FREE Shippingto US, AU, UK and EU on all orders over $149
/

Hofitol (Chophytol, Artichoke) 60 coated tablets

$20.20

7193c1ed0a2c

Description

The instruction for medical use

of Hofitol Torgovoye medicine a name
Hofitol

Mezhdunarodnoye the unlicensed name
Is not present

the Dosage form
of the Tablet, coated

Structure
One tablet contains
active agent – an artichoke (extract of leaves dry, water) 200.0 mg
excipients: magnesium trisilicate, starch corn prezhelatinizirovanny, talc, magnesium stearate, gummilak (shellac), rosin, gelatin, sucrose, calcium carbonate, dye disperse, karnaubsky wax,
polysorbate 80.
(composition of dye disperse: sucrose, ferrous oxides yellow, black and brown (E 172), methylparahydroxybenzoate (E 218), ethylparahydroxybenzoate (E 214)).

Description
Round tablets of a biconvex form, coated brown color.

The pharmacotherapeutic
Drug group for treatment of diseases of a liver and biliary tract. Other drugs for treatment of diseases of biliary tract.
The ATX A05AX code

the Pharmacological

Pharmacokinetics Because properties extract of an artichoke contains a complex of biologically active agents among which: polyphenolic substances (lyuteolin, Cinorinum, caffeine, chlorogenic and ferulic acids), bioflavonoids, inulin, minerals and microelements, vitamins, seskviterpenlaktona, and effect of drug is caused by cumulative action of all its components, carrying out kinetic researches is not possible, all components cannot be tracked by means of markers or bioresearches. For the same reason it is impossible to find all metabolites of drug.

A pharmacodynamics
the Pharmacological effect of drug is caused by a complex of biologically active agents which are a part of a field artichoke.
Pharmakodinamichesky researches indicate bile-expelling, hepatoprotective, antioxidant, soft diuretic, gipokholesterinemichesky effects.
Combined effect of polyphenolic substances, such as lyuteolin, Cinorinum, caffeine, chlorogenic and ferulic acids, interferes with biosynthesis of cholesterol due to specific blocking of activation of hydroksimetilglutaril-KoA-reduktazy insulin, without influencing other insulin-dependent phenomena (such as synthesis of lactic acid).
Caffeine acid reduces the level of the aflatoxin synthesized by pathogenic fungal flora.
The chlorogenic acid which is to derivatives of caffeine acid slows down release of glucose in blood after meal and inhibits glucose-6-phosphatase, reducing a hepatic glycogenolysis.
The ferulic acid representing a metilirovanny form of caffeine acid and being a lignocellulose component connects lignin with polysaccharides. Derivatives of ferulic acid skolimozid and skopoletin normalize arterial blood pressure, possess anti-inflammatory action, increase serotonin level – the main endogenous antidepressant.
Cinorinum, cyanidine, tsianopikrin are more difficult derivatives of caffeine acid, possess antioksidanty, bile-expelling, spasmolytic, hepatoprotective action, increase bile evacuation, reduce cholesterol level.
Bioflavonoids lyuteolin, apigenin, hesperidin, meletin and Rutinum are antioxidants with anti-inflammatory action.
Lyuteolin and apigenin promote metabolism of carbohydrates, are interfered production and secretion of anti-inflammatory cytokines the FNO-alpha and SILT-1 interleukins by a beta, IL-6, IL-4, IL-13.
Apigenin blocks forming of uric acid.
Hesperidin reduces the content of the general cholesterol, arterial blood pressure. Meletin slows down synthesis and secretion of a histamine, inhibits enzyme a lipoxygenase and CYP3A4 cytochrome.
Minerals and microelements which are contained in an artichoke: calcium, potassium, magnesium, iron, ascorbic acid and also carotene, B1 and B2 vitamins, inulin contribute to normalization of exchange processes.
High content of potassium in relation to sodium positively affects salt metabolism.
Inulin stimulates the immune system, increases absorption of minerals (in particular calcium), reduces risk of atherosclerosis and modulates levels of hormones of carbohydrate metabolism – insulin and a glucagon. The mechanism of action is caused by impact of products of metabolism of inulin on cellular proteins. Lowering of the level of triglycerides in blood and a liver comes through reduction of secretion of a lipoprotein of very low density from a liver as a result of decrease of the activity of lipogenous enzymes. The activity of these enzymes decreases through direct inhibition inulin metabolites.
Seskviterpenlaktona improve glomerular filtrational ability of kidneys, have soft kaliysberegayushchy diuretic effect, strengthen a diuresis and discharge of the final products of nitrogen metabolism and products of a hepatic detoxication.

Indications
as a part of complex therapy
– dyskinesia of biliary tract on hypokinetic type
– chronic not calculous cholecystitis
– chronic hepatitis
– chronic nephrite.

Route of administration and doses
Inside.
To adults and children 12 years on 2-3 tablets 3 times a day to food are more senior.
Children are from 6 to 12 years old on 1 tablet 3 times a day to food.
Duration of a course of treatment is 2-3 weeks.

Side effects
– allergic reactions (skin rash, an itching)
At prolonged use in high doses
– diarrhea
– an abdominal pain.

Contraindications
– hypersensitivity to drug components
– cholelithiasis
– mechanical jaundice
– acute diseases of a liver, kidneys, zhelche- and urinary tract
– a chronic liver failure
– children’s age up to 6 years.

Medicinal interactions
are not revealed

the Special
instructions Pregnancy and the period of a lactation
Use of drug at pregnancy is possible in case the expected advantage for mother exceeds potential risk for a fruit.
Use in the period of a lactation is authorized.
Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms

the Overdose
Symptoms does not influence: diarrhea, abdominal pain.
Treatment: drug withdrawal, symptomatic therapy.

A form of release and packing
On 30 tablets in blister strip packaging from a film of PVC or a film of PVH/PVDH/PE and aluminum foil.
On 2 planimetric packs together with the instruction for medical use in the state and Russian languages place in a pack from cardboard.
On 30 tablets in blister strip packaging from a film of PVC or a film of PVH/PVDH/PE and aluminum foil.
On 6 planimetric packs together with the instruction for medical use in the state and Russian languages place in a pack from cardboard.

Storage conditions
At a temperature not higher than 25 of 0C.
To store out of children’s reach!

3 years
not to apply a period of storage after the expiration date specified on packing.

Prescription status
Without prescription

Laboratories Roza-Fitopharma Producer,
France 68 Rue Jean-Jacques Rousseau 75001 Paris, France

the Owner of the registration certificate
Laboratories Roza-Fitopharma,
France 68 Rue Jean-Jacques Rousseau 75001 Paris, France

the Address of the organization accepting in the territory of the Republic of Kazakhstan claims from consumers on quality of products
Representative office of FIC MEDICAL LLP (FICK MJEDIKAL) in Republic of Kazakhstan, Tolya St. bi 69, office 33, 050000, Almaty, Kazakhstan
ph.: +7 (727) 272 93 08, fax: +7 (727) 272 90 25
e-mail: fic_kz@ficmedical.kz

the Head of department R.S. Kuzdenbayeva
of pharmacological examination

Deputy head of department
of pharmacological examination Mirmanova R.K.

Expert

the CEO
of Representative office of FIC MEDICAL LLP
(FICK MJEDIKAL) in RK F.R. Aliyev.

Additional information

Ingredient

Reviews

There are no reviews yet.

Be the first to review “Hofitol (Chophytol, Artichoke) 60 coated tablets”

Your email address will not be published. Required fields are marked *