Antiseptic and Anti-Inflammatory / Obstetrics and Gynecology

Klindabioks 3’s 100mg Vaginal suppository

Brands: Farmaprim (Moldova)

$31.40

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Klindabioks 3's 100mg Vaginal suppository quantity

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Brands:: Farmaprim (Moldova)

Description

The instruction for medical use of KLINDABIOKS medicine the Trade name of Klindabioks the International unlicensed name Clindamycin Dosage Form Suppositories vaginal Structure One suppository contains active agent: clindamycin (in the form of phosphate clindamycin) 100 mg, excipients: solid fat. Description Suppositories of a tsilindrokonichesky form, color, white or white with a yellowish shade. Pharmacotherapeutic group of Antiseptics and antimicrobial drugs for treatment of gynecologic diseases. Antibacterial drugs. Clindamycin. The ATX G01AA10 code the Pharmacological Pharmacokinetics At properties intravaginalny introduction system absorption is about 5%. Well passes placental and histologic barriers, easily gets into biological liquids and fabrics, passes through GEB badly (at inflammation of a meninx the permeability of GEB increases). High concentrations of clindamycin are defined in bile. Clindamycin collects in leukocytes and macrophages. It is found in bodies of a fruit. Cosecretes with maternal milk. It is intensively metabolized in a liver, with education active (N-dimetilklindamitsin and klindamitsinsulfoksid) and inactive metabolites. Elimination half-life makes 1.5-3.5 h, increases at patients with a serious illness of kidneys. About 10% of a dose are removed with urine and about 4% with a stake. Slow excretion, within 7 days. Is not removed from blood by dialysis. The pharmacodynamics Klindamitsin belongs to antibiotics of group of linkozamid. Contacts 50S a subunit of a ribosomalny membrane and inhibits protein synthesis in microorganisms. In therapeutic doses has bacteriostatic action, in high doses has bactericidal effect on sensitive strains. It is active concerning the majority of aerobic gram-positive bacteria (Staphylococcus aureus, S.epidermidis which is producing and not producing penicillinase, Streptococcus spp. (except for S. faecalis) Bacillus anthracis, Corynebacterium diphtheriae, Pneumococci), anaerobic gram-negative bacteria (Bacteroides spp., including the B.fragilis and B.melaninogenicus, Fusobacterium spp groups. (except for F. varium), Veillonella), anaerobic gram-positive asporous bacteria (Propionibacterium, Eubacterium), anaerobic and mikroaerofilny gram-positive cocci (Peptococcus spp., Peptostreptococcus spp.). Some strains of Actinomyces spp are sensitive to clindamycin. and Nocardia asteroides. Clindamycin is also active concerning Chlamydia trachomatis, the majority of strains of Clostridium perfringens and Clostridium tetani. Trichomonas vaginalis, Candida albicans are resistant to drug. It was proved that between clindamycin and lincomycin there is a cross resistance. Presence of antagonism between clindamycin and in vitro erythromycin was shown. The clinical importance of this interaction is unknown. Indications the Bacterial vaginosis caused by microorganisms, sensitive to drug. Route of administration and Intravaginalno’s doses. Suppositories exempt from planimetric packing, previously having cut a film on a suppository contour, enter whenever possible, is deep in a vagina, in a prone position. On one suppository of 1 times a day, just before a dream within 3-7 days in a row. Side effects – a cervicitis, vaginal candidiasis, a vulvovaginitis, a vaginitis / vaginal infections, allergic reactions Seldom – a headache, dizziness, a food faddism – a hyperthyroidism – an abdominal pain, spasms in a stomach, diarrhea, nausea, vomiting, a constipation, dyspepsia, a digestive disturbance, a meteorism, gastrointestinal disturbances – deviations in microbiological tests – irritation of a mucous membrane of a vulva and vagina, disturbance of a menstrual cycle, pain in the field of a basin, uterine bleeding, discharges from a vagina, endometriosis – a dysuria, a glucosuria, a proteinuria – a skin itching, rash, makulopapulezny rash, an erythema, an itching in the injection site, a small tortoiseshell of the Contraindication – hypersensitivity to clindamycin, lincomycin or other components of drug – a myasthenia – the colitis associated with reception of antibiotics in the anamnesis – the profound abnormal liver functions and kidneys – pregnancy (I trimester), the lactation period Medicinal interactions Strengthens effect of drugs of rifampicin, aminoglycosides – streptomycin, gentamycin, deepens the muscle relaxation caused by N-holinoblokatorami. It is incompatible with erythromycin, ampicillin, diphenylhydantoin, barbiturates, Aminophyllinum, calcium a gluconate and magnesium sulfate. Intravaginalny use of Klindabioks can lead special instructions to the strengthened growth of insensitive microorganisms, especially yeast-like mushrooms. Use of Klindabioks, as well as other antibacterial agents, can cause diarrhea, and in certain cases – pseudomembranous colitis, which can be both moderate, and zhizneugrozhayushchy. In this regard at emergence against the background of therapy of the profound or long diarrhea it is necessary to cancel drug and if necessary to carry out diagnostic and treatment. The patient has to be informed that during use of Klindabioks, vaginal suppositories it is necessary to avoid sexual contacts and also use of other types of the products intended for intravaginalny introduction (for example, tampons, syringings). Klindabioks in the form of vaginal suppositories contains components which can reduce durability of products from latex or rubber (condoms, contraceptive vaginal diaphragms). Therefore use of similar products during drug treatment Klindabioks in the form of vaginal suppositories is not recommended. Use for children Safety and efficiency of drug at patients of children’s age is not established. Pregnancy and feeding by a breast of Klindabioks gets through a placenta into the blood system of a fruit. It is allocated with breast milk. Intravaginalny use of the drug Klindabioks in II and III trimesters of pregnancy is possible only when the expected advantage for mother exceeds potential risk for a fruit. Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms Drug does not affect the speed of response of drivers of the vehicles and persons serving the installations requiring special attention. The overdose Due to the low absorption of drug overdose is improbable. A form of release and packing On 3 suppositories in blister strip packaging from a film polyvinylchloride laminated by polyethylene. On 1 blister strip packaging together with the instruction for medical use in the state and Russian languages put in a pack from cardboard. To Store storage conditions in the dry, protected from light place, at a temperature not over 25 s. Not to freeze. To store out of children’s reach! 3 years not to apply a period of storage after an expiration date. Prescription status According to the prescription the Producer of Ltd company to PHARMAPRY st. Krinilor, 5, page. Porumben, the area Kriulen, the Republic of Moldova, MD-4829 the Owner of the registration certificate of Ltd company PHARMAPRIM, the Republic of Moldova the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products (goods) and responsible for post-registration observation of safety medicinal a sredstvapredstavitelstvo of PHARMAPRIM SRL in Republic of Kazakhstan, Almaty, Gogol St., 86, office 528

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