Anthelmintic / Antiparasitics

Pyrantel 250 mg / 5 ml 15 ml of oral suspension

Brands: Medana (Poland)

$7.10

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Pyrantel 250 mg / 5 ml 15 ml of oral suspension quantity

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Brands:: Medana (Poland)

Description

The instruction for medical use of PYRANTELUM medicine the Trade name Pyrantelum the International not patent name Pyrantelum Dosage Form Suspension for intake, 250 mg / 5 ml Structure of 1 ml of suspension contains active agent – Pyrantelum of 50.000 mg (in the form of Pyrantelum of the embonat of 144.000 mg), excipients: Natrium benzoicum, sodium salt of the carboxylated methyl cellulose, sorbitol of 70%, glycerin, magnesium-aluminum silicate, polysorbate-80, povidone, simetikon an emulsion, citric acid monohydrate, sodium hydroxide, apricot aroma, water purified. The description Suspension of light yellow color with a characteristic smell. Division into a liquid layer and a deposit is allowed, after agitation uniform suspension is formed. Pharmacotherapeutic group Anthelminthic drugs. Tetragidropirimidina derivatives. Pyrantelum. The ATX P02 CC 01 code the Pharmacological Pyrantelum Pharmacokinetics properties embonat – is almost insoluble in water, and in insignificant degree is soaked up from a digestive tract, after reception of a single dose of 10 mg/kg of body weight, concentration of drug in blood plasma, makes 0.005 – 0.13 mkg/ml within 1-3 hours. About 7% are removed with urine in not changed form (0.2-1.6%) and partially in the form of metabolites (0.8-5.6%). It is metabolized in a liver, the main metabolite is N-methyl-1.3-propanodiamin. About 93% of the drug taken orally are removed in not changed look through intestines. The pharmacodynamics Pyrantelum is anthelminthic drug in infection intestinal round worms. Affects muscles of intestinal nematodes, by depolarization of their neuromuscular connection and blockade of effect of cholinesterase. Immovable parasites are brought from intestines thanks to peristaltic movements. Does not cause migration of helminths, does not possess irritant action. Affects mature forms and on parasites in an early stage of development and their migration in fabrics does not affect larvae in time. Drug is used first of all in infections with pinworms (Enterobius vermicularis) and ascarids (Ascaris lumbricoides). It can be applied in infection with a hookworm, has more effective effect at treatment of an ankilostomidoz, than at treatment of a necatoriasis. Indications – an enterobiosis – an ascaridosis – a dochmiasis – a necatoriasis the Route of administration and doses Inside in time or after a meal. In an enterobiosis and an ascaridosis (also at the mixed invasions these parasites): to adults and children – from rascheta10 body weight mg/kg, once. Depending on age and the body weight of the patient the following doses are applied: Age of the patient of ml Dose of drug, mg Children: from 6 months to 2 years of 2.5 ml 125 mg from 2 to 6 years of 5.0 ml 250 mg from 6 to 12 years of 10.0 ml 500 mg are more senior than 12 years and adults with body weight to 75 kg 15.0 ml 750 mg more than 75 kg 20.0 ml 1000 mg, adult with body weight, In an ascaridosis of 5 mg of Pyrantelum on 1 kg of body weight, once. In a dochmiasis the treatment is more long: 10 mg/kg of body weight a day within 3 days or 20 mg/kg of body weight a day within 2 days, once 5 ml of suspension (1 measure) – contain 250 mg of Pyrantelum. Before reception to stir up before receiving a uniform suspension. There is no need of use of depletive. In an enterobiosis all family is exposed to treatment. After passing of 14 days after use control parasitological researches are obligatory. Side effects Drug is usually well transferred. Seldom (& gt, 1/10,000, & lt, 1/1,000) – disturbances of appetite, nausea, vomiting, an abdominal pain, diarrhea – a headache, dizziness, drowsiness, insomnia – skin rash – an asthenia, increase in concentration of hepatic enzymes In isolated cases – tenesmus, hallucinations with a disorientation, paresthesia, fever, the Contraindication hearing disorder – hypersensitivity to drug components – simultaneous use of piperazin – the myasthenia (treatment period) Medicinal interactions Can increase concentration of theophylline in blood plasma. Pyrantelum should not be applied along with piperazin as these drugs are antagonists. Special instructions to apply Carefully at children up to 2 years, in the presence of anemia, at the exhausted patients and also in case of an abnormal liver function (causes temporary increase in level aspartattransaminazy). At treatment of an enterobiosis, all in common living persons at the same time have to be treated. Careful respect for hygiene (cleaning of premises and cleaning of clothes for destruction of eggs of helminths) serves as prevention of reinfection. Because drug contains sorbite solution, it should not be appointed to patients with rare heredity intolerance of fructose. Drug can have easy laxative effect. The period of pregnancy and a lactation of the Research on animals did not reveal negative impact of Pyrantelum on a fruit. However, owing to lack of controlled researches on use of Pyrantelum during pregnancy, it is necessary to appoint drug pregnant only if the expected advantage for mother exceeds potential risk for a fruit. Data on use of Pyrantelum for the feeding women is absent. Prescribing of Pyrantelum is not recommended to the women nursing. In need of use of drug in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination. Features of influence of medicine on ability to run the vehicle and potentially dangerous mechanisms of the Research of influence of drug on ability of driving of vehicles and service of the mechanical equipment it was not carried out. Overdose Symptoms: disorders of vision, a disorientation, dizziness, a faint or feeling of dizziness at rise from a prone position or sitting, the increased sweating, earlier not observed feeling of fatigue or weakness, irregular pulse, muscular spasms, a tremor and weakness, exhaustion, asphyxia (the complicated breath, a loss of consciousness). Treatment: specific antidote does not exist. In case of overdose it is necessary to take the symptomatic and supporting measures: gastric lavage, use of depletive, ensuring passability of airways and support of breath, support of level of arterial blood pressure. The form of release and packing On 15 ml of drug place in bottles of orange glass with covers from polyethylene. 1 bottle together with a measure with a scale and the instruction for use in the state and Russian languages is placed in a cardboard box. To Store storage conditions at a temperature not above 25 °C. To protect from light. To store out of children’s reach! 3 years the Period of storage after the first opening of packing – 21 days not to use a period of storage after an expiration date. Prescription status According to the prescription the Name and the country of the manufacturing organization of Medan JSC Pharm 98-200 Seradz, V. Loketk St. 10, Poland the Name and the country of the owner of the registration certificate of JSC Khimpharm, Kazakhstan the Name and the country of the organization packer of Medan JSC Pharm, Poland the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods) of JSC Khimpharm, Shymkent, Republic of Kazakhstan, Rashidov St., 81 Phone number 7252 (561342) Fax number 7252 (561342) the E-mail address of infomed@santo.kz

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