Angina pectoris / Cardiovascular System

Kordiamin 25% / 2 ml 10s solution for injection in ampoules

Brands: Darnitsa (Ukraine)

$5.90

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Kordiamin 25% / 2 ml 10s solution for injection in ampoules quantity

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Brands:: Darnitsa (Ukraine)

Description

The instruction for medical use

of KORDIAMIN-DARNITSA medicine

the Trade name

Kordiamin-Darnitsa

the International unlicensed

name Nikethamidum Dosage Form Solution for injections of 25% 2 ml

Structure

of 1 ml of solution contains

active agent – Nikethamidum of 250 mg

excipient – water for injections

the Description

Transparent, colourless or slightly yellowish color solution with a characteristic smell

Pharmacotherapeutic group

Other drugs for treatment of diseases of respiratory organs. Stimulators of a respiratory center. Nikethamidum.

The ATX R07A B02 code

the Pharmacological

Pharmacokinetics Kordiamin-Darnitsa properties is well absorbed in blood at all methods of administration, rather quickly collapses, works not for long (15-60 minutes). In an organism it is metabolized in a liver with formation of niacinamide, monoethylamide of niacin, Nikethamidum-N-oxide. It is quickly removed with urine in the form of inactive metabolites.

A pharmacodynamics

the Analeptic of the mixed action type. The mechanism of action consists of two components: central and peripheral. The first, connected with direct influence on a vasomotor center of a medulla also leads to its arousing and mediate increase in system arterial blood pressure (especially at primary oppression of this center). The peripheral component is connected with excitement of chemoceptors of a carotid sine and leads to increase in frequency and depth of respiratory movements. At intravenous administration of drug the rhythm accelerates, the frequency and depth of breath increases, slightly and quickly arterial blood pressure increases. Drug has no direct stimulating impact on heart and does not show the direct stimulating vasoconstrictive effect.

Indications

– collapse and asphyxia (including asphyxia of newborns)

– shock states at surgeries and during the postoperative period

– acute and chronic disorders of blood circulation

– decrease in a tone of vessels

– weakening of breath in infectious diseases and during recovery

– poisoning with sleeping and analgetic medicines (as a part of complex therapy)

the Route of administration and doses

Single and daily doses, frequency of introduction are established individually by the doctor depending on indications and age of the patient.

The drug is administered subcutaneously, intramusculary and intravenously. To adults and children 14 years are more senior appoint 12 ml of the 13th time a day.

For intravenous administration a single dose of drug dissolve 0.9% of solution of sodium of chloride in 10 ml, enter in 13 min.

the Highest doses for adults subcutaneously: single 2 ml, daily 6 ml. The highest single dose subcutaneously and intravenously in poisonings for adult 5 ml.

To children appoint subcutaneously, depending on age, such single doses:

till 1 year of 0.1 ml,

the 14th year of 0,150,25 ml,

56 years of 0.3 ml,

79 years of 0.5 ml,

1014 of 0.75 ml.

Enter 13th once a day.

Side effects

– concern, acrimony, uneasiness

– nausea, vomiting

– arrhythmias, arterial hypertension, tachycardia

– muscular twitchings which begin with circular muscles of a mouth, a tremor, muscle tension

– reddening, pastosity of the person, an itching of skin, peeling of skin

– a hyperthermia, the increased perspiration

– allergic reactions: reactions of hypersensitivity, urticaria, a Quincke’s disease, generalized papular rashes

– reactions in the injection site: infiltration and morbidity in the injection site

of the Contraindication

– hypersensitivity to Cordiaminum or to any of drug components

– predisposition to spasms, epilepsy, epileptic seizures (in the anamnesis)

– a porphyria

– a hyperthermia at children

– pregnancy and the period of feeding by a breast

Medicinal interactions

Analeptical action of Kordiamin-Darnits decreases under the influence of PASK, Saluzidum, derivatives of a fenotiazin (aminazine, etc.). Aminazine and reserpine can strengthen convulsive action of Kordiamin-Darnits. The pressor effect of drug increases under the influence of MAO inhibitors. Kordiamin-Darnitsa contributes to the development of intolerance of Ftivazidum. Enhances effects of psychostimulants, antidepressants. Reduces action of narcotic analgetik, sleeping, antipsychotic medicines, anxiolytics, anticonvulsants.

Against the background of a deep anesthesia Kordiamin-Darnitsa does not act.

Drug is inactivated by acids and alkalis. Not to mix with other medicines. To use only the recommended solvent.

Special instructions

use Drug only under observation of the doctor in stationary conditions. At intravenous administration works quickly. As subcutaneous and intramuscular injections of Kordiamin-Darnits painful, for easing of pain in the place of an injection (depending on a situation) enter novocaine (adult 1 ml of 0.5% of solution) in advance.

Children

Drug is used in pediatric practice in the recommended age doses. Use at a hyperthermia is contraindicated.

Pregnancy and the period of a lactation

Drug is contraindicated at pregnancy and during feeding by a breast.

The feature of influence of medicine on ability to run motor transport and especially dangerous mechanisms

during treatment needs to avoid control of motor transport and performance of potentially dangerous types of activity connected with need of concentration of attention and the increased speed of psychomotor reactions.

Overdose

Symptoms: in high doses drug can cause generalized toniko-clonic spasms, development of disturbances of consciousness and breath, an apnoea during spasms, the lethal outcome is not excluded.

Treatment. Use of anticonvulsants, if necessary the managed breath. Artificial diuresis.

A form of release and packing

On 2 ml in ampoules glass.

It is allowed to paste on an ampoule the label from paper with a self-adhesive covering or to put with paint of an intaglio printing for glass products.

On 10 ampoules together with the instruction for medical use in the state and Russian languages and a knife for opening of ampoules put in a box cardboard with a corrugated insert from paper for corrugation.

When packing ampoules with a color ring of a break or with a color point of a break, laying of knives for opening of ampoules is excluded.

Boxes paste over with the label parcel post from paper label or papers offset.

Packing of boxes together with the corresponding number of instructions for medical use in the state and Russian languages in group packing is allowed.

On 5 ampoules together with a knife for opening of ampoules place in blister strip packaging.

On the 2nd blister strip packagings together with the instruction for medical use in the state and Russian languages place in a pack cardboard.

When packing ampoules with a color ring of a break or with a color point of a break, laying of knives for opening of ampoules is excluded.

Storage conditions

In original packing at a temperature not higher than 25 Pages.

Not to freeze

to Store out of children’s reach!

Not to use a period of storage of 5 years after expiry date

Prescription status

According to the prescription

CIAO Producer Pharmaceutical

Darnitsa Ukraine, 02093, Kiev, Borispolskaya St., 13.

The name and the country of the owner of the registration certificate

CIAO Pharmaceutical Darnitsa, Ukraine

the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products –
the phone number / fax: (+ 380 44) 207 73 27
e-mail: vigilance@darnitsa.kiev.ua
http://www.darnitsa.ua

Additional information