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Antiseptic and disinfectant / Dermatology

Miramistin-A 0.01 ml 50% topical solution

Brands: Darnitsa (Ukraine)

$16.10

Out of stock

Sku:

5a8fe076e849

Brands:: Darnitsa (Ukraine)

Description

The instruction for medical use of MIRAMISTIN-A medicine the Trade name of MIRAMISTIN-A the International unlicensed name Is not present the Dosage form Solution for external use of 0.01%, 50 ml Structure of 1 ml of solution active agent – miramistin contains 0.1 mg excipient – the water purified. The description Colourless or with a yellowish shade the transparent liquid foaming when stirring. Pharmacotherapeutic Dermatology group. Antiseptic agents and disinfecting drugs. Quarternary ammonium connections. The ATX D08AJ code the Pharmacological Pharmacokinetics At properties external and topical administration miramistin has no ability to be soaked up through skin and mucous membranes. The pharmacodynamics is the cornerstone of action of a miramistin the direct hydrophobic interaction of a molecule with lipids of membranes of microorganisms leading to their fragmentation and destruction. At the same time a part of a molecule of a miramistin, plunging into the hydrophobic site of a membrane, destroys a nadmembranny layer, loosens a membrane, increases its permeability for high-molecular substances, changes fermental activity of a microbic cell, inhibiting fermental systems that leads to oppression of activity of microorganisms and their cytolysis. Unlike other antiseptic agents, miramistin has sharp selectivity of action concerning microorganisms since practically does not affect covers of cells of the person. This effect is connected with other structure of cellular membranes of the person (considerable the bigger length of the lipidic radicals which are sharply limiting a possibility of hydrophobic interaction of a miramistin with cells). Miramistin possesses the significant antimicrobic action concerning gram-positive and gram-negative, aerobic and anaerobic, spore-forming and asporogenic bacteria in the form of monocultures and microbic associations, including hospital strains. Works on causative agents of diseases, sexually transmitted: gonokokk, pale treponemas, trichomonads, chlamydias and also on viruses of herpes, an immunodeficiency of the person. Has antifungal effect on ascomycetes of the sort Aspergillus and the sort Penicillium, barmy (Rhodotorula rubra, Torulopsis gabrata) and yeast-like (Candida albicans, Candida tropicalis, Candida krusei) mushrooms, on dermatophytes (Trichophyton rubrum, Trichophyton mentagrophytes, Trichophyton verrucosum, Trichophyton schoenleini, Trichophyton violaceum, Epidermophyton Kaufman-Wolf, Epidermophyton floccosum, Microsporum gypseum, Microsporum canis) and also on other pathogenic fungi (for example Pityrosporum orbiculare (Malassezia furfur)) in the form of monocultures and microbic associations. Under the influence of a miramistin the resistance of microorganisms to antibiotics decreases. Indications Prevention and treatment as a part of complex therapy: – purulent wounds, pyoinflammatory processes of the musculoskeletal system in surgery and traumatology – postnatal injuries, wounds of a crotch and vagina with suppurations, postnatal infections, inflammatory diseases (vulvovaginitis, an endometritis) in obstetrics and gynecology – superficial and deep burns of II and IIIA of degree, preparation of burn wounds for dermatoplasty in Combustiology – a pyoderma and dermatomycoses, candidiases of skin and mucous membranes, mycoses of feet in dermatology – gonorrhoeas, clamidiosis, trichomoniasis, genital herpes, genital candidiasis in venereology – uretrit and uretroprostatit specific (clamidiosis, trichomoniasis, gonorrhea) and the nonspecific nature in urology – acute and chronic otitises, antritises, tonsillitis, laryngitis in otorhinolaryngology – stomatitises, ulites, parodontit, periodontitis and hygienic processing of removable prostheses in stomatology to Apply the Route of administration and doses locally adult. Surgery, traumatology, Combustiology. With the preventive and medical purpose of Miramistinom-A to irrigate a surface of wounds and burns, rykhlo to tampon a wound and the fistular courses, to fix the gauze tampons moistened with an antiseptic agent. To repeat the medical procedure 2-3 times a day for 3-5 days. The method of active drainage of wounds and cavities with a daily expense about 1 l of medicine is effective. Obstetrics and gynecology. For the purpose of prevention of a postnatal infection to apply in the form of vaginal irrigations before childbirth (5-7 days) and in the form of the intra vulval pads moistened with 50 ml of medicine, after the delivery with exposure of 2 h for 5 days. To carry out treatment of inflammatory diseases of female genitals by intra vaginal introduction of tampons with medicine for 2 weeks, processings of skin of external genitals and also a medicine electrophoresis. Dermatology. To perform treatment of candidiases of skin and mucous membranes, mycoses of feet and big folds by irrigation by means of a raspylitelny nozzle, 3-4 multiple pressing or appliques 2-4 times a day. Venereology. For individual prevention of diseases which are transmitted sexually solution of a miramistin is effective if to apply it no later than 2 hours after sexual intercourse. To enter bottle contents by means of an urethral nozzle into an urethra – to 2-3 ml (men), 1-2 ml (women), into a vagina – 5-10 ml for 2-3 minutes. After the procedure the bladder emptying for 2 hours is not recommended. To process leather of an internal surface of hips, a pubis, external genitals. Otorhinolaryngology. In purulent antritises during a puncture a genyantrum to wash out 10 ml of medicine. At treatment of tonsillitis and laryngitis to carry out reusable rinsings of a throat by Miramistin-A solution. In otitises to enter the tampon moistened with medicine into external acoustical pass of 4-6 times a day for 10-14 days. Stomatology. At treatment of parodontit, solution of a miramistin is entered into parodontalny pockets on turundas with the subsequent appliques on gums for 15 minutes. At aggravations to carry out washing of Miramistinom-A of parodontalny pockets by means of the syringe and to enter into a turunda abscess cavity with medicine. After carrying out a vestibuloplastika and a frenulektomiya to apply medicine in the form of baths in out-patient conditions. For the purpose of hygienic processing of removable prostheses to leave the last for the night in solution of a miramistin, before use carefully to wash prostheses with flowing water. Children. As there is no sufficient experience of use of solution of a miramistin for treatment of children, it should not be applied in pediatric practice. Side effects In some cases perhaps short-term burning sensation which is disappearing independently in 15-20 seconds and not demanding medicine cancellation. Reactions of hypersensitivity, including phenomenon of local irritation of skin: itching, hyperaemia, burning sensation, xeroderma. Contraindications Individual sensitivity to a miramistin. Medicinal interactions At the combined use of antibiotics with miramistiny the decrease in resistance of microorganisms to antibiotics is observed. Special instructions Venereology. After processing of Miramistinom-A of an urethra, a vagina, the internal surfaces of hips, a pubis and external genitals the urination within 2 hours is not recommended. Use during pregnancy or a lactation. As the medicine resorption is practically absent, use of Miramistin-A during pregnancy or feeding is allowed by a breast. Features of influence of medicine on ability to run vehicles or potentially dangerous mechanisms Use of medicine is characterized by lack of influence on ability to run motor transport or to be engaged in other potentially dangerous types of activity demanding the increased concentration of attention and speed of psychomotor reactions. Overdose Cases of overdose were not observed. A form of release and packing On 50 ml of drug in bottles polymeric. On bottles paste the label from paper with a self-adhesive covering. On 1 bottle with an urethral nozzle together with the instruction for medical use in the state and Russian languages place in a pack. It is allowed to place in addition in a pack information for patients on use of a bottle with a nozzle. To Store storage conditions in original packing at a temperature not above 25 °C. Not to freeze. To store out of children’s reach. 3 years not to apply a period of storage after an expiration date. Prescription status Without prescription CIAO Producer “Pharmaceutical Darnitsa. Ukraine, 02093, Kiev, Borispolskaya St., 13. The holder of the registration certificate of Alyce Pharm LLP, the Republic of Kazakhstan the Name, the address and a contact information (phone, the fax, e-mail) of the organization in the territory of the Republic of Kazakhstan, the accepting claim (offer) on quality of medicines from consumers: Alyce Pharm LLP, Republic of Kazakhstan, 050000, Almaty, Topolevskaya St., 157K ph./fax: +7 (727) 246 70 94 el. address: ip_samenova.mk@mail.ru the Name, the address and a contact information (phone, the fax, e-mail) of the organization in the territory of the Republic of Kazakhstan responsible for post-registration observation of safety of medicine: Alyce Pharm LLP, Republic of Kazakhstan, 050000, Almaty, Topolevskaya St., 157K ph./fax: +7 (727) 246 70 94 el. address:
To Develop ip_samenova.mk@mail.ru