Anesthetics, Muscle relaxants / Painkillers and Antispasmodics

Muskomed 4 mg / 2 ml injection 6’s

Brands: Mefar Ilach San.Ve Tidzh.A.Sh. (Turkey)

$28.60

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Muskomed 4 mg / 2 ml injection 6's quantity

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Brands:: Mefar Ilach San.Ve Tidzh.A.Sh. (Turkey)

Description

The instruction for medical use of MUSKOMED medicine the Trade name Muskomed Mezhdunarodnoye the unlicensed name Tiokolkhikozid Lekarstvennaya a form Solution for injections of 4 mg / 2 ml, 2 ml Structure 1 ampoule contains active agent: tiokolkhikozida of 4 mg, excipients: chloride sodium, acid chlorohydrogen, water for injections. Description Transparent solution of light yellow color Pharmacotherapeutic group Muscle relaxants of the central action others. Tiokolkhikozid. The ATX M03BX05 code the Pharmacological Pharmacokinetics At properties intramuscular introduction tiokolkhikozid is quickly distributed in blood, the peak of concentration in plasma is reached in 15-45 minutes. After one intramuscular injection in a dose of a tiokolkhikozid of 4 mg the maximum concentration in plasma makes 61 ng/ml. Linking with proteins (generally with albumine) makes 13%. The average seeming distribution volume – 76 l after one intramuscular injection in a dose of 4 mg. Elimination half-life makes 2.5-5 hours. About 20% of the accepted dose are excreted with urine in the form of not changed metabolites, 75-81% are removed with excrements. The pharmacodynamics Muskomed is semi-synthetic substance of natural pseudo-alkaloid of colchicine and sulfur. Has myorelaxation effect (muscular relaxant). Tiokolkhikozid contacts only GAMK and the glitsinergichesky receptors sensitive to strychnine in in-vitro researches. Tiokolkhikozid acting as the antagonist of the GAMK-receptor can have the effective myorelaxation effect by means of regulatory complex mechanisms at the supraspinal level, however, its glitsinergichesky mechanisms of action cannot be excluded. Characteristics of interaction of a tiokolkhikozid with GAMK receptors, same, as well as with derivative a glucuronide which is the main metabolite in a blood-groove in high-quality and quantitative expression. Myorelaxation characteristics of a tiokolkhikozid and its main metabolite were shown in several experimental models which are carried out by in Vivo. The lack of myorelaxation effect of a tiokolkhikozid shows that this connection has prepotent supraspinal action. Also, elektroentsefalografichesky researches showed that tiokolkhikozid and its main metabolite do not cause sedation. Indications – symptomatic treatment of painful muscular spasms. The route of administration and doses Muskomed apply intramusculary 2 ml (4 mg) 2 times a day. It is not recommended for long-term treatment of chronic diseases. The recommended term of treatment of 3 – 5 days. By preparation for physiotherapeutic procedures the period of relaxation of muscles is 30-40 minutes after an intramuscular injection. Side effects Seldom: – disturbances from nervous system (drowsiness, confusion of consciousness, excitement) – disturbances from digestive tract (diarrhea, a gastralgia, nausea) – disturbance of activity of a cardiovascular system (hypotension) – disturbances from the immune system (allergic rash, anaphylactic reactions, including a Quincke’s disease) – allergic skin reactions Very seldom: – reaction of an anaphylaxis, including an acute anaphylaxis of the Contraindication – supersensitivity to a tiokolkhikozid or auxiliary components of drug – a flaccid paralysis and a hypomyotonia – therapy by anticoagulants and predisposition to hemorrhages – pregnancy and the period of a lactation – children’s age up to 18 years the Medicinal interactions of Data on medicinal interaction are not present. However it is recommended to be careful at a concomitant use with other muscle relaxants. At simultaneous use with the drugs oppressing the central nervous system including with alcohol, antihypertensive drugs, kurarepodobny drugs strengthening of muscle relaxation and oppression of central nervous system, development of hypotonia is possible. At simultaneous use with anticoagulants the risk of bleedings increases. The special instructions Muskomed should be applied with care at impaired renal function or a liver. To take at patients with allergic reactions in the anamnesis with caution. Tiokolkhikozid can cause epileptic attacks in the patients having epilepsy or entering into risk group. Safety and efficiency of use Muskomeda was not studied for the patients having a renal or liver failure and also for elderly patients. For these patients, especially advanced age, low doses of drug are recommended. Influence on reproductive function: Though metabolites of drug have anogenic activity, drug does not affect reproductive function. Metabolites of drug can have undesirable effect on male fertility and, therefore, use of drug it is not recommended at men with problems in the relation and it is necessary to consider the possibility of drug withdrawal. After new experimental data which assumed that tiokolkhikozid it was broken in an organism in a metabolite called M2 or SL59.0955 that can lead the sharing cells to damage therefore an aneuploidy (abnormal number or arrangement of chromosomes). The aneuploidy is risk factor for harm for the developing fruit, decrease in fertility at men and in the theory can increase risk of developing cancer. The feature of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms during treatment needs to be careful during the driving of motor transport and occupation other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions. Overdose Symptoms: strengthening of side effects is possible. Treatment: symptomatic and maintenance therapy. The form of release and packing On 2 ml of drug spill in ampoules from colourless glass. On 6 ampoules place in blister strip packaging. On 1 planimetric packing together with the instruction for medical use in the state and Russian languages put in a pack from cardboard. To Store storage conditions at a temperature not above 25 °C. To store out of children’s reach! 3 years not to apply a period of storage after an expiration date. Prescription status According to the prescription the Owner of a trademark and the certificate of registration is the company UORLD of ILACh DIGNITY MEDICINE. VE TIDZh. A.Sh., TURKEY Producer A.Sh. Mefar Ilach Sanayii, Turkey (Ramazanolu Makh. Ensar Dzhad. No. 20, 34906 Kurtkyoy-Pendik / Istanbul) Owner of the registration certificate UORLD of ILACh DIGNITY MEDICINE. VE TIDZh. A.Sh., TURKEY

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