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Makmiror 200 mg (20 tablets)




The instruction for medical use

of MAKMIROR medicine

the Trade name

of the drug Makmiror Mezhdunarodnoye the unlicensed

name Nifuratel Lekarstvennaya

the Tablet form, coated, 200 mg


One tablet contains

active agent nifuratet 200 mg,

excipients: starch corn, starch rice, polyethyleneglycol 6000, talc, magnesium stearate, gelatin, arabic gum, sucrose, magnesium carbonate, titan dioxide (E 171), E-wax.


Biconvex tablets, coated, white color.

Pharmacotherapeutic group

of Antiseptics and antimicrobial drugs for treatment of gynecologic diseases. Antiseptic agents and antimicrobial drugs for treatment of gynecologic diseases (excepting combinations with corticosteroids). Other antiseptic agents and antimicrobial drugs. Nifuratel.

ATX G01AX05 code

Pharmacological action


At intake is quickly absorbed from digestive tract. At single dose in a dose of 200 mg the peak of serumal concentration (9.48 mg/l) is reached in 2 hours and so quickly brought out of an organism (the half-life period is equal to 2 hours 45 minutes). Nifuratel has high bioavailability (& gt, 95%). Gets through a blood-brain and gematoplatsentarny barrier, it is allocated with breast milk. It is metabolized in a liver and muscle tissue.

It is completely brought out of an organism by kidneys (30-50% – in not changed look).

The pharmacodynamics

Nifuratel, derivative nitrofuran, is synthetic antibacterial drug of a broad spectrum of activity. Drug highly – is effective concerning bacterial, protozoan and fungal activators. The mechanism of action is caused by blockade of process of polymerization of a peptide chain and, therefore, suppression of synthesis of DNA in bacterial cells, sensitive to drug. The inhibition of synthesis of protein in ribosomes of a bacterial cell occurs due to irreversible linking with S30 and S50 subunits of ribosomes therefore process of forming of all peptide chain is broken.

Besides, there are data that nifuratet has also bactericidal effect. The mechanism of such action is connected with recovery of nitrogroup in an amino group. Got into condition block transport of electrons in a microbic cell, cause mutations and a rupture of DNA, oxidize the fermental systems of microorganisms.

It is highly effective concerning Papiliobacter and Helicobacter pylori, gram-positive and gram-negative microorganisms: at the minimum overwhelming concentration (MOC) of 12.5 – 25 mkg/ml suppresses from 44.3 to 93.2% of cultures.

The spectrum of action includes: Enterococcus faecalis, Enterococcus faecium, Staphylococcus aureus, Bacillus subtilis, Escherichia coli, Shigella flexneri 2a, Shigella flexneri 6, Shigella sonnei, Salmonella typhi, Salmonella typhimurium, Salmonella enteridis, Klebsiella spp., Enterobacter sph., Serratia spp., Citrobacter spp., Morganella spp., Rettgerella spp., Pragia fontium, Budvicia aquatica, Rachnella aquatilis and Acinetobacter spp., other atypical enterobakteriya and also protozoa, (amoebas, lyambliya), is less active concerning Proteus mirabilis, Proteus vulgaris, Prseudomonas aeruginosa.

Is choice drug for therapy of salmonelloses, shigelloses, etc. intestinal bacterial infections. It is active concerning Trichomonas vaginalis, is highly active concerning sort Candida mushrooms. It is especially effective concerning strains of Helicobacter pylori resistant to metronidazole.


as a part of complex therapy:

– the vulvovaginal infections caused by activators, sensitive to drug (pathogenic microorganisms, Candida, trichomonads, yeast-like mushrooms, bacteria, chlamydias)

– pyelonephritis, an urethritis, cystitis, a pyelitis and other diseases of an urinary system

– an intestinal amebiasis and a giardiasis

– the chronic inflammatory diseases of upper parts of digestive tract caused by Helicobacter pilory.

The route of administration and doses

take the Drug inside, following recommendations.

Vaginal infections:

Adults: 1 tablet 3 times a day after a meal within 7 days (both sexual partners have to take the drug)

Children since 6 years: the recommended dose of 10 mg/kg of body weight daily within 10 days. The recommended dose has to be accepted in two steps.

Infections of urinary tract:

Adults: depending on weight of a course of the disease of 3-6 tablets after meal daily within 7-14 days.

Children since 6 years: the recommended dose of 30-60 mg/kg of body weight. The recommended dose has to be accepted in two steps.

According to the recommendation of the doctor the course of treatment of infections of urinary tract can be prolonged or repeated.

Intestinal amebiasis:

Adults: 2 tablets 2-3 times a day within 10 days.

Children since 6 years: the recommended dose of 10 mg/kg of body weight 3 times a day.


Adults: 2 tablets 2-3 times a day within 7 days.

Children since 6 years: the recommended dose – 15 mg/kg of body weight 2 times a day within 7 days.

The GIT infections associated with Helicobacter pylori:

Adults: 2 tablets 2-3 times a day within 7 days.

Children since 6 years: the recommended dose of 15 mg/body weight 2 times a day within 7 days.

Side effects

– nausea, vomiting, bitterness in a mouth, diarrhea, heartburn, a gastralgia

– skin rash, an itching.


– hypersensitivity to active agent or any component of drug

– the children’s age up to 6 years

Medicinal interactions

Strengthens fungicide effect of nystatin.

Special instructions

need to be carried out simultaneous treatment of the sexual partner because of danger of repeated infection. At treatment of vaginal infections only performing oral therapy by the drug Makmiror recommends to increase a day dosage to 4 – 6 tablets.

During treatment it is necessary to refrain from sexual contacts or to apply in addition Makmiror before each sexual intercourse.

In order to avoid strengthening of side effects it is not recommended to apply alcoholic beverages during the therapy period the drug Makmiror. Use at pregnancy and a lactation

Nifuratel gets through a blood-brain barrier therefore use of drug is possible only according to strict indications if the expected effect of therapy exceeds potential risk for a fruit.

Nifuratel is excreted in breast milk therefore in need of prescribing of drug in the period of a lactation it is necessary to resolve an issue of the breastfeeding termination.

The feature of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms

of Negative effect is not revealed.


of Cases of overdose it is noted.

The form of release and packing

On 10 tablets pack into blister strip packaging from PVC of a film and aluminum foil.

On 2 blister strip packagings together with the instruction for use in the Russian and state languages place in a cardboard pack.

To Store storage conditions at a temperature not over 25 With in the place protected from light. To store out of children’s reach!

Not to apply a period of storage of 5 years after expiry date.

Prescription status

According to the prescription

the Producer Doppel Pharmatseutitsi of Neuter of l., Italy

The owner of the registration certificate

Polikem of Neuter of l., Italy

the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods)

05051, Almaty, Dostyk Ave. 105, phone number / fax +7 (727) 3171464


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