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NAZOFERON NASAL SPRAY (INTERFERON ALFA-2B 100000 IU/ML) 5 ml

$18.50

nazoferon5mlspray

Description

1 ml of the drug contains the active substance – recombinant human interferon alfa-2 b not less than 100,000 IU,

Excipients: trometamol, trometamol hydrochloride, hypromelose, disodium edetate, lysine hydrochloride, potassium chloride, methyl parahydroxybenzoate, water for injection.

NAZOFERON is an antiviral, anti-inflammatory, immunomodulatory, antiproliferative agent. The mechanism of antiviral action is to inhibit the replication of viruses (adenoviruses, influenza viruses, etc.) due to the inhibitory effect on the processes of transcription and translation; antiproliferative – inhibits cell reproduction (most DNA and RNA viruses). Interferon initiates the synthesis of a specific enzyme – protein kinase, which prevents translation due to the phosphorylation of one of the initiating factors of this process; activates a specific ribonuclease, which damages the messenger RNA of the virus. The effects of interferon also include: stimulation of the production of other cytokines, induction of specific enzymes, inhibition of cell proliferation, immunomodulation (increased phagocytic activity of macrophages and specific cytotoxicity of lymphocytes in relation to target cells). Interferon is an immune mediator and has a pronounced tissue specificity. Due to its effects, interferon protects the body from pathogens of infectious diseases (viruses, bacteria, mycoplasmas, pathogenic fungi, etc.).

 

Indications for use

Prevention and treatment of SARS, colds:

in children from 1 year and adults;

in patients with frequent and long-term illnesses of the upper respiratory tract;

with a seasonal increase in the incidence in organized groups (children and adults), among the “risk” contingents – medical workers, teachers, etc., especially during the epidemic.

 

Dosage and administration

At the first signs of ARVI disease (within 5 days)

Children from 1 to 3 years old – 2 spray doses in each nasal passage 3-4 times a day (single dose – 20,000 IU, daily dose: – 60,000-80,000 IU);

Children from 3 to 14 years old – 2 spray doses 4-5 times a day (single dose – 20,000 IU, daily dose – 80,000-100,000 IU);

Adults – 3 spray doses 5-6 times a day (single dose – 30,000 IU, daily dose – 150,000-180,000 IU).

For the prevention of respiratory viral infections

In contact with the patient and in case of hypothermia – in accordance with the age dosage 2 times a day for 5-7 days. If necessary, preventive courses are repeated. With a single contact, one injection is sufficient.

With a seasonal increase in the incidence – in accordance with the age dosage once in the morning with an interval of 1-2 days.

 

Side effects

In isolated cases:

rash on the skin
dryness of the mucous membranes of the nasal passages

 

Contraindications

hypersensitivity to interferon alfa-2b and other components that make up the drug

severe forms of allergic diseases in history.

 

Drug Interactions

When using the drug NAZOFERON in uncomplicated cases, no additional symptomatic treatment is required (paracetamol, sulfonamides, vasoconstrictor nasal drops). At elevated body temperature, the drug is combined with anti-inflammatory drugs. The simultaneous use of intranasal vasoconstrictor drugs is not recommended, since they contribute to the drying of the nasal mucosa.

Scheme of using a nasal spray:

Do not use the drug in case of violation of the integrity and labeling of the package, with a change in physical properties (color or transparency of the liquid) and after the expiration date.

Application in pediatrics

The drug is used for children from 1 year.

Use during pregnancy and lactation

There are no data on the use of NAZOFERON in pregnant and lactating women.

Features of the effect of the drug on the ability to drive vehicles and potentially dangerous mechanisms

Does not affect.

 

Storage conditions

To store in the place protected from light at a temperature from 2 to 8 °C.

Keep out of the reach of children!

Shelf life – 2 years
Shelf life after opening the vial is 10 days.
Do not use the drug after the expiration date indicated on the package.

Additional information

Ingredient

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