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Description
The instruction for medical use of RENGALIN medicine the Trade name Rengalin Mezhdunarodnoye the unlicensed name Is not present the Dosage form of the Tablet for resorption Structure One tablet contains active agents: Antibodies to bradykinin affinely cleaned – 0.006 g *, Antibodies to a histamine affinely cleaned – 0.006 g *, Antibodies to morphine affinely cleaned – 0.006 g * excipients: izomalt, cellulose microcrystalline, magnesium stearate, citric acid anhydrous, silicon dioxide colloidal, sodium cyclomate, sodium saccharin. * are put on izomalt in the form of mix of three active aqueous-alcoholic cultivations of the substance divorced respectively in 10012, 10030, 10050 times. The description of the Tablet of a ploskotsilindrichesky form, with a facet, with risky on one flat party, with integral edges, from white till almost white color. On the flat party from risky the inscription MATERIA MEDICA is put, on other flat party the inscription RENGALIN is put. Pharmacotherapeutic group Drugs for elimination of symptoms of cold and cough. Antibechic drugs. Antibechic drugs other the ATX R05DB Code the Pharmacological Pharmacokinetics Drug properties is homeopathic remedy. The sensitivity of modern physical and chemical methods of the analysis (gas-liquid chromatography, highly effective liquid chromatography, chromaTO-mass spectrometry) does not allow to estimate the content of active components of the drug Rengalin in biological liquids, bodies and fabrics that makes technically impossible studying pharmacokinetics. A pharmacodynamics it is Experimentally shown that components of drug modify activity a ligand – receptor interaction of endogenous regulators with the corresponding receptors: antibodies to morphine – with opiate receptors, antibodies to a histamine – with H1 histamine receptors, antibodies to bradykinin – with B1 bradykinin receptors, at the same time combined use of components leads to strengthening of antibechic effect. Except antibechic action, complex drug at the expense of the components entering it renders anti-inflammatory, antiedematous, antiallergenic, spasmolytic (antibodies to a histamine, antibodies to bradykinin) and analgeziruyushchy action (antibodies to morphine). The complex drug Rengalin due to modification a histamine – dependent activation of H1 – receptors and bradykinin – dependent activation of B2 – receptors selectively reduces excitability of the tussive center of a medulla, brakes the central links of a tussive reflex. Oppressing the centers of painful sensitivity in a thalamus, blocks transfer of painful impulses to a cerebral cortex. Inhibits a stream of a painful impulsation from the periphery owing to reduction of release of fabric and plasma algogen (a histamine, bradykinin, prostaglandins, etc.). Unlike narcotic analgetics does not cause respiratory depression, medicinal dependence, does not possess narcogene and somnolent action. Facilitates manifestations of acute pharyngitis and bronchitis, reducing a bronchospasm. Stops system and local symptoms of allergic reactions due to influence on synthesis and release of a histamine and bradykinin from mast cells. Indications as a part of complex therapy in acute respiratory diseases of upper airways followed by cough: acute pharyngitis, acute tracheitis, acute bronchitis. A route of administration and doses Inside, on one reception – 1 tablet (to hold in a mouth before full dissolution). To apply 1-2 tablets 3 times a day out of meal. Depending on weight of a state in the first three days the frequency of reception can be increased up to 4-6 times a day. Duration of treatment of 3-7 days, at preservation of cough more than 7 days it is necessary to see a doctor. Side effect reactions of the increased individual sensitivity to drug components Are possible. Contraindications – the increased individual sensitivity to drug components, – age up to 18 years (in connection with insufficiency of data on efficiency and safety), – pregnancy and the period of a lactation. Medicinal interactions of Cases of incompatibility with other medicines it is not registered so far. Special instructions Rengalin does not influence ability of control of vehicles and other potentially dangerous mechanisms. Influence of medicine for medical use on ability to run vehicles, Rengalin mechanisms does not influence ability of control of vehicles and other potentially dangerous mechanisms. Overdose At accidental overdose the dispepsichesky phenomena caused by the fillers which are a part of drug are possible. A form of release and packing of the Tablet for resorption. On 10 tablets in blister strip packaging from a film of polyvinylchloride and aluminum foil. On 2 blister strip packagings together with the instruction for medical use in the state and Russian languages place in a pack from cardboard. Storage conditions In the place protected from light, at a temperature not above 25 °C. To store out of children’s reach. 3 years not to apply a period of storage after an expiration date. Prescription status Without prescription the Producer/packer of LLC NPF MATERIA MEDIKA HOLDING, Russia, 127473, Moscow, 3rd Samotechny Lane, 9. Ph./fax: +7 (495) 684-43-33. Address of the production site of medicine Russia, 454139, Chelyabinsk, Buguruslanskaya St., 54. Holder of the registration certificate of LLC NPF MATERIA MEDIKA HOLDING, Russia. The name, the address and a contact information of the organization responsible for post-registration observation in the territory of RK: Representative office of LLC NPF MATERIA MEDIKA HOLDING in RK Almaty, Seyfullin St. 498, office 507. Ph./fax: 273 47 13 E-mail: kz@dep.materiamedica.ru the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products Representative office of LLC NPF MATERIA MEDIKA HOLDING in RK Almaty, Seyfullin St. 498, office 507.
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