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Urofuragin 50 mg (30 tablets)




The instruction for medical use of Urofuragin Torgovoye medicine a name Urofuragin Mezhdunarodnoye the unlicensed name Is not present the Dosage form of the Tablet, 50 mg Structure One tablet contains active agent – furagin 50 mg, excipients: corn starch, sucrose, silicon dioxide colloidal, stearic acid the Description of the Tablet of round shape of yellowish-orange color, with a flat surface on both sides, with risky on one party, with a diameter from 6.65 to 7.35 mm. Pharmacotherapeutic group Antimicrobial drugs for system use. Other antibacterial drugs. Nitrofuran derivatives. The ATX J01XE code the Pharmacological Pharmacokinetics Later properties of oral administration furagin is soaked up very quickly and reaches the maximum concentration in blood serum approximately in 0.5 hours. The course of curve concentration of drug in serum indicates an open uniform distribution model. This concentration is very important from the therapeutic point of view and makes about 4.2 mkg/ml. Binding of derivatives of nitrofuran is defined proteins of plasma by differently different authors: from 40-60% to 90-95%. This drug is metabolized in a liver and in peripheral fabrics. About 13% of a dose of a furagin are removed in an invariable look during the first day of reception. Observed average concentration of a furagin in urine are in range from the minimum inhibiting concentration (MIC) for about 81% of the pathogenic strains of colibacillus (E.coli) which are most often allocated from urine of children. They vary from 0.45 mg/ml to 6.25 mg/ml. A pharmacodynamics Furagin (nitrofuriloakrilidino-amino-hydantoin) represent nitrofuran derivatives. Drugs of this group have bacteriostatic action on a wide range of microorganisms, including some gram-positive bacteria (Staphylococcus epidermidis, Staphylococcus aureus, Staphylococcus faecalis) and many strains of gram-negative bacteria (Enterobacteriaceae: Salmonella, Shigella, Proteus, Klebsiella, Escherichia, Enterobacter). Derivatives of nitrofuran have antiparasitic effect and only small antifungal action. Does not influence pyocyanic sticks (Pseudomonas aeruginosa) and the majority of strains of bacilli of discrepancy (Proteus vulgaris). The strongest action furagin shows in acidic environment (rn 5.5), the alkaline environment weakens its action. Strong bacteriostatic action of a furagin is connected with presence of the aromatic deputy from nitrogroup. Derivatives of nitrofuran come down to active derivative bacterial flavoproteins. These derivatives then are transformed to the bacterial ribosomal proteins and other connections necessary for synthesis of cellular proteins, nucleic acids (DNA and RNA) and also in processes of cellular respiration. Emergence of cross resistance to antibiotics of derivatives of nitrofuran and streptocides was not observed. Indications – acute and persistent infections of urinary tract (pyelonephritis, cystitis, an urethritis) and a prostate (prostatitis), – postoperative infections of an urinogenital system (postoperative pyelonephritis, cystitis, prostatitis). The route of administration and doses of the Tablet Urofuragin accept inside after a meal, washing down with enough water. The adult appoint 100-200 mg 2-3 times a day. The course of treatment makes 7-10 days and depends on disease severity and also on a functional condition of kidneys. If necessary the course of treatment is repeated in 10-15 days. To children 6 years are more senior: 5-8 mg/kg of body weight a day, having divided a daily dose into 3-4 single doses, within 7-8 days. Side effects Sometimes – a loss of appetite, nausea, – vomiting, diarrhea, – dizziness, drowsiness, a disorder of vision, – fever. Seldom – a polyneuropathy, – papular rash, an itching, a small tortoiseshell, a passing alopecia. Very seldom – short wind, rapid breathing, cough without or with a phlegm, – pancreatitis, – other: fervescence, weakness, acute or chronic pulmonary reactions, – a Quincke’s disease, exfoliative dermatitis, Erythemamultiforme, – an agranulocytosis, thrombocytopenia, aplastic anemia, – an arthralgia. In some cases – cholestatic jaundice, hepatitis, abnormal liver functions – disturbances of a cardiovascular system: easy degree of intracranial hypertensia, – fervescence, weakness. In case of development of side effects it is necessary to reduce a dose or to stop administration of drug. Side effects decrease if the drug is taken after a meal, washing down with a large amount of liquid. Urofuragin can paint urine in brown color. Contraindications – hypersensitivity to derivatives of nitrofuran or to any of its components – a renal failure (clearance of creatinine less than 60 ml/min. or the increased creatinine level) – a polyneuropathy (including diabetic), – deficiency of glyukozo-6-phosphate – pregnancy and the period of a lactation – children’s age up to 6 years Medicinal interactions Furagin is an antagonist of Acidum nalidixicum which interferes with his bacteriostatic action. The Aminoglikozidny antibiotics and tetracycline accepted together with furaginy strengthen antibacterial action. Chloramphenicol and Ristomycinum increase haemo toxic action of a furagin. Uricosuric means, such as probenetsid (in high doses) and Sulfinpyrazonum reduce canalicular secretions of derivatives of nitrofuran and can cause accumulation of a furagin in an organism, increasing its toxicity and reducing concentration in urine is lower than the minimum bacteriostatic concentration and therefore, reducing therapeutic effect. At joint intake of the antiacid drugs containing magnesium trisilicate reduces absorption of a furagin. Atropine delays absorption of derivatives of nitrofuran, but the total amount of the absorbed substance does not change. The concomitant use of vitamins of group B increases absorption of derivatives of nitrofuran. At reception of derivatives of nitrofuran, false positive results for definition of glucose in urine with use of solutions of Benedict and Felinga were observed. The results of definition of glucose in urine received by enzymatic methods were correct. Special instructions patients Should be careful with disturbances of functions of kidneys, in anemia, a vitamin deficiency of group B and folic acid, in diseases of lungs (at patients 65 years are more senior). At long intake of nitrofuran the neuritis inside can develop. In case of long therapy it is necessary to control functions of lungs and a liver, especially at patients 65 years are more senior. With care it is necessary to apply nitrofuran sick diabetes since drug can contribute to the development of a polyneuropathy. The laboratory research of the patients accepting furagin can give false positive reaction to presence of glucose in urine if for definition the copper restoration method is used. furagin does not influence the results of definition of glucose in urine executed by an euzymatic method. In case of long intake of nitrofuran it is necessary to control periodically quantity of leukocytes in blood and also indicators of functions of a liver and kidneys in order to avoid development of undesirable by-effects. Drug contains sucrose. Sukraza-isomaltase is not recommended to accept it to patients with rare hereditary problems, problems intolerance of fructose, malabsorption of glucose galactose or deficit. Features of influence on ability to run the vehicle or potentially dangerous mechanisms As drug can make dizziness and sick during treatment it is necessary to avoid potentially dangerous types of activity connected with need of concentration of attention and the increased speed of psychomotor reactions. Overdose Symptoms: headache, dizziness, allergic reactions, nausea, vomiting, anemia. Treatment: it is recommended to carry out gastric lavage and intravenous injection of liquids, to make complete analysis of blood, laboratory analyses of a liver and monitoring of function of lungs. In hard cases, it is necessary to carry out a hemodialysis. The form of release and packing On 30 tablets place in blister strip packaging from a film of polyvinylchloride and aluminum foil. On 1 planimetric packing together with the instruction for use in the state and Russian languages put in a cardboard pack. To Store storage conditions at a temperature not over 25 of 0C to Store out of children’s reach! A period of storage 3 years Prescription status According to the prescription Pharmaceutical Works Polfa in Pabianice Joint Stock Company 5, marsz Producer. J. Piłsudskiego Str., 95-200 Pabianice, Poland Owner of the registration certificate of Adamed Consumer Healthcare S.A. Pienków 149, 05-152, Czosnów, Poland the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods) Representative office of JSC Pabianice Pharmaceutical Plant Polfa in PK 059000, Almaty, the street of Abay, house 109B, business center “Globus”, floor 13, office 13-2. Ph. / fax: +7 (727) 2776977. E-mail:
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