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Arbidol 100 mg, 20 capsules


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The instruction for medical use of ARBIDOL® medicine the Trade name of Arbidol® the International unlicensed name Umifenovir Lekarstvennaya a form of the Capsule of 100 mg Structure One capsule contains  active agent umifenovir (an umifenovira of a hydrochloride monohydrate in terms of an umifenovir a hydrochloride) 100 mg, excipients: potato starch, cellulose microcrystalline, silicon dioxide colloidal (aerosil), povidone (kollidon 25), calcium stearate, structure of a cover of the capsule: titan dioxide (E 171), dye quinolinic yellow (E 104), dye sunset yellow (E 110), acetic acid, gelatin. Description of Capsule No. 1 of white color, lid of yellow color. Contents of capsules – the mix containing granules and powder from white or white with chartreuse till the color, light yellow or light yellow with a greenish shade. Pharmacotherapeutic group Antiviral drugs of systemic action. Antiviral drugs other. The ATX J05AX code the Pharmacological Umifenovir Pharmacokinetics properties is quickly absorbed and distributed on bodies and fabrics. The maximum concentration in blood plasma at reception in a dose of 100 mg is reached in 1.5 h. It is metabolized in a liver. Elimination half-life is equal 17-21 h. About 40% are removed in not changed look, generally with bile (38.9%) and in insignificant quantity kidneys (0.12%). Within the first day 90% of the entered dose are removed. Pharmacodynamics of Arbidol® of  antiviral broad-spectrum agent. Specifically suppresses influenza viruses And yes In, the coronavirus associated with the heavy sharp respiratory syndrome (HSRS). On the mechanism of antiviral action treats fusion inhibitors (fusion), interacts with hemagglutinin of a virus and interferes with merge of a lipidic viral envelope and cellular membranes. Has moderate immunomodulatory effect, increases resistance of an organism to viral infections. Interferon – the inducing activity possesses – in a research on mice the induction of interferon was noted in 16 hours, and high credits of interferon remained in blood till 48 o’clock after introduction. Stimulates cellular and humoral reactions of immunity: raises number of lymphocytes in blood, in particular T-cells (CD3), raises number T-helperov (CD4), without influencing the level of T-suppressors (CD8), normalizes the immunoregulatory index, stimulates phagocytal function of macrophages and raises number of natural killers (NK cells). Increases resistance of an organism to viral infections. The therapeutic effectiveness in viral infections is shown in reduction of duration and weight of the course of the disease and its main symptoms and also in decrease in frequency of development of the complications connected with a viral infection and exacerbations of chronic bacterial diseases. Treats low-toxic drugs (LD50&gt, 4 g/kg). Does not make any negative impact on a human body at oral administration in the recommended doses. Indications Prevention and treatment at adults: – flu A and B, other SARS, the heavy sharp respiratory syndrome (HSRS) (including complicated by bronchitis, pneumonia), – secondary immunodeficiency, Complex therapy of chronic bronchitis, pneumonia and recurrent herpes infection. Prevention of postoperative infectious complications. A route of administration and doses Inside, before meal. For nonspecific prevention and treatment of flu and other SARS at adults: Nonspecific prevention: For nonspecific prevention in the period of a flu epidemic and other SARS: 200 mg two times a week within 3 weeks. At direct contact with patients with flu and other SARS: 200 mg once a day within 10-14 days. Treatment of flu and other SARS: – at an uncomplicated course: 200 mg 4 times a day (each 6 hours) within 5 days. – at development of complications (bronchitis, pneumonia, etc.): adult – 200 mg 4 times a day (each 6 hours) within 5 days, then a single dose once a week within 4 weeks. For nonspecific prevention and treatment of the heavy sharp respiratory syndrome (HSRS): For nonspecific prevention of HSRS (at contact with the patient): on 200 mg once a day. For treatment of HSRS: 200 mg 2 times a day within 8-10 days. In complex therapy of chronic bronchitis, herpes infection: 200 mg 4 times a day (each 6 hours) within 5-7 days, then a single dose 2 times a week within 4 weeks. Prevention of postoperative complications: 200 mg in 2 days prior to operation, then for the 2 and 5 day after operation. A single dose – 200 mg. The maximum daily dose – 800 mg. Side effects Seldom (with a frequency from 1/10 000 to 1/1000) allergic reactions: skin rash, naggers Protivopokazaniya hypersensitivity to drug components children’s and teenage age up to 18 years pregnancy and the period of a lactation Medicinal interactions When assigning with other medicines of negative effects were not marked out. It is necessary to appoint the special instructions Arbidol® with care the patient with associated diseases of a cardiovascular system, a liver and kidneys. Does not show the central neurotropic activity and it can be applied in medical practice in the preventive purposes at almost healthy faces of various professions including requiring special attention and coordination of movements (drivers of transport, operators, etc.). Features of influence of medicine on ability to run the vehicle or potentially dangerous mechanisms Use of drug in therapeutic doses at the persons working with mechanisms and drivers of motor transport not contraindicated. Overdose Symptoms – cases of overdose are noted. Treatment – symptomatic (in case of overdose emergence). A form of release and packing On 10 capsules in blister strip packaging from a film of the polyvinylchloride and printing aluminum foil varnished. 1, 2 or 4 planimetric packs with the instruction for medical use in the state and Russian languages in a pack from cardboard. To Store storage conditions at a temperature not above 25 °C. To store out of children’s reach! 2 years After the termination of an expiration date drug not to use a period of storage! Prescription status Without prescription JSC Pharmstandard-Leksredstva Producer

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