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Dolar 20g of gel for topical application

$4.00

396aaafaa437

Description

Trade name
Dolaren

Mezhdunarodnoye the unlicensed name
Is not present

the Dosage form
Gel for external use

Structure
20 grams of gel contain
active agents: diclofenac of diethyl amine of sodium equivalent to diclofenac – 0.227 mg, menthol – 1.047 mg, methyl salicylate – 2.057 mg
excipients: linseed oil, karbopol-940, diethyl amine, propylene glycol, alcohol benzylic, disodium EDTA, sodium methylparaben, hydroxytoluene, hydroksipropilmetit the cellulose, water purified.

The description
Soft gel of white color

Pharmacotherapeutic group
Non-steroidal anti-inflammatory drugs for topical administration. Other
drugs Code of Automatic Telephone Exchange: M02AX10

the Pharmacological

Pharmacokinetics Gel properties for topical administration, is absorbed through an integument, deeply getting into hypodermic fatty tissue, muscle tissue, the articulate capsule and synovial fluid by direct diffusion and provides analgesic effect. Effect of drug steps in a few minutes after putting gel on skin and reaches a maximum during 20–30 At long treatment or when drawing on extensive sites of defeat diclofenac gets into blood plasma.
Concentration in synovial fluid rather stable, and in blood plasma quickly decrease. Diclofenac in a liver, by conjugation with glucuronic acid is metabolized.

Dolaren’s pharmacodynamics – non-steroidal anti-inflammatory drug (NPVS). Strengthens a blood stream and activates a metabolism in the subject fabrics, has the analgeziruyushchy, warming and anti-inflammatory effect.
Inhibits type (COG) 1 and 2 cyclooxygenase, breaks metabolism of arachidonic acid that leads to decrease in synthesis of prostaglandins. Reduces constraint and a swelling of joints, has anti-inflammatory effect.
Methyl salicylate have the local irritating and distracting effect caused by influence on sensitive nerve terminations and vasodilatation of the subject fabrics.
Menthol at topical administration has vasodilating and analgesic effect, gives feeling of a cool.
At topical administration of gel the system influence of its components is minimum.

Indications
– a miositis
– a fibrositis
– a muscle strain and sinews, a musculoskeletal system injury
– muscle and joints pain at heavy physical activities
– rheumatic diseases (the bursitis, arthritis, tendosinovit, a tendinitis).

The route of administration and doses
apply Gel a thin layer to skin of an affected area 3–4 times a day on 2–4 g and slightly rub before full absorption. The average daily dose makes 10 g. Reduction of expressiveness or disappearance of the main clinical symptoms is noted usually in the first days from the beginning of therapy.
The course of treatment should not exceed 10 days without consultation of the doctor.
Not to apply on the damaged sites of skin

Side effects
Seldom
– erubescence
– an itching, burning
– xeroderma
– a small tortoiseshell
In isolated cases
– generalized rash
– a Quincke’s disease
– suffocation
– a fotosensebilization (when putting drug on extensive sites of skin)

Contraindications
– hypersensitivity to drug components
– bronchial asthma
– a round ulcer of a stomach and/or duodenum in an aggravation phase
– the period of pregnancy and a lactation
– children’s age up to 12 years.

Medicinal interactions
of Dolaren can be applied along with oral administration of tablets of diclofenac of sodium.
At prolonged use and/or on the extensive site, drug can strengthen effect of anticoagulants, corticosteroids, lithium drugs, to increase concentration of digoxin in blood. Dolaren weakens effect of furosemide and thiazide diuretics and also reduces tolerance of other non-steroidal anti-inflammatory drugs, strengthening their damaging action on a mucous membrane of digestive tract.

The special
instructions Gel it is intended only for external use, it is impossible to apply drug to the injured skin. It is necessary to avoid hit of gel on open wounds, mucous membranes of a nose and eyes.
It is necessary to be careful at Dalaren’s appointment to patients at whom the hypersensitivity to non-steroidal anti-inflammatory drugs was observed earlier, there is in the anamnesis a peptic ulcer of a stomach and duodenum, disturbance of blood circulation, an abnormal liver function or kidneys.
The feature of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms
does not influence.

Overdose
Considering this dosage form does not possess systemic action, the overdose is improbable.

A form of release and packing
Gel for external use.
On 20 g in plastic tubas together with the instruction for use in the Russian and Kazakh languages in a cardboard box.

Storage conditions
In the dry, protected from light place, at a temperature not above 25 °C. To store out of children’s reach!

2 years
not to apply a period of storage after an expiration date.

Prescription status
Without prescription

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