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On taxi-Forte 100 mg / 5 ml 32g powder for oral suspension

$19.30

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Brands:: Alkem (India)

Description

Taksim-O Forte

the Trade name
of Taksim-O Forte

the International unlicensed

name Tsefiksim Lekarstvennaya a form
Powder for preparation of suspension for intake of 100 mg / 5мл

Structure
of 5 ml of suspension contain
active agent – a tsefiksim (in the form of a tsefiksim of trihydrate) 100 mg
excipients: sucrose, xanthane gum, silicon dioxide colloidal, Natrium benzoicum, fragrance with taste of a lemon.

The description
the Loose granulated powder, almost white color. After dilution, water forms homogeneous suspension of almost white color with taste of a lemon.

Pharmacotherapeutic group
Antimicrobial drugs for system use.
Cephalosporins of the third generation.
The code of automatic telephone exchange J01DD08

the Pharmacological

Pharmacokinetics Absorption Later properties of intake is soaked up by tsefiksy for 40-50%, irrespective of meal. Peak plasma concentration are reached in 2-6 hours after oral administration.
Distribution
of Data on distribution of a tsefiksim in body tissues are limited. Drug passes through a placenta. Rather high concentrations can be reached in bile and urine.
Metobolizim and removal
Tsefiksim is generally brought in not changed look about 50% within 24 hours with urine, about 10% are removed with bile. Linking with proteins of serum makes about 65%.
Elimination half-life 2-4 hours. Elimination half-life does not depend on a dose of a form and increases at patients with a renal failure.
The pharmacodynamics
of Taksim-O Forte has bactericidal effect due to suppression of synthesis of cell walls of a bacterium. Taksim-O Forte has high resistance to action beta laktamaz.
Taksim-O it is Forte active concerning the majority of strains of the following microorganisms:
Gram-positive microorganisms: Streptococcus pneumonia, Streptococcus pyogenes, Streptococcus agalactiae
Gram-negative microorganisms: Haemophilus influenza (the strains which are producing and not producing some beta lactamazu), Moraxella (Branhamella) catarrhalis (the majority of which produces beta laktazmu), Escherichia coli, Proteus mirabilis, Neisseria gonorrhoeae (including the strains which are producing and not producing penicillinase), Haemophilus parainfluenzae (the strains which are producing and not producing a betalaktazma), Proteus vulgaris, Klebsiella pneumonia, Klebsiella oxytoca, Pasteurella multocida, Providencia spp., Salmonella spp., Shigella spp., Citrobacter amalonaticus., Citrobacter diversus., Serratia marcescens.

Indications
– average otitis, pharyngitis, tonsillitis
– an acute bronchitis, exacerbation of chronic bronchitis
– uncomplicated infections of urinary tract
– out-patient treatment of uncomplicated gonorrhea (urethra and a neck of the uterus)

the Route of administration and doses
to Adults and children are more senior than 12 years with body weight more than 50 kg: 400 mg daily in the form of a single dose or on 200 mg 2 times a day.
In uncomplicated gonorrhea of an urethra and neck of the uterus the single oral dose of 400 mg is appointed.

Children:
The recommended dose of suspension makes 8 mg/kg a day. It can be applied in a daily dose once or in 2 receptions, that is 4 mg/kg each 12 hours.

The weight of the patient
(kg)

the Daily dose

the Daily dose
(teaspoons)

(mg)

(ml)

6.25

50 2.5 0.5 12.5 100 5.0 1.0 18.75 150 7.5 1.5 25 200 10.0 2.0
Single dose for children up to 12 years of 4-8 mg/kg, daily 8 mg/kg of weight.
The average duration of a course of treatment is 7-10 days.
Instructions on suspension preparation:
In a bottle to add svezhekipyacheny chilled water to dry powder, it is good to shake up for full dissolution. Again to add water to the lower bound of a tag on a bottle to add volume to 30 ml. Suspension should be used within 4 days after preparation. Before the use to shake up.
A dosage in a renal failure:
– to Patients with clearance of creatinine from 21 to 60 ml/min. and to the patients who are on a renal hemodialysis appoint 75% of a standard dose with observance of a standard interval.
– To patients with clearance of creatinine less 20ml/mines and to the patients who are on long peritoneal dialysis appoint a half of a standard dose with observance of a standard interval.

Side effects
– anorexia, dryness in a mouth, diarrhea, an abdominal pain, nausea, dyspepsia, a meteorism, increase in liver enzymes, jaundice
– the excess growth of steady microorganisms, candidiasis – pseudomembranous colitis
– an acute anaphylaxis, a small tortoiseshell, a dermahemia, a skin itching, an itching in genitals, an eosinophilia, fever, a multiformny exudative erythema (including Stephens-Johnson’s syndrome), a toxic epidermal necrolysis (Lyell’s disease)
– an abnormal liver function, a cholestasia
– a renal failure, a toxic nephropathy, interstitial nephrite
– aplastic anemia, hemolytic anemia, hemorrhages, a leukopenia, thrombocytopenia, an agranulocytosis
– spasms, dizzinesses,

the Contraindication headache
– hypersensitivity to cephalosporins, penicillin and other components of drug
– children’s age up to 6 months
– nonspecific ulcer colitis

Medicinal interactions
the patients receiving anticoagulants as can extend with tsefiksy a prothrombin time Should be careful when assigning a tsefiksim. Antacids, compounds of magnesium or aluminum of hydroxide slow down absorptions of a tsefiksim.

Special instructions
the Renal failure
At patients with a renal failure and also being on long out-patient peritoneal dialysis or a hemodialysis it is necessary to adjust a dose of a tsefiksim and to provide strict observation.
Pregnancy and the period of a lactation
Tsefiksim are appointed during pregnancy only in urgent cases.
It is unknown whether drug with breast milk is emitted. In need of treatment tsefiksimy it is necessary to stop breastfeeding temporarily.
Influence of medicine on ability to drive the car or potentially dangerous mechanisms
was not reported to feature About influence

Overdose
Symptoms: diarrhea, liquid or frequent chair, abdominal pain, nausea, dyspepsia, meteorism, excess growth of steady microorganisms, pseudomembranous colitis, acute anaphylaxis, toxic, epidermal necrolysis, superinfection, disturbance of functions of kidneys, toxic nephropathy, abnormal liver function, cholestasia, aplastic anemia, hemolytic anemia, hemorrhages, spasms.
Treatment: symptomatic.

A form of release and packing
On 32 g in the bottles of orange glass corked by the screwing-up aluminum cover. The dosing cap from PVC is applied to a bottle.
On 1 bottle together with the instruction for medical use in the state and Russian languages place in a pack from cardboard.

To Store storage conditions in the dry, protected from light place, at a temperature not above 25 °C. After preparation to use within no more than 7 days.
To store drug out of children’s reach!

2 years
not to use a period of storage after an expiration date.

Prescription status
According to the prescription

Alkem Laboratories Ltd Mumbai Producer – 400,013, India

Additional information

Ingredient

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