosis, a trichinosis, an ankilostomidoza and multi-infections: To children 2 years and the adult within 3 days on 200mg/days are more senior (on 1 tablet in the morning and in the evening). In a teniosis, a strongyloidosis: – the adult within three days on 2 tablets in the morning and in the evening (400mg/days), – to children within three days on one tablet in the morning and in the evening (200mg/days). Use for children: The tablet can be chewed or swallowed entirely. At use for small children age up to 6 years the tablet has to be pounded in powder. Side effects Very seldom (& lt, 1/10,000) – spasms at children of chest age – abdominal pain, diarrhea (invasions can be a consequence) – reactions of hypersensitivity as anaphylactic and anaphylactoid reactions – a toxic epidermal necrolysis, Stephens’s syndrome – Johnson, rash, a Quincke’s disease, urticaria Frequency is unknown (there is no authentic statistics) – a neutropenia At use in high doses for a long time: Frequency is unknown (there is no authentic statistics) – an abnormal liver function, hepatitis – the Contraindication glomerulonephritis – hypersensitivity to any of drug components – hereditary intolerance of a galactose, lactose, a lactose intolerance, malabsorption of a glucose/galactose – pregnancy and the period of a lactation – the children’s age up to 2 years Medicinal interactions Co-administration of Cimetidinum with Mebendazolum increases concentration of the last in plasma at long-term treatment. Definition of concentration of drug in plasma, for providing necessary doses of both medicines is recommended. It is necessary to avoid simultaneous use of Mebendazolum and metronidazole. Special instructions At prolonged use the control of the general blood test, function of a liver, kidneys is necessary. Drug is incompatible with alcohol. During treatment there is no need for prescribing of depletive and observance of a diet. Vermoxum reduces the need for insulin at patients with diabetes. At patients with an abnormal liver function it is necessary to show care at drug use. In case of a lactose intolerance, it is necessary to consider that each tablet of drug contains 110 mg of lactose of monohydrate. Features of influence of medicine on ability to run the vehicle and potentially dangerous mechanisms Vermoxum does not affect ability to driving of the car and control of working mechanisms. Overdose Symptoms: abdominal pain of spasmodic character, nausea, vomiting, diarrhea. Treatment: there is no specific antidote. In the first hour after overdose – gastric lavage, intake of activated carbon. A form of release and packing On 6 tablets in blister strip packaging from a film of polyvinylchloride and aluminum foil. On 1 blister strip packaging together with the instruction for medical use in the state and Russian languages put in a cardboard box. To Store storage conditions at a temperature from 15 ºС up to 30 ºС. To store out of children’s reach! Not to use a period of storage of 5 years after expiry date. Prescription status According to the prescription the Name and the country of the manufacturing organization Gideon Richter Romania A.O., Romania the Name and the country of the owner of the registration certificate of JSC Gideon Richter, Budapest, Vengriya Naimenovaniye i derzhatel litsenzii Janssen Pharmaceutica, Belgiya Adres organizatsii, prinimayushchey na territorii Respubliki Kazakhstan pretenzii ot potrebiteley po kachestvu produktsii Predstavitelstvo JSC Gideon Richter in RK E-mail: Phone number: 8-(7272)-58-26-22, 8-(7272)-58-26-23 The name, the address and a contact information of the organization in the territory of the Republic of Kazakhstan responsible for post-registration observation of safety of medicine: Representative office of JSC Gideon Richter in RK

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