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GALAVIT® 100 mg, 10 suppositories

$50.00

308edb505186

Description

One suppository contains

  • Active ingredient – sodium aminodihydrophthalazinedione (Galavit®) 100 mg,
  • excipients: witepsol W-35 (fatty acid glycerides, witepsol H-15 (fatty acid glycerides)

 

Pharmacological properties

Pharmacokinetics

Galavit® is quickly absorbed, penetrates into organs, tissues and biological fluids. The maximum plasma concentration after rectal administration is reached after 23 minutes. Communication with plasma proteins – 6%. The maximum concentration of the drug is in the kidneys, the minimum in the muscles and brain tissues. The absolute bioavailability of Galavit® with rectal administration is 61%. The drug penetrates the blood-brain and placental barrier. It is excreted from the body mainly through the kidneys. After rectal administration, the half-life of the drug is 40-60 minutes.

Pharmacodynamics

Galavit® is used as an immunomodulatory and anti-inflammatory agent in the complex therapy of immunodeficiency states. The mechanism of action of the drug is associated with its ability to affect the functional and metabolic activity of phagocytic cells (monocytes / macrophages, neutrophils, natural killers). In addition, Galavit® normalizes antibody formation, indirectly stimulates the production of endogenous interferons (IFN-α, IFN-γ).

In inflammatory diseases, the drug reversibly inhibits for 6-8 hours the excessive synthesis of hyperactivated macrophages of tumor necrosis factor-α, interleukin-1, interleukin-6 and other pro-inflammatory cytokines, reactive oxygen species, the level of which determines the degree of inflammatory reactions, their cyclicity, as well as the severity intoxication and the level of oxidative stress. Normalization of the functional state of macrophages leads to the restoration of the antigen presenting and regulatory functions of macrophages, and a decrease in the level of autoaggression. Stimulates the bactericidal activity of neutrophilic granulocytes, enhancing phagocytosis and increasing the body’s nonspecific resistance to infectious diseases. The main pharmacological effects (immunomodulatory and anti-inflammatory) are observed within 72 hours.

 

What Are the Indications for Galavit Use?

As an immunomodulating and anti-inflammatory agent in the complex therapy of immunodeficiency conditions in adults and adolescents over 12 years of age:

  • infectious and inflammatory urogenital diseases (urethritis of chlamydial and trichomonas etiology, chlamydial prostatitis, acute and chronic salpingo-oophoritis, endometritis);
  • purulent-inflammatory diseases of the pelvic organs;
  • chronic recurrent diseases caused by the herpes virus;
  • diseases caused by the papilloma virus;
  • postoperative rehabilitation of patients with uterine myoma;
  • complications of the postoperative period in women of reproductive age;
  • postoperative purulent-septic complications and their prevention (including in cancer patients);
  • chronic recurrent furunculosis, erysipelas;
  • nonspecific prevention and treatment of influenza and acute respiratory infections.
  • inflammatory diseases of the mucous membrane of the mouth and throat, periodontal disease;
  • viral hepatitis;
  • infectious intestinal diseases accompanied by intoxication and / or diarrhea;
  • peptic ulcer of the stomach and duodenum;
  • asthenic conditions, neurotic and somatoform disorders, decreased physical performance (including in athletes); mental, behavioral and post-withdrawal disorders in alcohol and drug addiction;

 

How Should You Use Galavit?

  • Method of Administration: Galavit should be used rectally. To use it, first remove the suppository from its packaging. Then, insert the suppository into the rectum. It’s recommended to empty your bowels beforehand for better absorption of the medication.

What Are the Dosage Instructions?

  • Dosage and Duration Depend on the Disease:
    • The dose and duration of Galavit treatment depend on the nature, severity, and duration of the illness.

 

  • For Urogenital Diseases:
    • For chlamydial and trichomonas urethritis, chlamydial prostatitis:
      • Day 1: 1 suppository twice.
      • Then: 1 suppository every other day.
      • Course: 10-15 suppositories, depending on severity.

 

  • For Salpingo-oophoritis, Acute Endometritis:
    • Acute phase:
      • 2 days: 2 suppositories once daily.
      • Then: 1 suppository every 72 hours.
    • Chronic phase:
      • 5 days: 1 suppository daily.
      • Then: 1 suppository every 72 hours.
      • Course: 20 suppositories.

 

  • For Acute and Chronic Purulent Diseases of the Pelvis:
    • Acute phase:
      • Day 1: 2 suppositories once.
      • Next 3 days: 1 suppository daily.
      • Then: 1 suppository every other day for 5 days.
      • Course: 10 suppositories.
    • Chronic phase: Same as acute, but course is 20 suppositories.

 

  • For Chronic Recurrent Diseases Caused by Herpes Virus:
    • 5 days: 1 suppository daily.
    • Then: 1 suppository every other day.
    • Course: 15 suppositories.

 

  • For Diseases Caused by Papilloma Virus:
    • 5 days: 1 suppository daily.
    • Then: 1 suppository every other day.
    • Course: 20 suppositories.

 

  • For Postoperative Rehabilitation in Uterine Fibroids and Complications:
    • 5 days: 1 suppository daily.
    • Then: 1 suppository every other day.
    • Course: 15 suppositories.

 

  • For Prevention and Treatment of Surgical Complications:
    • Pre- and Post-operation (including in cancer patients):
      • 5 days: 1 suppository daily before surgery.
      • After surgery: 1 suppository every other day and then every 72 hours.
      • Course: 20 suppositories.
      • In severe cases: Start with 2 suppositories once or twice daily.

 

  • For Chronic Recurring Furunculosis, Erysipelas:
    • 5 days: 1 suppository daily.
    • Then: 1 suppository every other day.
    • Course: 20 suppositories.

 

  • For Non-specific Prevention and Treatment of Flu and Acute Respiratory Infections:
    • 1 suppository daily for 5 days.

 

  • For Inflammatory Diseases of the Oral Mucosa and Throat, Periodontal Diseases:
    • Initial dose: 1 suppository daily for 5 days.
    • Then: 1 suppository every 72 hours.
    • Course: 15 suppositories.

 

  • For Viral Hepatitis:
    • Initial dose: 2 suppositories once.
    • Then: 1 suppository twice daily until symptoms subside.
    • Continue with 1 suppository every 72 hours.
    • Course: 20-25 suppositories.

 

  • For Acute Infectious Intestinal Diseases with Diarrhea:
    • Initial dose: 2 suppositories once.
    • Then: 1 suppository twice daily until symptoms subside.
    • Continue with 1 suppository every 72 hours.
    • Course: 20-25 suppositories.

 

  • For Gastric and Duodenal Ulcers in Acute Phase:
    • 2 days: 2 suppositories once daily.
    • Then: 1 suppository every 72 hours.
    • Course: 15-25 suppositories.
    • Chronic phase: Same as acute, but course is 20 suppositories.

 

  • For Asthenic Conditions, Neurotic and Somatoform Disorders, Post-abstinence Disorders in Patients with Alcohol and Drug Dependence:
    • 5 days: 1 suppository daily.
    • Then: 1 suppository every 72 hours.
    • Course: 15-20 suppositories.

 

  • For Enhancing Physical Performance:
    • 1 suppository every other day for 5 suppositories.
    • Then: 1 suppository every 72 hours, up to 20 suppositories in total.

 

  • Important Note:
    • If there is no improvement after treatment, or if symptoms worsen or new symptoms appear, consult a doctor immediately.
    • Use Galavit only according to the indications, method of use, and doses specified in the instructions.

 

Side effects

Rarely (from 0.01% to 0.1%)

– allergic reactions from the skin and subcutaneous tissues: skin rash, itching, urticaria

 

Contraindications

– individual sensitivity to the drug

– pregnancy and lactation

– children’s age up to 12 years

 

Drug Interactions

With simultaneous use, it is possible to reduce the course doses of antibiotics. Cases of incompatibility with other drugs have not been noted.

 

Special instructions

Application in pediatrics

The drug is not prescribed to children under 12 years of age.

Pregnancy and lactation

The drug is not prescribed to pregnant women, women during breastfeeding

Features of the effect of the drug on the ability to drive a vehicle and potentially dangerous mechanisms

Does not affect.

 

Overdose

There are no data on cases of overdose of Galavit®.

 

Storage conditions

Store in a dry, dark place at a temperature not exceeding 25°C.
Keep out of the reach of children!
Shelf life – 3 years
Do not use after the expiration date.

Additional information

Ingredient

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