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Pilocarpine hydrochloride 10 ml of 1% eye drops




The instruction for use
of medicine for experts


the Trade name
of Pilocarpine a hydrochloride
the International unlicensed

name Pilocarpine Dosage Form
of the Drop eye 1%.
The structure
of 1 ml of solution contains
active agents – pilocarpine a hydrochloride of 0.01 g,
excipients: boric acid, water for injections.

Transparent, colourless liquid

Pharmacotherapeutic group
Protivoglaukomny means. Parasympathomimetics.
ATC S01E B01 code

the Pharmacological

Pharmacokinetics At properties of instillation in a conjunctival sac pilocarpine gets into eye environments where makes the specific impact. At use in therapeutic doses drug is practically not soaked up in a system blood stream. The inactivation of pilocarpine occurs presumably by removal by its lacrimal liquid and in nervous synapses.

The Pilocarpine pharmacodynamics a hydrochloride belongs to M-cholinomimetic means. The mechanism of action is caused by excitement peripheral M-holinoretseptorov that causes a number of specific effects, including narrowing of a pupil with simultaneous reduction of intraocular pressure and improvement of trophic processes in eye tissues.

· bad attack of glaucoma
· secondary glaucoma (as a result of thrombosis of the central vein of a retina, acute impassability of an artery of a retina, an atrophy of an optic nerve, a pigmentary degeneration of a retina, a vitreous hemorrhage)
· chronic open angle glaucoma
· cornea abscess
· for the termination of mydriatic action after the use of atropine and other cholinolytics which are applied to mydriasis at ophthalmologic inspection.

The route of administration and doses
of Pilocarpine dig in a hydrochloride in each eye on 1–2 drops 2–4 times a day. Time intervals between instillations and the number of the last and also duration of a course of treatment are defined by the doctor.

Side effects
· spasm of a tsiliarny muscle, eye pain
· short-term disorder of vision
· headache
· follicular conjunctivitis
· contact dermatitis a century (at prolonged use).

· an iritis, an iridocyclitis and other diseases of eyes in which the miosis closed-angle glaucoma is undesirable
· acute inflammatory diseases of tissues of eye
· bronchial asthma
· children’s, teenage and youthful age (up to 18 years).
· periods of pregnancy and lactation
· hypersensitivity to drug components.

Medicinal interactions
Atropine and other M-cholinolytic means are antagonists of Pilocarpine of a hydrochloride. At simultaneous use with other parasympathomimetics its pharmacological action amplifies.

Special instructions
Just before use it is necessary to take a bottle with drug in a palm to warm up the last to body temperature. The lid is unscrewed, removed, and, slightly pressing on the bottle body, dig in solution in an eye. After burying the lid is densely screwed up and store drug according to the recommendations provided in the instruction.
With an initial form of a cataract the miotic effect can cause a passing disorder of vision in patients. Drug treatment needs to be carried out at regular control of intraocular pressure.
Influence on ability to drive motor transport and to operate mechanisms
At strong narrowing of a pupil arises feeling of short-sightedness therefore drug use is not recommended to drivers of transport in evening and night time.
With care appoint to the persons occupied with driving of motor transport, etc. potentially dangerous types of activity requiring clear sight, special attention and high speed of response.

Symptoms: persistent miosis, eye pain, disorder of vision, headache. Treatment: drug is cancelled, carry out instillation of drugs antagonists – a tropikamid, atropine or other its derivatives.

Form of release and packing
On 5 ml or 10 ml in a bottle polyethylene, enclosed together with the instruction for use in a pack.

To Store storage conditions in the place protected from light, at a temperature from 8 °C to 15 °C. To store out of children’s reach!

The expiration date

After opening of a bottle drug is suitable 3 years 28 days. Drug should not be used after the termination of the expiration date specified on packing.

Prescription status
According to the prescription

JSC Pharmak Producer.
04080, Ukraine, Kiev, st. of Frunze, 63.

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